Why is this medication prescribed?

Naldemedine is a medication that is prescribed for the treatment of opioid-induced constipation (OIC) in adult patients who have chronic non-cancer pain. OIC is a common side effect of opioid pain medications, and it refers to constipation that occurs as a result of opioid use.

Naldemedine belongs to a class of drugs called peripherally acting mu-opioid receptor antagonists (PAMORAs). It works by blocking the effects of opioids in the gastrointestinal tract, specifically the mu-opioid receptors, which helps to restore normal bowel function and relieve constipation.

How should this medicine be used?

When using Naldemedine, it is important to follow the instructions provided by your healthcare provider. Typically, the recommended dose is 0.2 milligrams (mg) once daily. It can be taken with or without food. It is important to swallow the tablet whole and not crush, chew, or break it. If you have difficulty swallowing, you should inform your doctor.

It’s important to note that Naldemedine is a prescription medication, and you should consult your healthcare provider for specific dosing instructions and any other questions or concerns you may have about its use. They will consider your individual condition and medical history to determine the appropriate dosage for you.

Other uses for this medicine

Naldemedine is primarily prescribed for the treatment of opioid-induced constipation (OIC) in patients with chronic non-cancer pain. Currently, this is the only approved use for Naldemedine.

What special precautions should I follow?

As for special precautions, there are several important considerations to keep in mind when using Naldemedine:

• Allergies: Inform your healthcare provider if you have any known allergies to Naldemedine or any of its ingredients. Allergic reactions to medications can be serious and may require immediate medical attention.
• Medication Interactions: Naldemedine may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. It is important to inform your doctor about all the medications, supplements, and herbal products you are taking before starting Naldemedine. They can evaluate potential interactions and adjust your treatment plan accordingly.
• GI Disorders: If you have any known or suspected gastrointestinal (GI) disorders, such as Crohn’s disease or diverticulitis, it is important to discuss this with your healthcare provider. Naldemedine may not be suitable or may require special monitoring in such cases.
• Pregnancy and Breastfeeding: The safety of Naldemedine during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, it is essential to discuss the potential risks and benefits of Naldemedine with your healthcare provider.
• Side Effects: Like any medication, Naldemedine can cause side effects. Common side effects may include stomach pain, diarrhea, nausea, and vomiting. If you experience severe or persistent side effects, it is important to inform your doctor.
• Other Medical Conditions: Inform your healthcare provider about any other medical conditions you have, especially if you have a history of bowel obstruction, have had recent abdominal surgery, or have a known or suspected gastrointestinal disorder. These factors may influence the suitability and dosing of Naldemedine.

Remember, it is important to consult with your healthcare provider for personalized advice and guidance regarding the use of Naldemedine. They can assess your specific situation and provide you with the most accurate and up-to-date information.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of Naldemedine. You can take Naldemedine with or without food, according to your preference. However, it’s generally recommended to maintain a healthy and balanced diet to support overall digestive health.

What should I do if I forget a dose?

If you forget to take a dose of Naldemedine, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Naldemedine may cause side effects in some individuals. Common side effects that have been reported with the use of Naldemedine include:

• Stomach pain
• Diarrhea
• Nausea
• Flatulence (excessive gas)
• Vomiting
• Headache

These side effects are generally mild and temporary, and they often improve on their own as your body adjusts to the medication. However, if these side effects persist or become severe, it is important to notify your healthcare provider.

In rare cases, more serious side effects may occur. Although uncommon, it is crucial to seek medical attention immediately if you experience any of the following:

• Severe or persistent abdominal pain or discomfort
• Severe or persistent diarrhea
• Severe or persistent nausea or vomiting
• Signs of an allergic reaction, such as rash, itching, swelling, dizziness, or difficulty breathing

It’s important to note that this list is not exhaustive, and other side effects may occur. If you experience any unusual or bothersome symptoms while taking Naldemedine, contact your healthcare provider for further evaluation and guidance.

Always consult your healthcare provider for personalized advice regarding the potential side effects of Naldemedine and how to manage them. They can provide you with specific information based on your medical history and individual circumstances.

What should I know about storage and disposal of this medication?

• Storage: Store Naldemedine at room temperature, away from excessive heat, moisture, and direct sunlight. Keep it in its original container, tightly closed, and out of reach of children and pets.
• Disposal: Dispose of unused or expired Naldemedine properly. Do not flush it down the toilet or pour it into drains unless instructed to do so by local regulations. Contact your pharmacist or local waste disposal facility for guidance on how to safely dispose of the medication.

In case of emergency/overdose

• If someone has overdosed and is experiencing severe symptoms or is unconscious, call emergency services immediately.
• If possible, provide the emergency medical personnel with information about the medication taken, including the name (Naldemedine) and the amount ingested.

What other information should I know?

• Regular Follow-up: Attend all scheduled appointments with your healthcare provider to monitor your response to Naldemedine and to address any concerns or questions you may have.
• Medication Compliance: Take Naldemedine exactly as prescribed by your healthcare provider. Do not increase or decrease the dosage or stop taking it without consulting your doctor.
• Drug Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as certain medications may interact with Naldemedine and affect its efficacy or increase the risk of side effects.
• Medical Conditions: Inform your healthcare provider about any existing medical conditions you have, especially any gastrointestinal disorders, as they may affect the use of Naldemedine.
• Keep a List: Maintain a list of all the medications you are taking, including their names, dosages, and frequencies. Carry this list with you and share it with your healthcare provider and pharmacist during each visit.

Remember, the information provided here is not exhaustive, and it’s crucial to consult your healthcare provider or pharmacist for comprehensive instructions, guidance, and any specific information related to your individual circumstances and the use of Naldemedine.