Why is this medication prescribed?

Naldemedine tosylate is a medication used to treat opioid-induced constipation (OIC) in adults who are taking opioid medications for chronic pain that is not caused by cancer. OIC is a common side effect of opioid use and can cause significant discomfort and difficulty in passing bowel movements.

Naldemedine tosylate works by blocking the effect of opioids in the gastrointestinal tract, thereby reducing constipation. It belongs to a class of medications known as peripherally acting mu-opioid receptor antagonists (PAMORAs).

How should this medicine be used?

The medication is usually prescribed by a healthcare professional and should be taken exactly as directed. The recommended dose of naldemedine tosylate is 0.2 milligrams (mg) once daily. It can be taken with or without food. It is important to follow the instructions provided by your healthcare provider and not exceed the prescribed dosage.

If you have any questions or concerns about the use of naldemedine tosylate, it is best to consult with your healthcare provider for personalized advice. They can provide you with the most appropriate dosage and instructions based on your specific condition and medical history.

Other uses for this medicine

Naldemedine tosylate is primarily used for the treatment of opioid-induced constipation (OIC) in adults. However, it is important to note that medications are prescribed at the discretion of healthcare professionals, and they may occasionally recommend off-label uses based on their clinical judgment and the specific needs of the patient.

What special precautions should I follow?

Regarding special precautions for naldemedine tosylate, here are some important points to consider:

• Allergies: Inform your healthcare provider if you have any known allergies or hypersensitivity to naldemedine tosylate or any of its components. This medication may contain inactive ingredients that can cause allergic reactions or other adverse effects.
• Pre-existing Conditions: Discuss your medical history with your healthcare provider, especially if you have any pre-existing conditions such as severe hepatic impairment or any gastrointestinal disorders. These conditions may affect the safety and efficacy of naldemedine tosylate.
• Pregnancy and Breastfeeding: It is important to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of naldemedine tosylate during pregnancy or lactation has not been established, and the potential risks and benefits should be carefully evaluated by your healthcare provider.
• Drug Interactions: Naldemedine tosylate may interact with other medications you are taking. Provide a complete list of all prescription drugs, over-the-counter medications, herbal products, and supplements to your healthcare provider. Certain medications, such as strong cytochrome P450 3A4 inhibitors or inducers, may affect the metabolism of naldemedine tosylate.
• Side Effects: Like any medication, naldemedine tosylate may cause side effects. Common side effects can include abdominal pain, diarrhea, nausea, and vomiting. If you experience severe or persistent side effects, contact your healthcare provider.

It is crucial to follow your healthcare provider’s instructions and consult with them for personalized advice regarding the use of naldemedine tosylate, as they can assess your specific medical situation and provide guidance tailored to your needs.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of naldemedine tosylate. You can take the medication with or without food according to your preference or as directed by your healthcare provider. However, it’s always a good idea to maintain a healthy and balanced diet to support overall gastrointestinal health.

What should I do if I forget a dose?

If you forget to take a dose of naldemedine tosylate, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Naldemedine tosylate, like any medication, can potentially cause side effects. Not all individuals will experience these side effects, and their severity can vary. Common side effects associated with naldemedine tosylate include:

• Abdominal pain: This can manifest as discomfort, cramping, or a generalized pain in the abdominal area.
• Diarrhea: Naldemedine tosylate may lead to increased bowel movements and loose stools.
• Nausea: Some individuals may experience a sensation of queasiness or an urge to vomit.
• Gastrointestinal gas: Flatulence or an increase in the passage of gas may occur.
• Vomiting: In some cases, naldemedine tosylate may induce vomiting.
• Headache: A mild to moderate headache may occur as a side effect.

It is important to note that these side effects are not exhaustive, and other less common or rare side effects may also occur. If you experience any unusual or severe side effects while taking naldemedine tosylate, it is important to contact your healthcare provider for further evaluation and guidance.

Additionally, it is worth mentioning that individual responses to medications can vary, and not everyone will experience side effects. Your healthcare provider can provide more personalized information about the potential side effects of naldemedine tosylate based on your specific medical history and condition.

What should I know about storage and disposal of this medication?

• Storage: Store Naldemedine Tosylate at room temperature, away from excessive heat, moisture, and direct light. Follow the specific storage instructions provided by the manufacturer or your pharmacist.
• Disposal: Properly dispose of unused or expired Naldemedine Tosylate in accordance with local guidelines and regulations. Do not flush medications down the toilet or pour them into drains unless instructed to do so. Consult your pharmacist or local waste disposal authority for guidance on the safe disposal of medications.

In case of emergency/overdose

In case of an emergency or suspected overdose, such as the ingestion of too much Naldemedine Tosylate, immediately contact your local emergency services or go to the nearest emergency room. It is helpful to carry the medication packaging or label with you to provide necessary information to the healthcare professionals.

What other information should I know?

• Keep all medications, including Naldemedine Tosylate, out of reach of children and pets.
• Inform your healthcare provider about all the medications, supplements, or herbal products you are taking to avoid potential interactions.
• Attend regular check-ups with your healthcare provider to monitor the effectiveness and safety of Naldemedine Tosylate.
• Follow your healthcare provider’s instructions and dosage recommendations strictly.
• If you have any specific questions or concerns about Naldemedine Tosylate, consult your healthcare provider or pharmacist for further clarification.

It’s important to note that the information provided here is a general overview, and it’s always advisable to follow the specific instructions provided by your healthcare provider and the medication’s packaging.