Why is this medication prescribed?

Neratinib is a prescription medication that is used for the treatment of certain types of breast cancer. It is specifically indicated for adult patients with early-stage, HER2-positive breast cancer who have previously completed treatment with trastuzumab (Herceptin) therapy.

HER2-positive breast cancer is a type of breast cancer where the cancer cells have an overexpression of a protein called human epidermal growth factor receptor 2 (HER2). This protein promotes the growth and division of cancer cells. Neratinib is classified as a kinase inhibitor, which means it works by blocking specific enzymes called tyrosine kinases, including HER2. By inhibiting HER2, neratinib helps to slow down or stop the growth of HER2-positive breast cancer cells.

Neratinib is typically used as an adjuvant treatment, meaning it is given after the primary treatment such as surgery or chemotherapy to reduce the risk of cancer recurrence. It is usually taken orally in the form of tablets. It is important to note that the use of neratinib should be discussed with a healthcare professional, who can evaluate the specific circumstances and determine the most appropriate treatment plan for an individual patient.

How should this medicine be used?

Neratinib is typically taken orally in the form of tablets. Here are some general guidelines for how it is commonly used:

• Dosage: The recommended dose of neratinib is 240 mg (six tablets) taken once daily. It is important to follow the prescribed dosage provided by your healthcare professional.
• Timing: Neratinib is usually taken with food. It is recommended to take neratinib at approximately the same time every day.
• Duration: The duration of neratinib treatment can vary depending on individual circumstances and the specific treatment plan recommended by your healthcare professional. It is important to continue taking neratinib for the prescribed duration unless otherwise instructed by your doctor.
• Adherence: It is important to take neratinib exactly as prescribed by your healthcare professional. Do not skip doses or adjust the dosage without consulting your doctor.
• Side effects: Neratinib may cause side effects, and it is essential to be aware of potential adverse reactions. Common side effects may include diarrhea, nausea, vomiting, fatigue, decreased appetite, and rash. If you experience any severe or persistent side effects, it is important to inform your healthcare professional.
• Follow-up: Regular follow-up visits with your doctor are important during neratinib treatment. Your doctor will monitor your response to the medication and assess any potential side effects.

Remember, these are general guidelines, and it is crucial to follow the specific instructions provided by your healthcare professional for your unique situation. They will provide you with detailed instructions on how to take neratinib, including any additional precautions or recommendations based on your individual needs.

Other uses for this medicine

In addition to its primary use in the treatment of HER2-positive breast cancer, neratinib is currently being investigated for other potential uses. Some of these investigational uses include:

• Metastatic HER2-positive breast cancer: Neratinib is being studied as a treatment option for patients with metastatic HER2-positive breast cancer who have progressed on prior HER2-targeted therapies.
• HER2-positive breast cancer prevention: Research is ongoing to evaluate the use of neratinib as a preventive therapy for individuals at high risk of developing HER2-positive breast cancer, such as those with a history of precancerous breast lesions or a strong family history of the disease.

What special precautions should I follow?

Regarding special precautions for neratinib, here are a few key points to consider:

• Pregnancy and breastfeeding: Neratinib may cause harm to an unborn baby, so it is important to inform your doctor if you are pregnant or planning to become pregnant. Similarly, it is advised to avoid breastfeeding while taking neratinib.
• Liver function: Neratinib may cause liver toxicity. Your healthcare provider may monitor your liver function through blood tests during treatment.
• Diarrhea: Diarrhea is a common side effect of neratinib. Your doctor may provide you with instructions on how to manage diarrhea and may prescribe medications to help control it.
• Drug interactions: Neratinib can interact with other medications, including certain antibiotics, antifungal agents, and acid-reducing medications. Inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting neratinib.
• Pre-existing medical conditions: Inform your healthcare provider about any pre-existing medical conditions you have, especially if you have a history of liver disease or gastrointestinal disorders.

It is important to discuss all your medical history, current medications, and any concerns you have with your healthcare professional before starting treatment with neratinib. They will provide you with personalized guidance and monitor your health throughout the course of treatment.

What special dietary instructions should I follow?

Neratinib is a medication used in the treatment of breast cancer. While there are no specific dietary restrictions associated with neratinib, it is generally recommended to take the medication with food. This can help reduce the likelihood of certain gastrointestinal side effects, such as nausea and diarrhea, which are common with neratinib use.

What should I do if I forget a dose?

If you forget to take a dose of neratinib, it is generally advised to take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, it is better to skip the missed dose and resume your regular dosing schedule. It is important not to take a double dose to make up for a missed one.

What side effects can this medication cause?

Neratinib, like any medication, can cause side effects. The most commonly reported side effects of neratinib include:

• Diarrhea: Diarrhea is one of the most common side effects of neratinib. It can range from mild to severe. Your healthcare provider may prescribe medications or recommend strategies to manage diarrhea, such as anti-diarrheal agents, dietary changes, and increased fluid intake.
• Nausea and vomiting: Neratinib can cause nausea and vomiting, which can often be managed with anti-nausea medications. Taking neratinib with food as recommended may help reduce these side effects.
• Fatigue: Feeling tired or experiencing fatigue is another common side effect. It is important to get enough rest and seek support from your healthcare team to manage fatigue.
• Decreased appetite: Some people may experience a decrease in appetite while taking neratinib. It’s important to try and maintain a balanced diet and discuss any significant changes in appetite with your healthcare provider.
• Abdominal pain: Abdominal pain or discomfort can occur with neratinib use. If the pain is severe or persistent, it’s important to notify your healthcare provider.
• Joint pain and muscle pain: Neratinib can cause joint pain and muscle pain. These symptoms can usually be managed with over-the-counter pain relievers or other strategies recommended by your healthcare provider.
• Skin rash: Some individuals may develop a rash while taking neratinib. Inform your healthcare provider if you experience any rash or skin changes.

It’s important to note that not everyone will experience these side effects, and some individuals may experience additional or different side effects. It’s essential to discuss any concerns or side effects you may experience with your healthcare provider, as they can provide guidance and support to manage them effectively.

What should I know about storage and disposal of this medication?

• Storage: Store Neratinib at room temperature, typically between 20°C to 25°C (68°F to 77°F). Keep the medication in its original container, tightly closed, and away from moisture and direct sunlight. Avoid storing it in the bathroom or any other area with high humidity or temperature fluctuations.
• Disposal: It is important to dispose of unused or expired Neratinib properly. Do not flush it down the toilet or pour it down the drain unless instructed to do so. Instead, consult with your healthcare provider or pharmacist about the appropriate disposal method in your area. They can provide guidance on how to safely dispose of the medication.

In case of emergency/overdose

In case of an emergency or overdose, immediately contact your local emergency services or go to the nearest emergency room. It is helpful to have the medication container or packaging with you so that medical professionals can identify the specific drug taken.

What other information should I know?

• Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and any herbal supplements.
• Let your healthcare provider know if you have any medical conditions, such as liver or kidney problems, or a history of heart disease.
• Attend all scheduled appointments with your healthcare provider to monitor your progress and discuss any concerns or side effects.
• It is important to take Neratinib exactly as prescribed by your healthcare provider. Do not change the dose or stop taking it without consulting them first.
• If you are pregnant or planning to become pregnant, discuss the potential risks and benefits of Neratinib with your healthcare provider. Similarly, if you are breastfeeding, talk to your healthcare provider regarding the safety of the medication for your child.

Remember, this information is not exhaustive, and it is crucial to consult your healthcare provider or pharmacist for specific instructions and guidance related to your individual situation and treatment with Neratinib. They can provide you with the most accurate and up-to-date information.