WARNING

Invokamet is a medication that combines two active ingredients: canagliflozin and metformin. It is primarily used to treat type 2 diabetes. While Invokamet can be beneficial for managing blood sugar levels, like any medication, it comes with potential risks and side effects. Here are some of the risks associated with taking Invokamet:

• Hypoglycemia: Invokamet can lower blood sugar levels, and in some cases, it may lead to hypoglycemia or low blood sugar. Symptoms of hypoglycemia include dizziness, weakness, confusion, sweating, and in severe cases, it can cause unconsciousness or seizures.
• Urinary Tract Infections: Canagliflozin, one of the components of Invokamet, works by increasing the amount of sugar excreted through urine. This can create an environment that is more conducive to the growth of bacteria, leading to an increased risk of urinary tract infections.
• Genital Yeast Infections: Similarly, due to increased sugar in the urine, some individuals taking Invokamet may experience an increased risk of genital yeast infections. Symptoms may include itching, redness, soreness, and discharge.
• Dehydration and Electrolyte Imbalance: Canagliflozin can cause increased urination, which may result in dehydration and electrolyte imbalances. It is important to stay adequately hydrated while taking Invokamet and be aware of the signs of dehydration, such as dry mouth, increased thirst, dizziness, and fatigue.
• Kidney Problems: Invokamet can affect kidney function, particularly in individuals with pre-existing kidney disease. It is crucial to monitor kidney function regularly while taking this medication.
• Bone Fractures: Some studies have suggested that canagliflozin may be associated with an increased risk of bone fractures, particularly in older individuals. The exact relationship between Invokamet and bone fractures is still being studied, and more research is needed to understand this potential risk better.

It is important to note that these risks may vary from person to person, and not everyone will experience them. It is crucial to discuss the potential risks and benefits of Invokamet with a healthcare professional before starting the medication, as they can provide personalized advice based on your specific medical history and circumstances.

Why is this medication prescribed?

Invokamet is prescribed primarily for the management of type 2 diabetes. It is a combination medication that contains two active ingredients: canagliflozin and metformin.

• Canagliflozin: This is a medication from the class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. Canagliflozin works by inhibiting the reabsorption of glucose in the kidneys, leading to increased glucose excretion through urine. By reducing the amount of glucose in the bloodstream, canagliflozin helps to lower blood sugar levels.
• Metformin: Metformin is a widely used medication for the treatment of type 2 diabetes. It works by reducing the production of glucose by the liver and improving the body’s sensitivity to insulin, thus aiding in the effective use of insulin to regulate blood sugar levels.

When used in combination, canagliflozin and metformin in Invokamet can provide complementary effects in managing blood sugar levels in people with type 2 diabetes. By increasing glucose excretion through urine and improving insulin sensitivity, Invokamet helps to lower and control blood sugar levels.

How should this medicine be used?

The usage instructions for Invokamet should be followed as prescribed by your healthcare professional. However, it is important to note that the following guidelines provide a general overview and should not replace specific instructions from your healthcare provider.

• Dosage: Invokamet is available in different strengths, and the appropriate dosage will be determined by your doctor based on your individual needs and response to treatment. The dosage may also depend on other factors such as your kidney function.
• Administration: Invokamet is usually taken orally with a glass of water. It can be taken with or without food. It is important to follow the specific instructions provided by your doctor or on the medication label.
• Regular use: Invokamet is typically taken once or twice a day, depending on the prescribed dosage. It is important to take the medication consistently at the same time(s) each day to maintain stable blood sugar control.
• Monitoring: Regular monitoring of blood sugar levels is essential while taking Invokamet. This allows you and your healthcare provider to assess the effectiveness of the medication and make any necessary adjustments to the dosage or treatment plan.
• Complementary lifestyle changes: Invokamet is most effective when used as part of a comprehensive treatment plan that includes healthy lifestyle changes. This may include following a balanced diet, engaging in regular physical activity, and maintaining a healthy weight. It is important to discuss any lifestyle changes with your healthcare provider to ensure they are appropriate for your individual situation.
• Safety precautions: It is important to follow the safety precautions outlined by your healthcare provider while taking Invokamet. This may include avoiding excessive alcohol consumption, as it can increase the risk of certain side effects. It is also essential to inform your doctor about any other medications or supplements you are taking to prevent potential interactions.

Always consult your healthcare professional for specific instructions and guidance on how to use Invokamet properly. They will consider your unique medical condition and make recommendations tailored to your needs.

Other uses for this medicine

Invokamet is primarily prescribed for the management of type 2 diabetes. However, it is important to note that medications are typically prescribed for specific approved uses, and using them for other purposes without medical supervision is not recommended. Therefore, the off-label use of Invokamet should be discussed with a healthcare professional to assess the potential risks and benefits in specific situations.

What special precautions should I follow?

As for special precautions associated with Invokamet, here are some important considerations:

• Kidney function: Invokamet can affect kidney function, and it may not be suitable for individuals with certain kidney conditions or impaired renal function. Your healthcare provider may assess your kidney function before starting Invokamet and periodically monitor it during treatment.
• Dehydration: Invokamet can increase the risk of dehydration due to its diuretic effect (increased urination). It is important to maintain adequate hydration by drinking sufficient fluids, especially during hot weather or when engaging in activities that can lead to fluid loss.
• Hypoglycemia: While Invokamet is not typically associated with an increased risk of hypoglycemia when used as a monotherapy, it can still cause low blood sugar levels when used in combination with other diabetes medications or insulin. It is essential to be aware of the signs and symptoms of hypoglycemia and regularly monitor blood sugar levels.
• Infections: Invokamet, particularly the canagliflozin component, may increase the risk of urinary tract infections and genital yeast infections. If you experience symptoms such as frequent urination, pain or burning during urination, genital itching, or unusual discharge, it is important to consult your healthcare provider.
• Medication interactions: Inform your healthcare provider about all the medications, supplements, or herbal products you are taking, as they may interact with Invokamet. Certain medications, such as diuretics and medications that affect kidney function, may increase the risk of side effects when taken concurrently with Invokamet.
• Surgery and procedures: If you are scheduled for surgery or any medical procedure, inform the healthcare professionals involved that you are taking Invokamet. Your doctor may provide specific instructions regarding medication management during those times.

It is crucial to follow your healthcare provider’s instructions, attend regular check-ups, and communicate any concerns or potential side effects while taking Invokamet. They can provide personalized guidance and ensure the medication is used safely and effectively in your specific situation.

What special dietary instructions should I follow?

When taking Invokamet, it is important to follow any dietary instructions provided by your healthcare provider. Here are some general dietary guidelines to consider:

• Balanced diet: Maintain a balanced and healthy diet that is rich in fruits, vegetables, whole grains, and lean proteins. Limit the consumption of processed foods, sugary beverages, and foods high in saturated and trans fats.
• Carbohydrate intake: Invokamet works by helping to lower blood sugar levels, particularly by reducing the reabsorption of glucose in the kidneys. It is important to monitor your carbohydrate intake and distribute it throughout the day to help manage blood sugar levels effectively.
• Alcohol consumption: Alcohol can affect blood sugar levels and increase the risk of side effects associated with Invokamet, such as hypoglycemia (low blood sugar) and dehydration. It is advisable to moderate or avoid alcohol consumption while taking Invokamet. Discuss any specific alcohol-related concerns with your healthcare provider.
• Hydration: Invokamet has a diuretic effect, which can increase urine output. Ensure that you stay adequately hydrated by drinking sufficient fluids throughout the day, especially during hot weather or when engaging in physical activity.

What should I do if I forget a dose?

If you forget to take a dose of Invokamet, follow these general guidelines:

• Timing: If you remember within a few hours of the missed dose, take the medication as soon as possible. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not double dose: Do not take a double dose to make up for the missed one. Taking more than the prescribed dose can increase the risk of side effects.
• Consult your healthcare provider: If you are unsure about what to do or if you have missed multiple doses, it is best to consult your healthcare provider for guidance. They can provide specific recommendations based on your individual circumstances.

What side effects can this medication cause?

Invokamet is a combination medication that contains two active ingredients: canagliflozin and metformin. It is primarily used for the treatment of type 2 diabetes. While Invokamet can be effective in managing blood sugar levels, like any medication, it can potentially cause side effects. Here are some of the possible side effects associated with Invokamet:

• Hypoglycemia: Invokamet can lower blood sugar levels, and in some cases, this can lead to hypoglycemia (low blood sugar). Symptoms may include dizziness, shakiness, confusion, weakness, headache, and excessive sweating.
• Urinary tract infections: Canagliflozin, one of the active ingredients in Invokamet, is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. This class of medications increases the risk of urinary tract infections (UTIs) due to increased glucose in the urine.
• Increased urination: Canagliflozin, being an SGLT2 inhibitor, works by increasing the excretion of glucose in the urine. This can result in increased urination.
• Genital yeast infections: Increased glucose levels in the urine can create a favorable environment for the growth of yeast, potentially leading to genital yeast infections, particularly in women.
• Increased thirst: Canagliflozin’s mechanism of action can cause increased thirst, as it leads to more glucose being excreted in the urine.
• Gastrointestinal effects: Common gastrointestinal side effects of Invokamet may include nausea, vomiting, diarrhea, and abdominal pain.
• Hypotension: Canagliflozin can cause a slight decrease in blood pressure, which may result in symptoms like dizziness or lightheadedness.
• Lactic acidosis (rare): Metformin, the other active ingredient in Invokamet, has a rare but serious side effect called lactic acidosis. This condition is characterized by an accumulation of lactic acid in the body and may cause symptoms such as weakness, muscle pain, difficulty breathing, and abdominal discomfort.

It’s important to note that not everyone will experience these side effects, and some people may experience different or no side effects at all. If you are taking Invokamet and are concerned about potential side effects, it’s best to consult with your healthcare provider, who can provide personalized information and guidance based on your specific health situation.

What should I know about storage and disposal of this medication?

Storage and disposal: Here are some important points regarding the storage and disposal of Invokamet:

• Storage: Store Invokamet at room temperature, away from moisture, heat, and direct light. Follow the specific storage instructions provided by the manufacturer or on the medication label.
• Keep out of reach of children and pets: Store Invokamet in a secure location, out of the reach of children and pets, to prevent accidental ingestion.
• Do not use expired medication: Check the expiration date on the medication packaging and do not use Invokamet if it has expired. Properly dispose of expired medication as outlined below.
• Disposal: Dispose of unused or expired Invokamet properly according to local regulations or guidelines. Do not flush medication down the toilet or pour it down the drain unless specifically instructed to do so. Consult with your pharmacist or local waste disposal authority for proper disposal methods.

In case of emergency/overdose

• Emergency assistance: In the event of a medical emergency or suspected overdose, immediately contact emergency services or your local poison control center for assistance.
• Symptoms of overdose: Symptoms of an Invokamet overdose may include severe hypoglycemia (low blood sugar), dizziness, confusion, seizures, or other serious side effects. It is important to seek immediate medical attention if an overdose is suspected.

What other information should I know?

• Regular medical check-ups: Regularly visit your healthcare provider for check-ups and monitoring of your diabetes management. They can assess the effectiveness of Invokamet and make any necessary adjustments to your treatment plan.
• Blood sugar monitoring: Follow your healthcare provider’s instructions for monitoring your blood sugar levels regularly. This will help you track your response to Invokamet and ensure optimal diabetes management.
• Medication interactions: Inform your healthcare provider about all medications, supplements, or herbal products you are taking to avoid potential interactions with Invokamet. Certain medications may affect the effectiveness or safety of Invokamet, and your healthcare provider can provide guidance on any necessary adjustments.
• Medical procedures: If you are scheduled for surgery or any medical procedure, inform the healthcare professionals involved about your use of Invokamet. Your doctor may provide specific instructions regarding medication management during those times.

It is essential to follow your healthcare provider’s instructions and seek their guidance for any specific information or concerns related to your individual situation while taking Invokamet.