Why is this medication prescribed?

Kepivance (palifermin) is prescribed to prevent or treat severe mouth sores (oral mucositis) in patients who are undergoing high-dose chemotherapy and radiation therapy followed by a stem cell transplant. It is specifically indicated for use in patients with hematologic malignancies (cancers affecting the blood and bone marrow) such as leukemia and lymphoma.

Chemotherapy and radiation therapy can damage the lining of the mouth, leading to painful mouth sores. These sores can make it difficult to eat, drink, and speak, and they can increase the risk of infections. Kepivance is a recombinant human keratinocyte growth factor (KGF) that helps stimulate the growth of cells lining the mouth, throat, and gastrointestinal tract. By promoting the growth and repair of these tissues, Kepivance can help reduce the severity and duration of mouth sores caused by cancer treatment.

How should this medicine be used?

Kepivance (palifermin) is typically administered as an injection and should be used under the supervision of a healthcare professional experienced in cancer treatment. The dosage and treatment schedule may vary depending on the specific situation, so it’s important to follow the instructions provided by your doctor. Here are some general guidelines:

• Administration: Kepivance is given as an intravenous (IV) infusion, meaning it is injected directly into a vein. It should be administered by a healthcare professional.
• Timing: Kepivance is usually given in three doses, with each dose given on three consecutive days before and after the stem cell transplant procedure. The first dose is typically administered three days before the start of conditioning chemotherapy, and the remaining two doses are given on the two days leading up to the transplant.
• Dosage: The specific dosage of Kepivance will be determined by your doctor based on your body weight and other factors. It is important to follow the prescribed dosage carefully.
• Precautions: Kepivance is not recommended for use in patients with known hypersensitivity to palifermin or any of its components. Inform your healthcare provider about any allergies or medical conditions you have before starting treatment.
• Other medications: It’s important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and any herbal supplements, as they may interact with Kepivance.

Remember, these are general guidelines, and the specific instructions for using Kepivance may vary for each individual. It’s crucial to consult with your healthcare professional or refer to the medication’s package insert for precise dosage instructions and any additional precautions.

Other uses for this medicine

Kepivance (palifermin) is primarily used for the prevention and treatment of severe mouth sores (oral mucositis) in patients undergoing high-dose chemotherapy and radiation therapy followed by a stem cell transplant. However, it’s important to note that the approved uses of medications can change over time, and there may be new indications for Kepivance that have emerged since then. It’s always best to consult with a healthcare professional or refer to the latest medical resources for the most up-to-date information on its uses.

What special precautions should I follow?

Regarding special precautions for Kepivance, here are some important points to consider:

• Hypersensitivity: Kepivance should not be used in individuals with known hypersensitivity to palifermin or any of its components. Allergic reactions, including severe allergic reactions, can occur. If you experience signs of an allergic reaction such as difficulty breathing, rash, itching, or swelling, seek immediate medical attention.
• Tumorigenic potential: The long-term effects of Kepivance on the development of tumors are not fully understood. It should only be used when the potential benefits outweigh the potential risks, especially in patients with a history of cancer.
• Potential for fluid overload: Kepivance infusion may result in fluid overload. This is particularly important in patients with pre-existing fluid retention, heart failure, or other medical conditions that can be exacerbated by excess fluid.
• Monitoring: During treatment with Kepivance, your healthcare provider will monitor your condition closely to assess the response and manage any potential side effects. Regular monitoring of blood counts and other laboratory parameters may be required.
• Drug interactions: Inform your healthcare provider about all the medications you are taking, as certain drugs may interact with Kepivance. It’s important to disclose any prescription medications, over-the-counter drugs, or herbal supplements you are using.

These are general precautions associated with Kepivance, but it’s crucial to consult with your healthcare professional or refer to the medication’s package insert for a comprehensive list of precautions and potential side effects based on your specific situation.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Kepivance (palifermin). However, it’s always a good idea to follow a healthy and balanced diet during cancer treatment to support your overall well-being. Your healthcare provider or a registered dietitian can provide personalized dietary recommendations based on your specific needs and treatment plan.

What should I do if I forget a dose?

Regarding a missed dose of Kepivance, it’s important to consult with your healthcare provider for guidance. They will be able to provide specific instructions based on your treatment schedule and the reason for the missed dose. In general, it’s advisable to adhere to the prescribed dosing schedule as closely as possible to ensure optimal effectiveness of the medication. It’s not recommended to take a double dose to make up for a missed one unless instructed by your healthcare provider.

What side effects can this medication cause?

Kepivance (palifermin) may cause side effects in some individuals. Here are some of the potential side effects associated with its use:

• Skin-related side effects: Palifermin may cause rash, redness, itching, or other skin reactions at the injection site. These side effects are usually mild and temporary.
• Mouth and throat discomfort: Although Kepivance is primarily used to prevent or treat mouth sores, it can cause temporary mouth and throat discomfort, such as a metallic taste, soreness, or irritation.
• Swelling: Some individuals may experience swelling, particularly in the hands, feet, or face, as a result of fluid retention. It’s important to inform your healthcare provider if you notice any sudden or severe swelling.
• Allergic reactions: While uncommon, allergic reactions to Kepivance can occur. Signs of an allergic reaction may include difficulty breathing, hives, swelling of the face or throat, or a rash. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Other side effects: Additional side effects that have been reported with the use of Kepivance include headache, muscle aches, joint pain, fatigue, and changes in taste sensation.

It’s important to remember that not everyone will experience these side effects, and the severity and frequency of side effects can vary from person to person. If you experience any persistent or concerning side effects while taking Kepivance, it is crucial to consult your healthcare provider for further evaluation and guidance.

This is not an exhaustive list of potential side effects, and there may be other uncommon or rare side effects associated with Kepivance. It’s always recommended to consult with a healthcare professional or refer to the medication’s package insert for comprehensive and up-to-date information on side effects.

What should I know about storage and disposal of this medication?

• Storage: Kepivance should be stored in the refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze the medication. Protect the vials from light by keeping them in the original carton until ready to use. Do not use Kepivance if it has been frozen or if it has expired.
• Disposal: Properly dispose of any unused or expired Kepivance vials. It is recommended to follow local regulations or consult with a pharmacist or healthcare professional for guidance on safe disposal methods. Do not dispose of medication in household trash or flush it down the toilet unless instructed to do so.

In case of emergency/overdose

In case of emergency or overdose, it’s important to seek immediate medical attention. Contact your local emergency services or go to the nearest emergency room. It may be helpful to bring the medication packaging or any remaining vials with you to provide information to the healthcare professionals.

What other information should I know?

• Keep all appointments: It’s important to attend all scheduled appointments with your healthcare provider for proper monitoring of your condition and response to Kepivance treatment.
• Inform healthcare providers: Make sure to inform all healthcare providers involved in your care, including doctors, dentists, and nurses, about your use of Kepivance. This includes disclosing any other medications or supplements you are taking.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it’s important to discuss the potential risks and benefits of using Kepivance with your healthcare provider. The effects of Kepivance on pregnancy and breastfeeding are not well-studied.
• Other medical conditions: Inform your healthcare provider about any other medical conditions you have, such as kidney or liver problems, as they may affect the use of Kepivance.

As always, it’s crucial to consult with your healthcare provider or refer to the medication’s package insert for comprehensive and up-to-date information specific to your situation. They can provide you with personalized advice and address any concerns you may have.