WARNING

Korlym is a medication that contains the active ingredient mifepristone. It is primarily used for the treatment of a hormonal disorder called Cushing’s syndrome, which is characterized by excessive levels of the hormone cortisol in the body. While Korlym can be effective in managing this condition, it is important to be aware of the potential risks associated with its use. Here are some key risks of taking Korlym:

• Adrenal insufficiency: Korlym can cause a reduction in cortisol levels, which may lead to adrenal insufficiency. This condition occurs when the adrenal glands do not produce enough cortisol, resulting in symptoms such as fatigue, weakness, low blood pressure, and nausea.
• Low blood potassium levels: Korlym can cause a decrease in blood potassium levels (hypokalemia), which can lead to muscle weakness, abnormal heart rhythms, and in severe cases, life-threatening complications.
• Vaginal bleeding: Women who are pregnant or of childbearing potential should be aware that Korlym can cause vaginal bleeding or even induce abortion. It is important to use effective contraception while taking this medication.
• Drug interactions: Korlym can interact with certain medications, such as antifungal drugs, anticoagulants, and certain seizure medications. These interactions can affect the effectiveness or safety of both Korlym and the other drugs.
• Potential liver problems: There have been reports of liver-related adverse effects in individuals taking Korlym, including elevated liver enzyme levels, liver damage, and hepatitis. Regular monitoring of liver function is typically recommended.
• Other side effects: Common side effects of Korlym may include nausea, vomiting, dizziness, headache, and fatigue. These side effects are usually mild, but it is important to discuss any persistent or concerning symptoms with a healthcare professional.

It is crucial to remember that this is just a brief overview of the risks associated with Korlym. If you are considering taking this medication, it is essential to consult with a healthcare professional who can provide detailed information tailored to your specific situation, assess the potential benefits and risks, and monitor your health throughout the treatment.

Why is this medication prescribed?

Korlym is primarily prescribed for the treatment of a hormonal disorder called Cushing’s syndrome. Cushing’s syndrome is characterized by the excessive production of the hormone cortisol by the adrenal glands. This condition can be caused by various factors, including a benign tumor in the pituitary gland (called Cushing’s disease), adrenal gland tumors, or the use of corticosteroid medications.

Korlym, which contains the active ingredient mifepristone, is a medication that works by blocking the receptors for cortisol in the body. By doing so, it helps to reduce the effects of excessive cortisol and manage the symptoms associated with Cushing’s syndrome. These symptoms may include weight gain, high blood pressure, muscle weakness, fatigue, skin changes, and mood disturbances.

How should this medicine be used?

The use of Korlym should be strictly supervised by a healthcare professional who is knowledgeable about the medication and its appropriate dosing. It is crucial to follow the prescribed instructions and guidelines for its use. Here are some general considerations for using Korlym:

• Dosage: The dosage of Korlym can vary depending on the specific condition being treated, individual factors, and the healthcare provider’s recommendations. The healthcare professional will determine the appropriate starting dose and may adjust it based on the patient’s response and any potential side effects.
• Administration: Korlym is available in oral tablet form. It should be taken with a glass of water, usually once daily. The exact timing and instructions for taking Korlym may vary, so it’s important to carefully follow the healthcare provider’s guidance.
• Food and drug interactions: Korlym should be taken with a meal or within 30 minutes of eating food. This is because taking Korlym on an empty stomach may decrease its effectiveness. It’s also important to inform the healthcare professional about any other medications, supplements, or herbal products being taken, as they may interact with Korlym and affect its efficacy or safety.
• Pregnancy precautions: Korlym is contraindicated during pregnancy as it may cause harm to the developing fetus. Adequate contraception should be used by women of childbearing potential during treatment with Korlym, and pregnancy tests may be performed before starting the medication and as needed during treatment.
• Regular monitoring: During treatment with Korlym, the healthcare professional may regularly monitor the patient’s hormone levels, liver function, blood potassium levels, and overall response to the medication. Regular check-ups and laboratory tests are important for assessing the effectiveness and safety of Korlym.

It is crucial to consult with a healthcare professional for specific instructions on how to use Korlym. They will consider the individual’s medical history, current condition, and other relevant factors to provide personalized guidance on the appropriate use of the medication.

Other uses for this medicine

Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that is primarily used for the short-term relief of moderate to severe pain. However, there are some other uses for Ketorolac as well, including:

• Treatment of postoperative inflammation: Ketorolac can be used to manage pain and reduce inflammation after surgical procedures.
• Migraine headaches: It can be employed as a short-term treatment option for migraines, particularly when other medications are not effective.
• Renal colic: Ketorolac may be used in the management of renal colic, which is severe pain caused by kidney stones.

What special precautions should I follow?

Regarding special precautions for Korlym, here are some important considerations:

• Pregnancy: Korlym is contraindicated during pregnancy due to the risk of fetal harm. It should not be used if a woman is already pregnant or plans to become pregnant while taking the medication.
• Contraception: Effective contraception should be used by women of childbearing potential during treatment with Korlym. It is important to discuss and use appropriate contraceptive methods under the guidance of a healthcare professional.
• Liver function: Korlym may affect liver function, so regular monitoring of liver enzyme levels is typically recommended. Individuals with pre-existing liver conditions or abnormalities may require additional caution and monitoring.
• Adrenal insufficiency: Korlym can cause a reduction in cortisol levels, which may lead to adrenal insufficiency. Healthcare professionals will monitor adrenal function and may need to adjust the medication or provide additional supportive care if adrenal insufficiency occurs.
• Drug interactions: Korlym can interact with certain medications, including antifungal drugs, anticoagulants, and certain seizure medications. Informing the healthcare professional about all medications being taken is essential to avoid potential interactions.
• Adverse reactions: Korlym may cause side effects such as nausea, vomiting, dizziness, fatigue, and headache. Any persistent or concerning symptoms should be reported to a healthcare professional.

It’s important to consult with a healthcare professional for specific precautions and considerations based on an individual’s medical history, current medications, and overall health condition. They can provide personalized guidance regarding the use of Korlym and monitor for any potential risks or complications.

What special dietary instructions should I follow?

When taking Korlym, there are some general dietary instructions to follow:

• Food intake: Korlym should be taken with a meal or within 30 minutes of eating food. This is because taking Korlym on an empty stomach may decrease its effectiveness. It is recommended to have a meal or snack before taking the medication.
• Grapefruit and grapefruit juice: Avoid consuming grapefruit or grapefruit juice while taking Korlym. Grapefruit can interfere with the metabolism of the medication and may affect its effectiveness.

What should I do if I forget a dose?

If you forget to take a dose of Korlym, here are some general guidelines:

• Timing: Take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not double dose: Do not take a double dose to make up for the missed one. Taking more than the prescribed amount can increase the risk of side effects.
• Consult healthcare professional: If you are unsure about what to do or if you have missed multiple doses, it is recommended to contact your healthcare professional for guidance.

What side effects can this medication cause?

Korlym (mifepristone) can cause several side effects. It’s important to note that not all individuals will experience these side effects, and the severity and frequency of side effects may vary. If you are prescribed Korlym, it is important to discuss potential side effects with your healthcare professional. Here are some common side effects associated with Korlym:

• Nausea and vomiting: These gastrointestinal symptoms are among the most commonly reported side effects of Korlym. Taking the medication with food or a snack can help minimize these effects.
• Fatigue: Feelings of tiredness, weakness, or fatigue may occur while taking Korlym.
• Headache: Some individuals may experience headaches as a side effect of Korlym.
• Dizziness: Korlym can cause dizziness or lightheadedness in some individuals.
• Menstrual changes: Women may experience changes in their menstrual cycle, such as irregular periods or changes in menstrual flow.
• Hypokalemia: Korlym can cause low levels of potassium in the blood (hypokalemia). This can result in symptoms such as muscle weakness, abnormal heart rhythms, and fatigue.
• Adrenal insufficiency: Korlym’s action of blocking cortisol receptors can lead to a reduction in cortisol levels, potentially causing adrenal insufficiency. Symptoms of adrenal insufficiency may include fatigue, weakness, low blood pressure, and nausea.
• Elevated liver enzymes: Korlym may cause an increase in liver enzyme levels, indicating possible liver problems. Regular monitoring of liver function is typically recommended during treatment.
• Vaginal bleeding: Women who are pregnant or of childbearing potential should be aware that Korlym can cause vaginal bleeding or even induce abortion.
• Mood changes: Some individuals may experience mood swings, anxiety, or depressive symptoms while taking Korlym.

These are not all the possible side effects of Korlym. It is important to consult with your healthcare professional for a comprehensive list of potential side effects and to discuss any concerns you may have. If you experience severe or persistent side effects, it is important to seek medical attention.

What should I know about storage and disposal of this medication?

Storage:

• Store Korlym according to the instructions provided by the manufacturer or as directed by your healthcare professional.
• Typically, Korlym should be stored at room temperature, away from moisture, heat, and direct light.
• Store Korlym in a secure location, out of the reach of children and pets.

Disposal:

• Dispose of Korlym in accordance with local regulations and guidelines for the safe disposal of medications.
• Do not dispose of Korlym by flushing it down the toilet or pouring it down the drain, as it can contaminate water sources.
• If you are unsure about how to dispose of Korlym, consult your healthcare professional or pharmacist. They can provide guidance on the appropriate disposal methods in your area.

In case of emergency/overdose

In case of an emergency or overdose involving Korlym, it is important to take the following steps:

• Seek immediate medical attention: If you or someone else may have taken too much Korlym or is experiencing severe symptoms, call emergency services or go to the nearest emergency room.
• Provide information: Inform the healthcare professionals about the medication involved (Korlym) and the amount taken, if known.
• Do not induce vomiting: Unless specifically instructed by healthcare professionals, do not induce vomiting unless directed to do so.
• Follow medical advice: Follow any medical advice or instructions given by healthcare professionals to manage the situation appropriately.

What other information should I know?

• Regular check-ups: Regularly visit your healthcare professional for follow-up appointments and monitoring while taking Korlym. They will assess your progress, monitor for any potential side effects, and adjust the treatment plan if necessary.
• Medication interactions: Inform your healthcare professional about all other medications, supplements, or herbal products you are taking. Certain medications may interact with Korlym and affect its effectiveness or increase the risk of side effects.
• Compliance: It is important to take Korlym as prescribed by your healthcare professional. Do not alter the dosage or stop the medication without consulting your healthcare professional.
• Patient education: Make sure you understand the potential benefits and risks of taking Korlym. If you have any questions or concerns, discuss them with your healthcare professional.

Always follow the advice and instructions provided by your healthcare professional regarding the storage, disposal, and management of Korlym to ensure safe and appropriate use of the medication.