Why is this medication prescribed?

Injectafer (ferric carboxymaltose) is a prescription medication primarily used to treat iron deficiency anemia in adults who have intolerance or inadequate response to oral iron supplementation. Iron deficiency anemia occurs when the body does not have enough iron to produce sufficient red blood cells, leading to symptoms such as fatigue, weakness, and shortness of breath.

Injectafer is administered intravenously, typically as a series of two doses separated by at least seven days. It delivers iron directly into the bloodstream, bypassing the need for absorption through the gastrointestinal tract, which can be problematic for individuals with absorption issues or those who cannot tolerate oral iron supplements.

It is important to note that Injectafer is typically prescribed when oral iron supplements have been ineffective or not well-tolerated. Oral iron supplementation is usually the first-line treatment for iron deficiency anemia. However, some individuals may experience side effects from oral iron, such as gastrointestinal disturbances or poor absorption due to certain medical conditions.

How should this medicine be used?

Here is a general overview of how Injectafer is typically used:

• Medical Evaluation: Before initiating treatment with Injectafer, your healthcare provider will assess your medical history, perform a physical examination, and order relevant laboratory tests to confirm the diagnosis of iron deficiency anemia.
• Dosage Determination: The dosage of Injectafer will depend on your individual needs, including the severity of your anemia and your body weight. Your healthcare provider will calculate the appropriate dose for you.
• Administration: Injectafer is administered through an intravenous (IV) infusion. A healthcare professional will typically administer it in a healthcare facility, such as a hospital or clinic. The infusion is given slowly, usually over a period of 15 minutes for a dose of up to 750 mg, or over 30 minutes for a dose higher than 750 mg.
• Monitoring: After receiving Injectafer, your healthcare provider may monitor you for a short period to observe for any immediate adverse reactions. They may also monitor your blood iron levels periodically to assess the effectiveness of the treatment.
• Follow-up: Your healthcare provider will determine the frequency and duration of your Injectafer treatment based on your response to therapy and any underlying conditions you may have. They will also advise you on whether additional iron supplementation is necessary after the initial treatment.

It is crucial to inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking before starting Injectafer. They will be able to provide you with personalized guidance and address any specific concerns or questions you may have.

Other uses for this medicine

There are some off-label uses for Injectafer that have been explored or prescribed in certain cases. It’s important to note that off-label use means the medication is being used in a manner not specifically approved by regulatory authorities. Some potential off-label uses for Injectafer include:

• Iron deficiency anemia in pediatric patients: While Injectafer is not approved for use in children, healthcare providers may consider it in certain cases where oral iron supplementation is not effective or tolerated.
• Pregnancy-related iron deficiency anemia: Pregnant women who experience severe iron deficiency anemia and cannot tolerate oral iron supplements may be considered for treatment with Injectafer.
• Inflammatory bowel disease (IBD): Some studies have explored the use of Injectafer in patients with IBD who have iron deficiency anemia. It may be considered when oral iron supplementation is ineffective or not tolerated.

What special precautions should I follow?

Regarding special precautions for Injectafer, here are a few key points to consider:

• Allergy or hypersensitivity: Inform your healthcare provider if you have a known allergy or hypersensitivity to Injectafer or any of its components. Severe allergic reactions may occur, although they are rare.
• Iron overload: Injectafer should not be used in patients with iron overload conditions such as hemochromatosis or hemosiderosis.
• Infections: Injectafer may increase the risk of certain infections. It should be used with caution in patients with active infections or a history of recurrent infections.
• Monitoring and follow-up: Regular monitoring of hemoglobin levels and iron parameters is necessary during and after treatment with Injectafer. Your healthcare provider will determine the appropriate monitoring schedule for you.
• Potential interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as they may interact with Injectafer.

Always follow your healthcare provider’s instructions and discuss any concerns or questions you have about Injectafer and its precautions.

What special dietary instructions should I follow?

Your healthcare provider may recommend certain dietary considerations while taking Injectafer, such as consuming foods rich in iron. These may include foods like lean meats, poultry, fish, leafy green vegetables, fortified cereals, and beans. However, it’s essential to follow the specific instructions provided by your healthcare provider as individual needs may vary.

What should I do if I forget a dose?

If you forget to take an Injectafer dose, contact your healthcare provider or infusion center for guidance. They will be able to advise you on the best course of action based on your individual circumstances. It’s generally important to adhere to the recommended dosing schedule for optimal results, but your healthcare provider will determine the best approach for you.

What side effects can this medication cause?

Injectafer (ferric carboxymaltose) is an intravenous iron supplement used to treat iron deficiency anemia in adults. While it is generally considered safe and well-tolerated, like any medication, it can cause side effects in some individuals. Common side effects of Injectafer may include:

• Gastrointestinal disturbances: These can include nausea, vomiting, stomach pain, constipation, diarrhea, or a metallic taste in the mouth.
• Hypersensitivity reactions: Some individuals may experience allergic reactions to Injectafer. Symptoms can range from mild to severe and may include itching, rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, or tightness in the chest. If any signs of an allergic reaction occur, immediate medical attention should be sought.
• Injection site reactions: Injectafer is administered intravenously, and some people may experience pain, swelling, redness, or irritation at the injection site.
• Dizziness or headache: These side effects are relatively uncommon but have been reported in some individuals using Injectafer.
• Changes in blood pressure: Injectafer can cause changes in blood pressure, including both increases and decreases. Blood pressure should be monitored during and after administration.

It’s important to note that these side effects are not exhaustive, and some individuals may experience other adverse reactions. If you have any concerns or experience any unusual symptoms after receiving Injectafer, it is advisable to consult your healthcare provider for further evaluation and guidance. They can provide personalized information based on your specific medical history.

What should I know about storage and disposal of this medication?

1. Storage:
   • Injectafer should be stored at controlled room temperature, typically between 20°C and 25°C (68°F to 77°F).
   • Protect the vials from light by keeping them in the original carton until ready for use.
   • Do not freeze Injectafer or use it if it has been frozen.
2. Disposal:
   • Unused or expired Injectafer vials should be disposed of properly and in accordance with local regulations or guidelines.
   • Consult your healthcare provider, pharmacist, or local waste management authorities for specific instructions on how to dispose of Injectafer safely.

In case of emergency/overdose

• Call emergency services: If someone is experiencing severe symptoms or is unresponsive, call emergency services right away.
• Contact a healthcare professional: Inform a healthcare professional about the situation, providing details about the person, the medication involved (Injectafer), and the suspected overdose.

What other information should I know?

• Unless specifically instructed by a healthcare professional or poison control center, do not induce vomiting as a response to an overdose.
• When seeking medical help, have as much information as possible available, including the amount of Injectafer taken, the time it was taken, and any symptoms experienced.

It is essential to consult the prescribing healthcare professional or read the medication package insert for complete and accurate information about Injectafer, including potential side effects, contraindications, and precautions. Always follow the instructions provided by your healthcare provider regarding the use and administration of Injectafer.