WARNING

Studies have shown that older adults who take antipsychotics (medications for mental illness) like ziprasidone have a higher risk of dying while receiving treatment. Dementia is a brain disorder that affects memory, thinking clearly, communication, and daily activities as well as possibly causing changes in mood and personality. Additionally, older people with dementia may be more likely to get a stroke or mini-stroke while receiving treatment.

The Food and Drug Administration (FDA) has not approved ziprasidone for the management of behavioral issues in dementia-affected older individuals. If you, a family member, or a person you care for has dementia and is taking ziprasidone, speak with the doctor who recommended it.

Why is this medication prescribed?

Ziprasidone is a medication that is primarily prescribed for the treatment of certain mental disorders, including schizophrenia and bipolar disorder. It belongs to a class of medications called atypical antipsychotics.

In the case of schizophrenia, ziprasidone helps to alleviate symptoms such as hallucinations (seeing or hearing things that are not there), delusions (false beliefs), disorganized thinking, and emotional instability. For bipolar disorder, it is used to manage manic or mixed episodes, which involve symptoms like excessive energy, racing thoughts, and impulsivity.

How should this medicine be used?

Ziprasidone should be used as directed by a healthcare professional, typically in the form of oral capsules or an injection. The dosage and duration of treatment will depend on the individual’s condition and response to the medication. It is important to follow the prescribed dosage schedule and not to adjust or discontinue the medication without consulting a doctor.

The capsules are usually taken with food to enhance absorption. It is important to swallow the capsules whole, without crushing or chewing them. For the injectable form, a healthcare professional will administer the medication, typically into a muscle.

It is essential to adhere to the prescribed regimen, even if symptoms improve, as abruptly stopping the medication may lead to a recurrence of symptoms. If there are any concerns or questions about the use of ziprasidone, it is best to consult with a healthcare provider for guidance and clarification.

Other uses for this medicine

Ziprasidone is primarily used as an antipsychotic medication to treat symptoms of schizophrenia and bipolar disorder. However, there may be other off-label uses for Ziprasidone as determined by healthcare professionals. Some potential off-label uses include the treatment of anxiety disorders, depression, and certain behavioral disorders.

It is important to note that the off-label use of any medication should only be done under the guidance and prescription of a qualified healthcare provider. They will assess your specific situation and determine if Ziprasidone or an alternative medication is appropriate for your needs.

What special precautions should I follow?

When taking Ziprasidone or any medication, it is essential to follow the special precautions provided by your healthcare provider. Here are some general precautions associated with Ziprasidone:

• Medical history: Inform your healthcare provider about your complete medical history, including any allergies, current medical conditions, or past reactions to medications.
• Medication interactions: Provide a list of all medications, supplements, or herbal products you are currently taking to your healthcare provider to avoid any potential interactions. Ziprasidone may interact with certain medications, such as antihypertensive drugs, antidepressants, and medications that affect heart rhythm.
• Heart conditions: Inform your healthcare provider if you have a history of heart problems, including heart disease, heart rhythm disorders, or a recent heart attack. Ziprasidone may increase the risk of irregular heart rhythms, so caution is necessary.
• Blood pressure: Ziprasidone can potentially cause changes in blood pressure. Regular monitoring of blood pressure is important during treatment.
• Elderly population: Older adults may be more susceptible to certain side effects of Ziprasidone, such as dizziness, fainting, and irregular heart rhythms. Close monitoring is advised.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Ziprasidone with your healthcare provider. The use of Ziprasidone during pregnancy or breastfeeding should be carefully evaluated.
• Alcohol and sedatives: Avoid consuming alcohol or using sedative medications while taking Ziprasidone, as they may increase drowsiness and dizziness.

What special dietary instructions should I follow?

Ziprasidone is an atypical antipsychotic medication used to treat certain mental health conditions such as schizophrenia and bipolar disorder. While there are no specific dietary restrictions for Ziprasidone, it’s generally recommended to follow a healthy and balanced diet while taking any medication. Here are some general guidelines to consider:

• Consistency: Try to maintain a consistent eating pattern by having regular meals at similar times each day. This can help minimize fluctuations in blood sugar levels and potentially reduce side effects.
• Nutrient-rich diet: Focus on consuming a diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats. This can support overall health and provide essential nutrients your body needs.
• Hydration: Stay adequately hydrated by drinking enough water throughout the day. Avoid excessive consumption of caffeine or alcohol, as they can interact with Ziprasidone and affect its effectiveness.
• Drug-food interactions: While Ziprasidone does not have any significant food interactions, it’s still a good idea to discuss potential interactions with your healthcare provider or pharmacist, especially if you have any specific dietary concerns or restrictions.
• Weight management: Some individuals may experience weight changes while taking Ziprasidone. If weight gain becomes a concern for you, speak with your healthcare provider. They can provide guidance on maintaining a healthy weight through proper diet and exercise.

What should I do if I forget a dose?

If you forget to take a dose of ziprasidone, it’s best to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed dose, as this can increase the risk of side effects. It’s important to maintain a consistent dosing schedule with ziprasidone, so try to take it at the same time each day to ensure optimal effectiveness.

What side effects can this medication cause?

Ziprasidone is an antipsychotic medication used to treat schizophrenia and bipolar disorder. Like all medications, it can potentially cause side effects. Some of the common side effects associated with ziprasidone include:

• Drowsiness: Ziprasidone may cause drowsiness or sedation, which can affect concentration and reaction time.
• Dizziness: Some individuals may experience dizziness or lightheadedness when taking ziprasidone. It is important to be cautious when performing activities that require alertness, such as driving or operating machinery.
• Nausea and gastrointestinal disturbances: Ziprasidone can cause gastrointestinal side effects, including nausea, vomiting, constipation, or diarrhea. Taking the medication with food can help minimize these symptoms.
• Dry mouth: Ziprasidone may cause dry mouth, leading to discomfort or an increased risk of dental problems. Maintaining good oral hygiene and staying hydrated can help alleviate this side effect.
• Headache: Some individuals may experience headaches while taking ziprasidone. If the headaches persist or become severe, it is important to consult a healthcare professional.
• Restlessness or akathisia: Ziprasidone can cause a sense of restlessness or an inability to sit still, known as akathisia. If this side effect occurs, it is important to inform your healthcare provider.
• Extrapyramidal symptoms: These are movement disorders that can occur with antipsychotic medications. Symptoms may include tremors, muscle stiffness, muscle spasms, or abnormal movements. If any of these symptoms occur, it is important to contact your healthcare provider.
• Weight gain: Some individuals may experience weight gain while taking ziprasidone. Adopting a healthy lifestyle with regular exercise and a balanced diet can help manage weight.
• Changes in blood sugar and lipid levels: Ziprasidone can affect blood sugar levels and lipid (cholesterol and triglyceride) levels. Regular monitoring of these parameters may be necessary during treatment.
• QT interval prolongation: Ziprasidone has the potential to prolong the QT interval, which can lead to a serious heart rhythm disorder. It is important to inform your healthcare provider if you have a history of heart problems or if you experience symptoms such as rapid or irregular heartbeat, fainting, or dizziness.

What should I know about storage and disposal of this medication?

Ziprasidone is a medication commonly prescribed to treat certain mental/mood disorders such as schizophrenia and bipolar disorder. Here are some important points to know about its storage, disposal, and what to do in case of an emergency or overdose:

Storage:

• Keep Ziprasidone in its original container with the lid tightly closed.
• Store it at room temperature, away from moisture, heat, and direct light.
• Avoid storing it in the bathroom or any area with high humidity or temperature fluctuations.
• Keep it out of reach of children and pets.

Disposal:

• Do not flush Ziprasidone down the toilet or pour it into a drain unless instructed to do so.
• If no specific disposal instructions are provided, consult your local waste management or pharmacy for guidance on how to dispose of the medication safely.
• Discard expired or unused Ziprasidone properly to prevent accidental ingestion.

In case of emergency/overdose

• If someone has overdosed or experienced a serious reaction after taking Ziprasidone, call emergency services immediately (911 in the United States).
• Stay with the person until help arrives and provide necessary information, including the name of the medication taken, the dosage, and the time it was ingested.
• If possible, have the medication packaging or container available to provide additional details to medical professionals.

What other information should I know?

• Always take Ziprasidone exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking it without consulting your doctor.
• Inform your doctor about any other medications, vitamins, or supplements you are taking, as certain drugs may interact with Ziprasidone.
• Avoid consuming alcohol while taking Ziprasidone, as it can enhance certain side effects.
• Ziprasidone may cause drowsiness, so use caution while operating machinery or engaging in activities requiring mental alertness until you know how the medication affects you.
• Contact your healthcare provider if you experience any severe or persistent side effects while taking Ziprasidone.

Remember, it is essential to consult your healthcare provider or pharmacist for specific instructions and advice regarding the storage, disposal, and appropriate actions in case of an emergency or overdose related to Ziprasidone.