WARNING

While Jynarque (tolvaptan) can be an effective treatment for autosomal dominant polycystic kidney disease (ADPKD), it is important to be aware of the potential risks associated with its use. Here is a brief overview of some of the risks:

• Liver Injury: Jynarque has been associated with liver injury, including cases of serious liver damage. It is important to monitor liver function through regular blood tests during treatment. If signs of liver injury occur, such as yellowing of the skin or eyes, dark urine, abdominal pain, or persistent nausea, it is crucial to seek medical attention immediately.
• Increased Urine Output and Dehydration: Jynarque is a diuretic, which means it increases urine production. This can lead to dehydration if fluid intake is not adequately maintained. It is important to drink enough fluids while taking Jynarque and to promptly report any symptoms of dehydration, such as excessive thirst, dry mouth, decreased urine output, or dizziness.
• Electrolyte Imbalance: Diuretic effects of Jynarque can lead to imbalances in electrolytes, such as sodium and potassium. Regular monitoring of electrolyte levels is necessary, especially in individuals with a history of electrolyte abnormalities or those taking other medications that can affect electrolyte balance.
• Rapid Onset of Excessive Thirst and Polyuria: Some individuals may experience a rapid onset of excessive thirst and increased urination shortly after starting Jynarque. This can be a sign of water and electrolyte imbalance. It is important to inform your healthcare provider if these symptoms occur.
• Adverse Effects on Pregnancy: Jynarque is associated with a risk of harm to the developing fetus. It should not be used during pregnancy, and effective contraception should be used by both men and women during Jynarque treatment.
• Other Adverse Reactions: Jynarque may cause other side effects, including headache, dizziness, diarrhea, nausea, and increased liver enzymes. It is important to discuss any concerning symptoms with your healthcare provider.

It is essential to have open and regular communication with your healthcare provider throughout Jynarque treatment. They can provide detailed information about the potential risks and benefits of the medication based on your individual health profile and help monitor and manage any potential side effects that may arise.

Why is this medication prescribed?

Jynarque is a medication prescribed for the treatment of autosomal dominant polycystic kidney disease (ADPKD) in adults. ADPKD is a genetic disorder characterized by the growth of numerous cysts in the kidneys, leading to their enlargement and potential loss of function over time. Jynarque contains the active ingredient tolvaptan, which is a selective vasopressin V2-receptor antagonist.

Jynarque works by blocking the effects of a hormone called vasopressin, which is involved in fluid regulation in the body. By inhibiting the action of vasopressin, Jynarque helps to reduce the production and growth of cysts in the kidneys, slowing down the progression of ADPKD.

The goals of Jynarque treatment in ADPKD include reducing the rate of kidney enlargement, preserving kidney function, and delaying the need for kidney replacement therapies such as dialysis or kidney transplantation. It is important to note that Jynarque is not a cure for ADPKD, but rather a treatment aimed at slowing down the progression of the disease.

How should this medicine be used?

As for how Jynarque should be used, it is important to follow the instructions provided by your healthcare provider. Generally, Jynarque is taken orally as tablets and should be taken with water. The dosage and treatment duration will be determined by your healthcare provider based on your individual circumstances.

Typically, the initial dosage of Jynarque is 60 mg once daily, which may be increased to 90 mg once daily after the first week of treatment if tolerated. The dosage adjustment and titration will be determined by your healthcare provider based on your response to the medication and any side effects experienced.

Jynarque should be taken consistently and at the same time each day. It is recommended to take it without food, at least 1 hour before or 2 hours after a meal. It is important not to crush, chew, or break the tablets, as they should be swallowed whole.

During Jynarque treatment, your healthcare provider will closely monitor your kidney function, fluid balance, and liver enzymes through regular check-ups and laboratory tests. They will also assess the benefits and risks of continuing Jynarque therapy based on your individual response and any potential side effects.

It is important to have regular discussions with your healthcare provider regarding the use of Jynarque, any concerns or questions you may have, and to report any new symptoms or changes in your health. They can provide you with detailed instructions and guidance specific to your situation.

Other uses for this medicine

Jynarque (generic name: tolvaptan) is a medication primarily used for the treatment of autosomal dominant polycystic kidney disease (ADPKD). However, it may also have other uses as determined by your healthcare provider. It is always important to follow your healthcare provider’s instructions regarding the use of any medication.

What special precautions should I follow?

Regarding special precautions for Jynarque, here are some general guidelines:

• Follow the prescribed dosage: Take Jynarque exactly as prescribed by your healthcare provider. Do not change the dose or stop taking it without consulting your doctor.
• Take it with food: Jynarque should be taken with food, preferably in the morning and in the evening.
• Stay hydrated: It is important to maintain good hydration while taking Jynarque. Drink enough fluids throughout the day unless otherwise directed by your doctor.
• Regular monitoring: Your healthcare provider may monitor your liver function and levels of electrolytes, such as sodium, during your treatment with Jynarque. Attend all scheduled appointments and follow any recommended monitoring procedures.
• Be aware of potential side effects: Jynarque can cause side effects such as excessive thirst, increased urination, dry mouth, and weakness. If you experience any severe or persistent side effects, notify your doctor.
• Inform your doctor about other medications: Make sure your healthcare provider is aware of all the medications, supplements, or herbal products you are taking, as Jynarque may interact with certain substances.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of taking Jynarque with your healthcare provider. This medication may not be suitable during pregnancy or lactation.

Remember, these are general precautions, and it’s important to consult with your healthcare provider or pharmacist for personalized advice and specific precautions based on your individual medical history and condition.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Fluid Intake: Your healthcare provider may recommend specific guidelines for fluid intake while taking Jynarque. It is important to follow these instructions carefully, as excessive fluid intake can increase the risk of side effects.
• Salt Intake: Maintaining an appropriate salt intake may also be important. Again, your healthcare provider can provide you with specific recommendations tailored to your individual needs.

What should I do if I forget a dose?

• If you miss a dose of Jynarque, it is important to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do not double the dose to make up for a missed one, as taking more than the prescribed amount may increase the risk of side effects.

What side effects can this medication cause?

Jynarque (generic name: tolvaptan) is a medication used to treat autosomal dominant polycystic kidney disease (ADPKD) in adults. While it can be effective in managing the condition, like any medication, it may also cause side effects. Common side effects of Jynarque can include:

• Thirst and increased urination: Jynarque is a diuretic, which means it increases urine production. This can lead to increased thirst and more frequent urination.
• Dry mouth: Some individuals may experience a dry or parched feeling in their mouth.
• Polyuria: Jynarque may cause excessive urine production, leading to increased frequency of urination.
• Increased uric acid levels: Jynarque can elevate the levels of uric acid in the blood, which may increase the risk of gout attacks or kidney stone formation in susceptible individuals.
• Elevated liver enzymes: Some individuals taking Jynarque may experience an increase in liver enzyme levels. Regular monitoring of liver function is typically recommended.
• Hypovolemia: Jynarque can lead to reduced blood volume, which may cause symptoms such as dizziness, lightheadedness, or low blood pressure.
• Increased sodium levels: This medication can raise the levels of sodium in the blood, potentially leading to symptoms such as thirst, confusion, seizures, or muscle twitching.
• Electrolyte imbalances: Jynarque may cause disturbances in electrolyte levels, including decreases in potassium, magnesium, and chloride. These imbalances can result in symptoms such as muscle weakness, irregular heart rhythms, or fatigue.
• Increased risk of liver injury: In rare cases, Jynarque may cause serious liver injury, which can manifest as jaundice (yellowing of the skin and eyes), abdominal pain, dark urine, or unusual tiredness. Immediate medical attention is necessary if these symptoms occur.

It’s important to note that this is not an exhaustive list of all possible side effects. Different individuals may experience varying side effects, and some may not experience any at all. If you are taking Jynarque and are concerned about its side effects, it is recommended to consult with your healthcare provider for personalized information and guidance.

What should I know about storage and disposal of this medication?

1. Storage:
   • Follow the storage instructions provided by your pharmacist or healthcare provider.
   • Typically, Jynarque should be stored at room temperature, away from excessive heat, moisture, and direct light.
   • Keep it out of reach of children and pets.
2. Disposal:
   • Discard any unused or expired medication properly.
   • Check with your pharmacist or local waste disposal facility to learn about the recommended methods for medication disposal. This helps to prevent accidental ingestion or environmental contamination.

In case of emergency/overdose

• In case of an emergency or suspected overdose, immediately contact your local emergency services or go to the nearest emergency room.
• It is helpful to have the medication bottle or packaging available for healthcare professionals to easily identify the medication involved.

What other information should I know?

• Attend regular follow-up appointments with your healthcare provider to monitor your progress and make any necessary adjustments to your treatment plan.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking to avoid potential interactions.
• Be aware of the potential side effects associated with Jynarque and report any unusual or severe symptoms to your healthcare provider promptly.
• If you have any questions or concerns regarding your medication or treatment, consult with your healthcare provider or pharmacist for clarification.

As always, it’s important to consult your healthcare provider or pharmacist for personalized instructions and information regarding the storage, disposal, emergency procedures, and any other specific considerations related to your Jynarque medication.