Why is this medication prescribed?

Nexavar (generic name sorafenib) is a prescription medication used to treat certain types of cancer. It is classified as a targeted therapy and belongs to a class of drugs called kinase inhibitors. Nexavar is primarily prescribed for the treatment of the following types of cancer:

• Renal Cell Carcinoma (RCC): It is used to treat advanced renal cell carcinoma, which is a type of kidney cancer.
• Hepatocellular Carcinoma (HCC): Nexavar is indicated for the treatment of advanced hepatocellular carcinoma, the most common type of liver cancer.
• Thyroid Carcinoma: It is also used to treat locally advanced or metastatic, progressive differentiated thyroid carcinoma (papillary or follicular).

How should this medicine be used?

Nexavar is usually available in the form of oral tablets. The dosage and treatment schedule will depend on the specific type of cancer being treated and the patient’s individual medical condition. It’s essential to follow your doctor’s instructions and the prescribed dosage carefully.

The tablets are generally taken orally with water, with or without food. It’s recommended not to crush or chew the tablets and to swallow them whole.

Please note that cancer treatment protocols and drug usage guidelines can change over time as new research and clinical trials provide more information. Always consult a qualified healthcare professional for the most up-to-date and personalized advice regarding the use of Nexavar or any other medication. If you have been prescribed Nexavar, your doctor will explain the proper usage and any potential side effects associated with the medication.

Other uses for this medicine

Besides its primary use as a pain reliever and anti-inflammatory, Ketoprofen is also sometimes used in veterinary medicine to treat pain and inflammation in animals.

What special precautions should I follow?

Special Precautions for Ketoprofen Use:

• Liver Function: Before starting Nexavar treatment, the patient’s liver function should be evaluated. Liver function tests may be conducted regularly during treatment to monitor any changes or potential liver toxicity.
• Blood Pressure Monitoring: Nexavar may cause an increase in blood pressure. Regular monitoring of blood pressure is essential during treatment, and antihypertensive medications may be prescribed to control elevated blood pressure.
• Cardiac Function: Patients with a history of heart disease or risk factors for heart problems should be carefully monitored during treatment with Nexavar. It can cause cardiac side effects, including heart failure.
• Bleeding: Nexavar may lead to an increased risk of bleeding, especially in patients with underlying bleeding disorders or those taking anticoagulant medications.
• Skin Reactions: Some patients may experience skin reactions, such as hand-foot skin reaction (palmar-plantar erythrodysesthesia), rash, or desquamation (skin peeling). Proper skincare and management of skin reactions are important.
• Hypocalcemia: Patients with thyroid carcinoma treated with Nexavar may experience hypocalcemia (low calcium levels), so monitoring of calcium levels and appropriate supplementation may be necessary.
• Wound Healing: Nexavar may interfere with wound healing, so it is generally recommended to stop treatment before planned surgery. The decision to restart Nexavar after surgery should be made by the treating physician.
• Pregnancy and Contraception: Nexavar can cause harm to a developing fetus, so it is not recommended during pregnancy. Adequate contraception should be used during Nexavar treatment and for at least two weeks after the last dose in both male and female patients of reproductive potential.
• Interactions: Nexavar can interact with other medications, including certain drugs metabolized by the liver’s cytochrome P450 system. Inform your doctor about all the medications and supplements you are taking to avoid potential interactions.

As with any medication, it’s essential to follow your doctor’s instructions, report any side effects or concerns, and attend all recommended medical appointments during Nexavar treatment. Your healthcare team will closely monitor your response to treatment and make necessary adjustments to ensure your safety.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Nexavar (sorafenib). However, it’s always best to consult your healthcare provider or pharmacist for personalized advice based on your medical condition and any potential interactions with food.

What should I do if I forget a dose?

Regarding missed doses of Nexavar:

If you miss a dose and it is within 12 hours of the scheduled time:

• Take the missed dose as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.

If you miss a dose and it is more than 12 hours past the scheduled time:

• Skip the missed dose and wait until the next scheduled dose. Do not take a double dose to make up for the missed one.

What side effects can this medication cause?

Nexavar (sorafenib) can cause various side effects, which can vary in severity and may affect different individuals differently. It’s essential to understand that not all patients will experience these side effects, and some may experience only mild symptoms. It’s crucial to discuss potential side effects with your healthcare provider before starting Nexavar treatment. Some of the common side effects of Nexavar include:

• Fatigue: Feeling tired or weak is a common side effect of Nexavar.
• Diarrhea: Some patients may experience diarrhea during treatment.
• Hand-Foot Skin Reaction: This is a specific skin side effect characterized by redness, tenderness, and peeling of the skin on the palms of the hands and soles of the feet (palmar-plantar erythrodysesthesia). This can be managed with proper skincare.
• Skin Rash: Patients may develop a skin rash during treatment.
• Hypertension (High Blood Pressure): Nexavar can lead to an increase in blood pressure. Blood pressure should be monitored regularly during treatment.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting.
• Loss of Appetite: Nexavar can lead to a decrease in appetite.
• Abdominal Pain: Some patients may experience abdominal discomfort or pain.
• Hair Loss: Nexavar treatment may cause hair thinning or hair loss (alopecia).
• Weight Loss: Unintended weight loss may occur during Nexavar treatment.
• Voice Changes: In some cases, patients may experience hoarseness or changes in their voice.
• Infections: Nexavar can lower the body’s ability to fight infections, making patients more susceptible to infections.
• Wound Healing Issues: Nexavar may interfere with wound healing. It is generally recommended to stop treatment before planned surgery.
• Bleeding: Some patients may experience an increased risk of bleeding, especially in those with a history of bleeding disorders or those taking anticoagulant medications.
• Cardiac Side Effects: Rarely, Nexavar can cause cardiac side effects, including heart failure.

It’s important to report any side effects you experience during Nexavar treatment to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust the treatment plan if necessary to improve your overall experience with the medication. Remember that this list is not exhaustive, and other side effects may occur. Always consult your doctor for personalized information and advice related to your specific medical condition.

What should I know about storage and disposal of this medication?

Storage and Disposal of Nexavar:

• Store Nexavar tablets at room temperature, away from heat, moisture, and direct light.
• Keep the medication in its original container with the lid tightly closed.
• Keep Nexavar out of reach of children and pets.
• Do not use Nexavar tablets after the expiration date mentioned on the packaging.
• If you have any unused or expired Nexavar tablets, follow your local regulations and guidelines for safe disposal. Do not flush medications down the toilet or pour them into drains unless instructed to do so.

In case of emergency/overdose

In the event of an overdose or if you suspect someone has taken more Nexavar than prescribed, immediately seek medical attention or contact your local Poison Control Center. Overdosing on Nexavar can increase the risk of severe side effects and complications, and prompt medical intervention is essential.

What other information should I know?

• Nexavar is a potent medication used to treat specific types of cancer. It is important to take the medication exactly as prescribed by your healthcare provider. Do not change the dosage or stop the treatment without consulting your doctor.
• Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as they may interact with Nexavar.
• Attend all scheduled medical appointments and follow-up visits to monitor your progress and discuss any concerns or side effects with your healthcare team.
• Nexavar treatment may require regular blood tests and monitoring of liver function, blood pressure, and other parameters to ensure your safety and the effectiveness of the treatment.
• Use appropriate contraception during Nexavar treatment and for at least two weeks after the last dose, as the medication can be harmful to a developing fetus.
• Inform your healthcare provider if you have a history of heart problems, bleeding disorders, or liver disease before starting Nexavar treatment.
• Avoid grapefruit and grapefruit juice while taking Nexavar, as they may interact with the medication and affect its effectiveness.
• Nexavar can cause dizziness or tiredness. Avoid driving or operating heavy machinery if you experience these side effects.
• In case of any new or worsening symptoms, adverse reactions, or concerns during Nexavar treatment, contact your healthcare provider immediately.

Always follow your healthcare provider’s instructions and guidance during Nexavar treatment. Your medical team is there to support you and ensure that you have the best possible outcome while using this medication. If you have any questions or uncertainties, don’t hesitate to reach out to your doctor for clarification and assistance.