Why is this medication prescribed?

Dalfampridine, marketed under the brand name Ampyra, is primarily prescribed to improve walking in adults with multiple sclerosis (MS). Multiple sclerosis is a chronic illness affecting the central nervous system, leading to symptoms such as muscle weakness, difficulty with coordination and balance, and problems with walking. Dalfampridine works by blocking potassium channels on nerve cells, which can enhance signal conduction and improve walking ability in some MS patients.

How should this medicine be used?

Dalfampridine, marketed under the brand name Ampyra, is a medication used to improve walking in patients with multiple sclerosis (MS). Here are the key guidelines for its use:

• Dosage: The typical dosage of Dalfampridine is 10 mg taken orally twice a day, approximately 12 hours apart. Do not take more than 20 mg in a 24-hour period.
• Administration: Swallow the tablets whole. Do not crush, chew, or break them. Take the medication with or without food. If you miss a dose, do not take an extra dose to make up for it. Wait until the next scheduled dose.
• Timing: Consistency in timing is important. Take the medication at the same times each day to maintain an even level in your bloodstream.
• Monitoring: Regularly follow up with your healthcare provider to monitor your progress and any side effects. Your kidney function may need to be tested before and during treatment, as Dalfampridine is excreted through the kidneys.
• Side Effects: Common side effects include urinary tract infections, insomnia, dizziness, headache, nausea, and weakness. Serious side effects can include seizures. If you experience a seizure, stop taking the medication and seek medical attention immediately.
• Precautions: Dalfampridine should not be used if you have a history of seizures or moderate to severe kidney impairment. Inform your healthcare provider of all medications you are taking, as Dalfampridine can interact with other drugs.
• Storage: Store the medication at room temperature, away from moisture and heat. Keep it out of reach of children.

Always use Dalfampridine under the supervision of a healthcare provider, and follow their specific instructions based on your individual health condition.

Other uses for this medicine

Dalfampridine (Ampyra) is primarily indicated for improving walking in patients with multiple sclerosis (MS). However, there may be some off-label uses for this medication, which would require careful consideration and consultation with a healthcare provider. Off-label uses could include conditions where enhanced nerve conduction might be beneficial, but these would need to be assessed on a case-by-case basis.

What special precautions should I follow?

As for special precautions to follow with Dalfampridine:

• Seizure Risk: Dalfampridine can lower the seizure threshold. It should not be used in patients with a history of seizures. If you have a seizure while taking Dalfampridine, discontinue the medication and seek medical attention immediately.
• Kidney Function: Dalfampridine is primarily excreted by the kidneys. It should be used with caution in patients with moderate to severe kidney impairment. Your kidney function may need to be monitored before and during treatment.
• Interactions: Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and herbal supplements, as Dalfampridine can interact with other drugs. Certain medications, such as other drugs that lower the seizure threshold, may increase the risk of seizures when taken with Dalfampridine.
• Pregnancy and Breastfeeding: The safety of Dalfampridine during pregnancy and breastfeeding has not been established. It should be used with caution in pregnant or breastfeeding women, and only if the potential benefits outweigh the potential risks.
• Allergic Reactions: If you have a known allergy to Dalfampridine or any of its ingredients, do not take this medication. Seek medical attention immediately if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Alcohol: Avoid excessive alcohol consumption while taking Dalfampridine, as it may increase the risk of side effects such as dizziness or drowsiness.

Always follow your healthcare provider’s instructions and discuss any concerns or questions you have about Dalfampridine before starting or continuing treatment.

What special dietary instructions should I follow?

• Food Intake: Dalfampridine can be taken with or without food. Consistency in how you take it (with meals or on an empty stomach) may help maintain stable drug levels in your body.
• Hydration: Stay well-hydrated, especially if you experience any urinary side effects.

What should I do if I forget a dose?

If you forget to take a dose of Dalfampridine:

• Skip the Missed Dose: If it’s almost time for your next dose, skip the missed dose.
• Do Not Double Dose: Do not take two doses at once to make up for the missed dose.
• Resume Regular Schedule: Continue with your regular dosing schedule from the next dose.

What side effects can this medication cause?

Dalfampridine (Ampyra) can cause a range of side effects, some of which are common and others that are less common but potentially serious. Here’s an overview:

Common side effects may include:

• Urinary Tract Infections: Increased frequency of urinary tract infections is a common side effect of Dalfampridine.
• Insomnia: Difficulty falling or staying asleep may occur.
• Dizziness: Some individuals may experience dizziness or lightheadedness, especially when standing up quickly.
• Headache: Headaches are a common side effect, though they are usually mild.
• Nausea: Some people may experience mild stomach discomfort or nausea.
• Weakness: A feeling of weakness or fatigue may occur.

Less common but potentially serious side effects may include:

• Seizures: Dalfampridine can lower the seizure threshold, increasing the risk of seizures, particularly in individuals with a history of seizures.
• Allergic Reactions: Although rare, allergic reactions to Dalfampridine can occur. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.
• Cardiovascular Effects: In some cases, Dalfampridine may cause cardiovascular effects such as palpitations or an increased heart rate. If you experience any unusual heart symptoms, contact your healthcare provider.
• Other Neurological Effects: Some individuals may experience other neurological side effects such as tremors, balance issues, or numbness and tingling sensations.

It’s essential to discuss any side effects you experience with your healthcare provider. They can provide guidance on managing side effects or adjusting your dosage if necessary. Additionally, if you experience any severe or concerning side effects, seek medical attention promptly.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store Dalfampridine tablets at room temperature, away from moisture and heat. Avoid storing them in the bathroom or kitchen where moisture levels can fluctuate. Keep the medication out of reach of children and pets.
• Disposal: Dispose of Dalfampridine tablets safely and responsibly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by a healthcare professional. Instead, follow any specific disposal instructions provided by your pharmacist or local waste disposal facility.

In case of emergency/overdose

• In Case of Emergency: If you or someone else experiences a medical emergency related to Dalfampridine, such as severe allergic reactions, seizures, or other serious symptoms, seek immediate medical attention by calling emergency services or visiting the nearest emergency room.
• Overdose: In the event of a suspected overdose of Dalfampridine, contact your local poison control center or emergency room immediately. Overdose symptoms may include seizures, severe dizziness, confusion, difficulty breathing, or loss of consciousness.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider while taking Dalfampridine. These appointments allow your doctor to monitor your progress, adjust your dosage if necessary, and address any concerns or side effects you may be experiencing.
• Regular Monitoring: Your healthcare provider may periodically assess your kidney function while you are taking Dalfampridine, especially if you have pre-existing kidney conditions or are at risk of kidney impairment.
• Avoid Alcohol: Limit or avoid alcohol consumption while taking Dalfampridine, as alcohol may increase the risk of side effects such as dizziness or drowsiness.
• Medical Alert Bracelet: If you have a history of seizures or other medical conditions that may require emergency treatment, consider wearing a medical alert bracelet or pendant to alert healthcare providers to your condition in case of emergencies.
• Patient Education: Stay informed about your medication by reading the medication guide provided by your pharmacist and asking your healthcare provider any questions you may have about Dalfampridine or its use.

Always follow your healthcare provider’s instructions and recommendations regarding the use, storage, and disposal of Dalfampridine, and contact them with any concerns or questions you may have.