Why is this medication prescribed?

Mektovi (binimetinib) is a prescription medication used to treat certain types of cancer. It is primarily prescribed for patients with advanced melanoma (a type of skin cancer) that has specific genetic mutations, such as the BRAF V600E or V600K mutations. These mutations are known to drive the growth of melanoma cells, and Mektovi, when used in combination with another medication called Encorafenib (Braftovi), is designed to target and inhibit these mutated proteins, thereby slowing down or halting the progression of the cancer.

How should this medicine be used?

The usage and dosing of Mektovi should be determined by a healthcare professional, typically an oncologist, who will consider various factors, including the patient’s overall health, the specific type and stage of cancer, and any other medications the patient may be taking. In general, Mektovi is usually taken orally in the form of tablets.

The dosing and administration instructions can vary, but it’s important for patients to follow their healthcare provider’s guidance and the instructions provided with the medication precisely. It’s typically taken with or without food, depending on your healthcare provider’s recommendation. It’s essential to take the medication as prescribed and to not alter the dosing schedule without consulting your healthcare provider.

Additionally, like all medications, Mektovi can have side effects and potential interactions with other drugs, so it’s crucial for patients to communicate regularly with their healthcare team to monitor for any adverse effects and to ensure the treatment is working effectively.

Please note that medication information may change over time, and it’s essential to consult with a healthcare provider or pharmacist for the most up-to-date and specific guidance regarding the use of Mektovi or any other prescription medication.

Other uses for this medicine

Mektovi (binimetinib) is primarily used to treat specific types of advanced melanoma with certain genetic mutations, such as the BRAF V600E or V600K mutations. It is not typically used for other purposes or cancer types, as its mechanism of action is specifically designed to target these mutations in melanoma cells.

What special precautions should I follow?

Special precautions should be taken when using Mektovi, and it’s essential to follow your healthcare provider’s guidance and the medication’s specific instructions. Here are some important precautions to consider:

• Medical Supervision: Mektovi should only be used under the supervision of a healthcare provider experienced in the treatment of cancer. Your oncologist will determine if this medication is appropriate for your specific condition.
• Pregnancy and Contraception: Mektovi can cause harm to a developing fetus, so it’s essential to use effective contraception during treatment and for a period of time after the last dose. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of treatment with your healthcare provider.
• Liver Function: Mektovi may affect liver function, so your healthcare provider will likely monitor your liver enzymes during treatment. Notify your healthcare team if you experience signs of liver problems, such as yellowing of the skin or eyes, dark urine, or abdominal pain.
• Muscle Problems: This medication can also lead to muscle problems. Inform your healthcare provider if you experience muscle pain, weakness, or stiffness during treatment.
• Eye Problems: Some patients may develop eye problems while taking Mektovi, including vision changes or eye pain. Report any new or worsening eye symptoms to your healthcare provider.
• Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as Mektovi may interact with other drugs. Some interactions could affect the safety and effectiveness of the treatment.
• Allergies: Let your healthcare provider know if you have a history of allergies or hypersensitivity to any medications or their ingredients, as this may affect your ability to take Mektovi.
• Regular Check-ups: You will likely need regular check-ups and blood tests to monitor your progress and assess any potential side effects.
• Adherence: It’s crucial to take Mektovi exactly as prescribed by your healthcare provider. Do not skip doses or stop taking the medication without their guidance.

Remember that the information provided here is general, and your healthcare provider will provide you with personalized guidance and precautions based on your medical history and current health status. Always consult with your healthcare team for the most accurate and up-to-date information regarding the use of Mektovi and any specific precautions you should take.

What special dietary instructions should I follow?

Special dietary instructions for Mektovi (binimetinib) may not be necessary, but it’s important to follow your healthcare provider’s recommendations and any specific instructions provided with the medication. In general, you can usually take Mektovi with or without food, but your healthcare provider may have specific preferences based on your individual circumstances. If you have any concerns or questions about dietary instructions, be sure to discuss them with your healthcare provider or pharmacist.

What should I do if I forget a dose?

If you forget to take a dose of Mektovi, you should take it as soon as you remember, unless it’s close to the time for your next scheduled dose. If it’s close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects without providing any additional benefit.

What side effects can this medication cause?

Mektovi (binimetinib) is a prescription medication used in combination with encorafenib to treat certain types of advanced melanoma (a type of skin cancer) with specific genetic mutations. Like all medications, Mektovi can cause side effects. It’s essential to be aware of these potential side effects and follow your healthcare provider’s guidance while taking this medication. Here are some common side effects of Mektovi:

Common Side Effects:

• Nausea
• Diarrhea
• Vomiting
• Abdominal pain
• Rash
• Fatigue
• Swelling in the hands or feet
• Headache
• Muscle pain or weakness
• Fever
• Elevated blood pressure

Serious Side Effects: While less common, Mektovi can also cause more severe side effects, which require immediate medical attention. These may include:

• Severe rash with blistering, peeling, or itching
• Eye problems (such as blurred vision, increased tearing, or eye pain)
• Signs of bleeding (e.g., nosebleeds, unusual bruising, blood in urine or stools)
• Severe nausea, vomiting, or diarrhea that can lead to dehydration
• Severe abdominal pain
• Liver problems (e.g., jaundice, dark urine, pale stools)
• Signs of heart problems (e.g., chest pain, irregular heartbeat, shortness of breath)

It’s crucial to report any side effects you experience to your healthcare provider promptly. They can provide guidance on managing these side effects or adjust your treatment as necessary.

What should I know about storage and disposal of this medication?

Storage:

• Store at the Right Temperature: Mektovi should be stored at room temperature between 68°F and 77°F (20°C to 25°C).
• Keep Away from Moisture: Store the medication in its original container, and keep it away from moisture and excessive humidity.
• Keep Out of Reach of Children and Pets: Ensure that Mektovi is stored in a secure location where children and pets cannot access it.

Disposal:

• Do Not Flush: Do not flush Mektovi tablets down the toilet or dispose of them in household drains, as this can harm the environment.
• Follow Local Regulations: Dispose of unused or expired medications following your local regulations or guidelines. Many areas have medication take-back programs or provide instructions for safe disposal through household trash.
• Protect Privacy: Before disposing of the medication packaging, ensure that you remove or obscure any personal information to protect your privacy.

In case of emergency/overdose

In case of an emergency or suspected overdose with Mektovi, you should seek immediate medical attention or contact a poison control center at 1-800-222-1222. Be prepared to provide information about the medication and the amount ingested. Overdose symptoms may include severe diarrhea, vomiting, or other severe side effects.

What other information should I know

• Follow Your Healthcare Provider’s Instructions: Always take Mektovi as prescribed by your healthcare provider, and do not alter the dosing regimen without their guidance.
• Regular Monitoring: Your healthcare team will likely monitor your progress and assess for potential side effects during your treatment with Mektovi. Attend all scheduled appointments and communicate any concerns or changes in your health to your healthcare provider.
• Medication Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking to prevent potential interactions with Mektovi.
• Pregnancy and Contraception: If you are of childbearing age, discuss contraception options with your healthcare provider, as Mektovi can harm a developing fetus.
• Follow-Up Care: After completing your treatment with Mektovi, your healthcare provider will provide guidance on follow-up care and monitoring to assess your overall health and any potential recurrence of cancer.

Always consult with your healthcare provider or pharmacist for the most up-to-date and specific information about Mektovi and any other medications you are taking. They can provide personalized guidance and answer any questions or concerns you may have about your treatment plan.