WARNING

Metozolv ODT is a medication primarily used to treat gastrointestinal conditions like gastroesophageal reflux disease (GERD) and gastroparesis. While it can be effective in managing these conditions, it also comes with certain risks and potential side effects. Here are some of the key risks associated with taking Metozolv ODT:

• Side Effects: Common side effects may include drowsiness, dizziness, headache, and diarrhea. These side effects can impair your ability to drive or operate heavy machinery.
• Serotonin Syndrome: Metozolv ODT can interact with other drugs that affect serotonin levels, potentially leading to a rare but serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and tremors.
• Neuroleptic Malignant Syndrome (NMS): Although rare, Metozolv ODT may increase the risk of NMS, a potentially life-threatening condition characterized by high fever, muscle rigidity, altered mental status, and autonomic dysfunction.
• Cardiovascular Effects: This medication may cause changes in heart rhythm (QT prolongation) which can be dangerous, especially when taken with other medications that also affect heart rhythm. It’s essential to inform your healthcare provider of all the medications you are taking.
• Allergic Reactions: Some individuals may experience allergic reactions to Metozolv ODT, such as skin rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you notice any signs of an allergic reaction.
• Gastrointestinal Issues: In rare cases, Metozolv ODT may exacerbate certain gastrointestinal conditions, such as bowel obstructions or perforations.
• Mental Health Effects: Some patients may experience changes in mood, behavior, or thoughts while taking Metozolv ODT. Be sure to report any unusual mental health symptoms to your healthcare provider.
• Interactions: Metozolv ODT can interact with other medications you may be taking, potentially reducing their effectiveness or increasing the risk of side effects.

It’s crucial to take Metozolv ODT exactly as prescribed by your healthcare provider and to inform them of your medical history and any other medications you’re taking. They can help assess the risks and benefits of this medication in your specific case and monitor you for potential side effects. If you experience any severe or concerning side effects, seek medical attention promptly. This information is intended as a general overview, and individual experiences with this medication may vary, so always consult with your healthcare provider for personalized guidance.

Why is this medication prescribed?

Metozolv ODT is prescribed primarily to treat certain gastrointestinal conditions. It contains the active ingredient metoclopramide, which works by increasing the movement of the stomach and intestines to help food move more easily through the digestive system. Here are some of the common conditions for which Metozolv ODT may be prescribed:

• Gastroesophageal Reflux Disease (GERD): It can be used to manage symptoms of GERD, such as heartburn, acid reflux, and regurgitation.
• Gastroparesis: Metozolv ODT may be prescribed for individuals with gastroparesis, a condition where the stomach muscles don’t function properly, leading to delayed emptying of the stomach.
• Nausea and Vomiting: It is sometimes used to relieve symptoms of nausea and vomiting, often associated with chemotherapy, radiation therapy, or surgical procedures.
• Diabetic Gastroparesis: In diabetic patients, gastroparesis can be a complication of diabetes, and Metozolv ODT may help improve stomach emptying in such cases.

How should this medicine be used?

Here are some general guidelines for how Metozolv ODT should be used:

• Dosage: Follow your healthcare provider’s instructions carefully regarding the dosage and frequency of Metozolv ODT. The dosage can vary depending on your specific condition.
• Administration: Metozolv ODT is an orally disintegrating tablet that dissolves on the tongue without the need for water. Place the tablet on your tongue, let it dissolve, and then swallow it. It is typically taken before meals and at bedtime, but follow your doctor’s recommendations.
• Timing: Take Metozolv ODT at the prescribed times to maximize its effectiveness in aiding digestion or reducing symptoms.
• Duration: Use Metozolv ODT for the duration recommended by your healthcare provider, even if your symptoms improve. Do not stop taking it abruptly without consulting your doctor, as this can lead to a rebound increase in symptoms.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Metozolv ODT can interact with other drugs.
• Special Considerations: Your doctor will consider your medical history, current medications, and the specific gastrointestinal condition you have when prescribing Metozolv ODT. It may not be suitable for everyone, so be sure to discuss any concerns or potential side effects with your healthcare provider.

It’s crucial to use Metozolv ODT exactly as prescribed and to communicate any changes in your symptoms or any side effects you experience with your healthcare provider. This medication should be part of a comprehensive treatment plan for your gastrointestinal condition, which may also include dietary and lifestyle modifications.

Other uses for this medicine

While Metozolv ODT is primarily used for GI conditions, it is sometimes prescribed off-label for other purposes. Some healthcare providers may use it for conditions such as:

• Migraines: In some cases, metoclopramide (the active ingredient in Metozolv ODT) may be used to treat migraines, particularly if other treatments have not been effective.
• Gastroparesis: Gastroparesis is a condition where the stomach doesn’t empty food properly. Metoclopramide may be prescribed to help improve stomach emptying in people with gastroparesis.

What special precautions should I follow?

As for special precautions when using Metozolv ODT, here are some important considerations:

• Medical History: Inform your healthcare provider of your complete medical history, including any allergies, past or current medical conditions, and a history of gastrointestinal surgery.
• Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the risks and benefits of using Metozolv ODT with your healthcare provider. This medication may pass into breast milk and affect the infant.
• Driving and Operating Machinery: Metoclopramide can cause drowsiness and dizziness, so avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how this medication affects you.
• Drug Interactions: Be sure to inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Metozolv ODT can interact with certain drugs, potentially leading to adverse effects.
• Long-Term Use: Avoid long-term or excessive use of Metozolv ODT unless directed by your healthcare provider, as it may lead to a risk of developing tardive dyskinesia, a movement disorder.
• Allergic Reactions: If you experience signs of an allergic reaction (e.g., rash, itching, swelling, severe dizziness, difficulty breathing) after taking Metozolv ODT, seek immediate medical attention.

Always follow your healthcare provider’s instructions regarding the use of Metozolv ODT and report any unusual or severe side effects promptly. This information is intended as a general guideline, and individual precautions may vary based on your specific medical history and circumstances.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Metozolv ODT. However, to help manage the symptoms of nausea or vomiting that you may be taking this medication for, consider these dietary tips:

• Small, Frequent Meals: Eating smaller, more frequent meals throughout the day can help manage nausea and vomiting.
• Avoid Trigger Foods: If certain foods or smells trigger your symptoms, try to avoid them.
• Stay Hydrated: Ensure you are well-hydrated, especially if vomiting has led to dehydration. Sip on clear fluids like water, ginger tea, or clear broths.
• Ginger and Peppermint: Some people find relief from nausea by consuming ginger or peppermint in various forms, such as tea or candies. These can be included in your diet as well.

What should I do if I forget a dose?

If you forget to take a dose of Metozolv ODT:

• Take It as Soon as Possible: If you miss a dose and remember it shortly after the scheduled time, take it as soon as you remember.
• Skip If Close to Next Dose: If it’s close to the time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not double up on doses to make up for a missed one, as this can increase the risk of side effects.
• Consult Your Healthcare Provider: If you are unsure about what to do when you miss a dose or if you frequently miss doses, contact your healthcare provider for guidance. They can provide specific instructions based on your individual treatment plan.

What side effects can this medication cause?

Metozolv ODT (metoclopramide) can cause a range of side effects, some of which can be mild, while others may be more severe. It’s important to be aware of these potential side effects when taking the medication and to promptly inform your healthcare provider if you experience any of them. Common side effects of Metozolv ODT include:

• Drowsiness: Many people taking Metozolv ODT may experience drowsiness, which can affect your ability to drive or operate machinery.
• Dizziness: Some individuals may feel dizzy while taking this medication.
• Headache: Headaches are a common side effect of Metozolv ODT.
• Diarrhea: This medication can sometimes lead to diarrhea.
• Restlessness: You may feel restless or have difficulty sitting still.
• Fatigue: Feeling tired or fatigued is another possible side effect.
• Nervousness or Anxiety: Metozolv ODT may cause feelings of nervousness or anxiety in some individuals.
• Insomnia: Difficulty falling asleep or staying asleep can occur.
• Increased Risk of Depression: In some cases, this medication has been associated with an increased risk of depression or exacerbation of existing depression.
• Movement Disorders: In rare cases, Metozolv ODT can lead to movement disorders, including tardive dyskinesia, which involves involuntary muscle movements, often of the face or limbs.
• Serious Allergic Reactions: Although rare, serious allergic reactions to metoclopramide can occur. Seek immediate medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Heart Rhythm Changes: Metoclopramide can cause changes in heart rhythm (QT prolongation), which can be serious, especially when taken with other medications that also affect heart rhythm.
• Neuroleptic Malignant Syndrome (NMS): While rare, metoclopramide has been associated with the risk of NMS, a potentially life-threatening condition characterized by high fever, muscle rigidity, altered mental status, and autonomic dysfunction.

It’s essential to report any unusual or severe side effects to your healthcare provider promptly. If you experience signs of a serious allergic reaction or any symptoms of NMS, seek immediate medical attention.

Keep in mind that the benefits of Metozolv ODT in managing your specific medical condition should be weighed against the potential risks and side effects. Your healthcare provider will monitor your response to the medication and adjust your treatment plan as needed to ensure your safety and well-being.

What should I know about storage and disposal of this medication?

Regarding storage and disposal, here are some guidelines:

Storage:

• Store Metozolv ODT at room temperature, away from excessive heat, moisture, and light.
• Keep the medication in its original packaging or container to protect it from moisture and air.
• Keep it out of reach of children and pets.

Disposal:

• Do not keep unused or expired Metozolv ODT tablets. Ask your pharmacist or healthcare provider about the proper disposal of unused medication.
• Do not flush Metozolv ODT down the toilet or drain, unless specifically instructed to do so.

In case of emergency or suspicion of an overdose, take the following steps:

In case of an overdose or if you suspect someone has taken more Metozolv ODT than prescribed, contact emergency medical services (call 911 in the United States) or seek immediate medical attention. An overdose of metoclopramide can lead to serious symptoms, which may include:

• Confusion
• Drowsiness
• Uncontrollable movements or muscle spasms
• Tremors
• Seizures
• Hallucinations
• Difficulty breathing
• Loss of consciousness

What other information should I know

• Always take Metozolv ODT exactly as prescribed by your healthcare provider. Follow the dosing instructions carefully, and do not change the dose without consulting them.
• Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as there may be potential drug interactions with Metozolv ODT.
• If you experience any unusual or severe side effects, or if your symptoms worsen or do not improve while taking Metozolv ODT, contact your healthcare provider promptly.
• Do not drink alcohol while taking Metozolv ODT, as it can increase the risk of drowsiness and dizziness.
• Metozolv ODT may cause drowsiness and dizziness, so avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how this medication affects you.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Metozolv ODT with your healthcare provider. They can help weigh the risks and benefits and provide guidance on its use during pregnancy or while breastfeeding.
• Keep all appointments with your healthcare provider for monitoring and follow-up while taking Metozolv ODT.
• Do not share this medication with others, even if they have similar symptoms, as it may not be suitable or safe for them.
• If you have any concerns or questions about Metozolv ODT or your treatment plan, discuss them with your healthcare provider. They can provide you with personalized guidance and address your specific needs.

Always follow your healthcare provider’s recommendations and guidance when using Metozolv ODT to ensure its safe and effective use in managing your medical condition.