WARNING

Northera is a medication that contains the active ingredient droxidopa. It is primarily used to treat neurogenic orthostatic hypotension (NOH), a condition characterized by low blood pressure upon standing up. While Northera can be effective in managing NOH, it is important to be aware of the potential risks associated with its use. Here are some of the notable risks:

• Supine Hypertension: Northera can cause a significant increase in blood pressure when a person is lying down. Monitoring blood pressure regularly is essential to avoid complications associated with high blood pressure.
• Headache: Headaches are a commonly reported side effect of Northera. While they are usually mild to moderate in intensity, they can be bothersome for some individuals.
• Cardiovascular Effects: Northera may lead to an increase in heart rate and palpitations. Patients with underlying cardiovascular conditions should use Northera with caution and under the guidance of a healthcare professional.
• Hypersensitivity Reactions: Some individuals may experience allergic reactions to Northera, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.
• Gastrointestinal Issues: Northera can cause nausea, vomiting, and abdominal pain. Taking the medication with food may help alleviate these symptoms.
• Dizziness and Falls: Northera can cause dizziness or lightheadedness, which may increase the risk of falls, especially in elderly patients or those with balance problems. It is important to be cautious when standing up and to move slowly.
• Drug Interactions: Northera may interact with other medications, including those that affect blood pressure or heart rate. Inform your healthcare provider about all the medications you are taking to avoid potential interactions.

It is crucial to consult with a healthcare professional before starting Northera or making any changes to your medication regimen. They can provide personalized advice, evaluate the potential risks and benefits, and monitor your response to the medication.

Why is this medication prescribed?

Northera (droxidopa) is prescribed primarily for the treatment of neurogenic orthostatic hypotension (NOH). NOH is a condition characterized by a significant drop in blood pressure upon standing up, resulting in symptoms like dizziness, lightheadedness, fainting, and an overall decrease in quality of life. Northera works by increasing norepinephrine levels in the nervous system, which helps to raise blood pressure and alleviate the symptoms of NOH.

How should this medicine be used?

When using Northera, it is important to follow the instructions provided by your healthcare professional. Here are some general guidelines for its use:

• Dosage: The dosage of Northera varies depending on individual needs and response. Your healthcare provider will determine the appropriate dose for you. It is typically taken orally three times a day, with the first dose taken upon waking up in the morning.
• Timing: Northera should be taken at least three hours before bedtime to avoid difficulties falling asleep.
• Food: Northera can be taken with or without food. However, if you experience gastrointestinal issues, taking it with food may help alleviate these symptoms.
• Compliance: Take Northera as prescribed by your doctor. Do not exceed the recommended dose or change the dosing schedule without consulting your healthcare provider.
• Monitoring: Regularly monitor your blood pressure to ensure that it remains within a safe range. Your doctor may adjust the dosage based on your response and blood pressure readings.
• Other Medications: Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, as Northera may interact with certain medications. Your doctor will determine if any adjustments or precautions are necessary.

It is essential to have regular check-ups with your healthcare provider while taking Northera to monitor your condition and evaluate the effectiveness and safety of the medication. If you have any questions or concerns about the use of Northera, consult your doctor for personalized guidance.

Other uses for this medicine

Northera (droxidopa) is primarily prescribed for the treatment of neurogenic orthostatic hypotension (NOH). However, there may be other off-label uses for Northera as determined by healthcare professionals. Off-label use refers to the use of a medication for a condition or purpose not specifically approved by regulatory authorities. It is important to note that off-label use should only be done under the guidance of a healthcare provider who can assess the potential risks and benefits for the individual patient.

What special precautions should I follow?

Regarding special precautions for Northera, the following factors should be considered:

• Supine Hypertension: Northera can cause a significant increase in blood pressure when a person is lying down. Patients should be closely monitored for supine hypertension and blood pressure should be regularly checked. Adjustments to other medications may be required to manage blood pressure effectively.
• Cardiovascular Conditions: Northera may affect heart rate and blood pressure. Patients with underlying cardiovascular conditions such as arrhythmias, ischemic heart disease, or congestive heart failure should use Northera with caution and under the supervision of a healthcare professional.
• Hypersensitivity: Individuals who have had a previous hypersensitivity reaction to Northera or any of its components should not use the medication.
• Renal Impairment: Northera should be used with caution in patients with renal impairment. Dose adjustments may be necessary, and close monitoring of renal function is recommended.
• Pregnancy and Breastfeeding: The safety of Northera in pregnant or breastfeeding women has not been established. Consult a healthcare professional to assess the risks and benefits before using Northera in these situations.
• Other Medications: Northera may interact with other medications, including those that affect blood pressure, heart rate, or monoamine oxidase inhibitors (MAOIs). Inform your healthcare provider about all the medications you are taking to avoid potential interactions.

It is important to discuss your medical history, current medications, and any concerns with your healthcare provider before starting Northera. They can provide personalized advice, assess the potential risks and benefits, and guide you on the appropriate use of Northera based on your specific circumstances.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Northera (droxidopa). However, taking it with food may help alleviate gastrointestinal issues that some individuals may experience as a side effect. If you have any concerns or questions about your diet while taking Northera, it is recommended to consult with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Northera, it is generally advised to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. Taking Northera as prescribed by your healthcare provider is important for maintaining its effectiveness. If you have any concerns or questions about missed doses, it is recommended to contact your healthcare provider for guidance.

What side effects can this medication cause?

Northera (droxidopa) can cause several side effects. It’s important to note that not everyone experiences these side effects, and their severity can vary from person to person. Common side effects of Northera may include:

• Headache: Headaches are a frequently reported side effect of Northera. They are typically mild to moderate in intensity.
• Dizziness: Northera can cause dizziness or lightheadedness, especially when standing up. It is important to be cautious when changing positions to minimize the risk of falls.
• High Blood Pressure (Supine Hypertension): Northera can cause a significant increase in blood pressure when lying down. Regular monitoring of blood pressure is necessary to manage this effect and prevent complications.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting while taking Northera. Taking the medication with food may help alleviate these symptoms.
• Abdominal Pain: Abdominal pain or discomfort is another possible side effect of Northera. If persistent or severe, it is important to consult a healthcare professional.
• Palpitations: Northera may lead to an increased heart rate and palpitations. If you experience any abnormal heart rhythm or discomfort, seek medical attention.
• Fatigue: Some individuals may experience fatigue or tiredness while taking Northera.
• Insomnia: Difficulty falling asleep or staying asleep may occur in some cases. It is recommended to take Northera at least three hours before bedtime.
• Ankle Swelling: Swelling of the ankles (edema) can be a side effect of Northera. If you notice significant swelling or if it is accompanied by other symptoms, consult your healthcare provider.
• Allergic Reactions: Although rare, allergic reactions to Northera can occur. Signs of an allergic reaction may include rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.

It is important to report any side effects to your healthcare provider, as they can provide guidance and determine the best course of action. They may adjust the dosage or recommend alternative treatments if the side effects are intolerable or severe.

What should I know about storage and disposal of this medication?

Regarding storage and disposal of Northera, it’s crucial to follow the instructions provided by your pharmacist or healthcare provider. Generally, Northera should be stored at room temperature, away from excessive heat, light, and moisture. Keep it in its original container, and make sure to keep it out of reach of children and pets.

When it comes to disposal, it is recommended to follow local regulations or guidelines for medication disposal. If you have any expired or unused Northera, consult your pharmacist or local waste management authority on the appropriate disposal method. They can provide guidance on how to safely dispose of the medication while minimizing environmental impact.

In case of emergency/overdose

• Call Emergency Services: If you or someone else is experiencing a medical emergency or exhibiting severe symptoms, call emergency services immediately.
• Contact Poison Control: If you suspect an overdose or have concerns about the effects of taking too much Northera, contact your local poison control center or a healthcare professional for guidance. They can provide specific instructions based on your situation.

What other information should I know?

• Regular Monitoring: Your healthcare provider may want to regularly monitor your blood pressure, heart rate, and other relevant health parameters while you are taking Northera. Attend scheduled appointments and follow-up visits as recommended.
• Medication Interactions: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and supplements. Some medications can interact with Northera and affect its effectiveness or increase the risk of side effects.
• Allergic Reactions: If you have previously experienced an allergic reaction to Northera or any of its ingredients, inform your healthcare provider. It is important to avoid taking Northera if you have a known allergy to it.
• Special Medical Conditions: Inform your healthcare provider about any pre-existing medical conditions, especially cardiovascular conditions, kidney problems, or a history of hypersensitivity reactions. They will consider these factors when prescribing and monitoring your use of Northera.

Always follow the instructions and advice provided by your healthcare provider regarding the use, storage, and disposal of Northera. If you have any concerns or questions, do not hesitate to consult with your healthcare professional or pharmacist for further clarification and guidance.