Why is this medication prescribed?

Bempedoic acid is a prescription medication used to treat high cholesterol levels in adults. It belongs to a class of drugs called ATP citrate lyase inhibitors. Bempedoic acid works by blocking an enzyme called ATP citrate lyase, which is involved in the production of cholesterol in the liver. By inhibiting this enzyme, bempedoic acid helps lower LDL cholesterol, also known as “bad” cholesterol.

Bempedoic acid is typically prescribed to individuals who have high cholesterol levels and are unable to achieve their target cholesterol levels through diet and exercise alone. It is often used as an adjunct therapy along with a statin medication or as a stand-alone treatment in patients who cannot tolerate statins or have contraindications to their use.

How should this medicine be used?

When using bempedoic acid, it is essential to follow your healthcare provider’s instructions and the medication’s specific guidelines. Typically, the recommended dose is 180 mg (one tablet) taken orally once daily with or without food. The tablet should be swallowed whole and not crushed, chewed, or split. It is important to take the medication regularly and consistently to achieve the best results.

If you have any specific questions or concerns about bempedoic acid or its usage, it is advisable to consult with your healthcare provider or pharmacist, as they can provide you with personalized advice based on your medical history and current condition.

Other uses for this medicine

Bempedoic acid is primarily prescribed for the treatment of high cholesterol levels. However, it is important to note that its approved uses are limited to this indication. Currently, there are no other approved uses for bempedoic acid beyond its cholesterol-lowering effects.

What special precautions should I follow?

Regarding special precautions, it is crucial to consider the following:

• Allergies: Inform your healthcare provider if you have any known allergies or hypersensitivity to bempedoic acid or any of its components. This medication may contain inactive ingredients that could cause allergic reactions or other problems.
• Pregnancy and breastfeeding: The safety of bempedoic acid during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, it is essential to discuss the potential risks and benefits of using bempedoic acid with your healthcare provider.
• Liver function: Bempedoic acid is primarily metabolized in the liver. Individuals with liver impairment or pre-existing liver conditions may require closer monitoring while using this medication. Your healthcare provider may need to adjust the dosage or choose an alternative treatment if you have significant liver function abnormalities.
• Muscle-related side effects: Bempedoic acid, like some other cholesterol-lowering medications, may have the potential to cause muscle-related side effects, including muscle pain, tenderness, or weakness. If you experience unexplained muscle symptoms while taking bempedoic acid, contact your healthcare provider promptly.
• Drug interactions: Bempedoic acid can interact with other medications, including certain cholesterol-lowering drugs, immunosuppressants, antifungals, and antibiotics. Inform your healthcare provider about all the medications, supplements, or herbal products you are currently taking to avoid potential drug interactions.

As with any prescription medication, it is crucial to follow your healthcare provider’s instructions, adhere to the prescribed dosage, and promptly report any unusual or concerning symptoms. Your healthcare provider is the best resource for providing personalized advice and guidance based on your specific medical situation.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with bempedoic acid. However, it is generally recommended to follow a healthy diet and lifestyle to manage high cholesterol levels effectively. This typically involves reducing saturated fats, trans fats, and cholesterol in your diet, increasing your intake of fruits, vegetables, whole grains, and lean proteins, and maintaining a regular exercise routine. It’s important to consult with your healthcare provider or a registered dietitian for personalized dietary recommendations based on your individual needs and medical condition.

What should I do if I forget a dose?

If you happen to forget a dose of bempedoic acid, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It is important to maintain consistent and regular dosing for the medication to be effective. If you have any concerns or questions about missed doses or your dosing schedule, it is advisable to consult your healthcare provider or pharmacist for guidance. They can provide specific instructions based on your situation and help ensure the appropriate use of the medication.

What side effects can this medication cause?

Bempedoic acid, like any medication, can potentially cause side effects. Not everyone who takes bempedoic acid will experience these side effects, and the severity and frequency of side effects may vary among individuals. It is important to discuss potential side effects with your healthcare provider before starting bempedoic acid. Some of the possible side effects of bempedoic acid include:

• Muscle-related side effects: This may include muscle pain, tenderness, weakness, or muscle inflammation (myositis). If you experience any unexplained muscle symptoms, it is essential to contact your healthcare provider, as these may be signs of a rare but serious condition called rhabdomyolysis.
• Gout: Bempedoic acid may increase the risk of gout, a form of arthritis caused by the buildup of uric acid crystals in the joints. If you have a history of gout or are at an increased risk, your healthcare provider may monitor you closely while on bempedoic acid.
• Allergic reactions: Some individuals may experience allergic reactions to bempedoic acid. Seek immediate medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Diarrhea: Diarrhea is a common side effect of bempedoic acid. If it becomes severe or persistent, contact your healthcare provider.
• Nasopharyngitis: This refers to inflammation of the nasal passages and throat, commonly known as a common cold. Symptoms may include a runny or stuffy nose, sore throat, cough, and sneezing.
• Urinary tract infection: Bempedoic acid may slightly increase the risk of urinary tract infections.

It is important to note that this list does not include all possible side effects. If you experience any unexpected or bothersome side effects while taking bempedoic acid, it is crucial to report them to your healthcare provider. They can evaluate your symptoms and provide appropriate guidance.

What should I know about storage and disposal of this medication?

• Storage: Bempedoic acid should be stored at room temperature, away from moisture and heat. Follow the specific storage instructions provided on the medication packaging or by your pharmacist.
• Keep out of reach of children and pets: Ensure that bempedoic acid is stored in a secure location that is out of the reach of children and pets, as they should not have access to prescription medications.
• Disposal: It is important to properly dispose of unused or expired medications to prevent accidental ingestion or misuse. Follow the guidelines provided by your local authorities or healthcare provider for safe medication disposal. Do not dispose of medications in household trash or flush them down the toilet unless instructed to do so.

In case of emergency/overdose

If you believe you have taken too much bempedoic acid or are experiencing severe symptoms, immediately contact your local emergency services or go to the nearest emergency room. Overdose symptoms are not well-documented for bempedoic acid, and the appropriate management will depend on the specific circumstances and severity of the overdose. It is important to seek medical attention promptly for proper evaluation and treatment.

What other information should I know?

• Compliance: It is crucial to take bempedoic acid as prescribed by your healthcare provider. Follow the recommended dosage and frequency of administration to achieve the best results.
• Regular follow-up: Your healthcare provider may periodically monitor your cholesterol levels and overall health to assess the effectiveness and safety of bempedoic acid. Attend all scheduled follow-up appointments and communicate any concerns or changes in your health to your healthcare provider.
• Medication interactions: Inform your healthcare provider about all the medications, supplements, or herbal products you are currently taking, as bempedoic acid may interact with other drugs. This includes both prescription and over-the-counter medications.
• Laboratory tests: Your healthcare provider may order blood tests to monitor your liver function or check your cholesterol levels during treatment with bempedoic acid. Follow their instructions for any necessary laboratory tests.
• Lifestyle modifications: Bempedoic acid is typically used as part of a comprehensive approach to managing high cholesterol. Along with medication, your healthcare provider may recommend dietary modifications, regular exercise, and lifestyle changes to optimize cholesterol management.

Always consult your healthcare provider or pharmacist for specific instructions, advice, and any additional information regarding the use of bempedoic acid based on your individual circumstances.