WARNING

The use of estrogen vaginal therapy carries certain risks, including:

• Increased risk of blood clots: Estrogen therapy, including vaginal estrogen, may increase the risk of developing blood clots, which can lead to serious conditions such as deep vein thrombosis or pulmonary embolism.
• Increased risk of certain cancers: Long-term use of estrogen vaginal therapy may be associated with an increased risk of certain types of cancer, including breast cancer and endometrial cancer.
• Increased risk of stroke and heart disease: Estrogen therapy may slightly increase the risk of stroke and heart disease, particularly in postmenopausal women who have pre-existing risk factors such as high blood pressure, diabetes, or smoking.
• Vaginal irritation and discharge: Some individuals may experience vaginal irritation, discharge, itching, or discomfort as side effects of estrogen vaginal therapy.
• Breast tenderness and enlargement: Estrogen therapy can cause breast tenderness or swelling in some individuals.
• Nausea and other gastrointestinal symptoms: Some people may experience feelings of nausea or an upset stomach while using estrogen vaginal products.
• Breakthrough bleeding and spotting: Estrogen vaginal therapy may cause irregular vaginal bleeding or spotting, especially during the first few months of treatment.
• Allergic reactions: Although rare, allergic reactions to estrogen vaginal products can occur, leading to symptoms such as itching, rash, hives, or difficulty breathing.

It’s essential to weigh the potential risks and benefits of estrogen vaginal therapy with your healthcare provider before starting treatment. Your doctor can help you determine if estrogen vaginal therapy is appropriate for you based on your individual medical history, symptoms, and risk factors. Additionally, attending regular follow-up appointments and monitoring for any changes in symptoms or side effects is crucial while using estrogen vaginal therapy.

Why is this medication prescribed?

Estrogen vaginal is prescribed primarily to treat symptoms of vaginal atrophy, a condition that commonly occurs during menopause when estrogen levels decline. Vaginal atrophy can cause symptoms such as vaginal dryness, itching, burning, painful intercourse, and urinary symptoms like urgency and frequency. Estrogen vaginal helps to alleviate these symptoms by replenishing estrogen levels locally in the vaginal tissue.

How should this medicine be used?

Estrogen vaginal is typically available in various forms such as creams, tablets, rings, or inserts, and the method of use may vary depending on the specific product. However, here are general guidelines for using estrogen vaginal:

• Creams: Creams are usually applied directly into the vagina using an applicator provided with the product. The recommended dosage and frequency of application will be provided by your healthcare provider. It’s important to follow the instructions carefully.
• Tablets: Vaginal estrogen tablets are inserted into the vagina using an applicator. The frequency of insertion and dosage will be prescribed by your doctor.
• Rings: Vaginal estrogen rings are inserted into the vagina by the patient or healthcare provider. The ring releases a continuous low dose of estrogen over time. The ring is typically replaced every three months.
• Inserts: Vaginal estrogen inserts are small, soft pellets that are inserted into the vagina using an applicator. The frequency of insertion and dosage will be determined by your healthcare provider.

It’s important to use estrogen vaginal exactly as prescribed by your doctor. If you have any questions or concerns about how to use the product, be sure to consult with your healthcare provider or pharmacist for clarification. Additionally, it’s important to attend regular follow-up appointments with your doctor to monitor your response to treatment and to discuss any potential side effects or changes in your symptoms.

Other uses for this medicine

While estrogen vaginal is primarily prescribed for treating symptoms of vaginal atrophy, there are other potential uses for this medication. These may include:

• Treatment of vaginal dryness or discomfort caused by hormonal changes during breastfeeding or certain medical conditions.
• Management of vaginal symptoms associated with certain cancer treatments or surgical menopause.
• Prevention of recurrent urinary tract infections in postmenopausal women.

What special precautions should I follow?

Regarding special precautions for using estrogen vaginal, here are some important points to consider:

• Medical history: Before using estrogen vaginal, inform your healthcare provider about any medical conditions you have, especially if you have a history of breast cancer, uterine cancer, blood clots, stroke, heart disease, liver disease, or abnormal vaginal bleeding.
• Pregnancy and breastfeeding: Estrogen vaginal is generally not recommended for use during pregnancy or breastfeeding unless specifically prescribed by a doctor. It’s important to discuss the potential risks and benefits with your healthcare provider.
• Regular check-ups: While using estrogen vaginal, it’s essential to attend regular follow-up appointments with your doctor for monitoring and evaluation of your symptoms and response to treatment.
• Side effects: Like any medication, estrogen vaginal may cause side effects, including vaginal irritation, discharge, itching, and breast tenderness. If you experience any bothersome or persistent side effects, inform your doctor.
• Interaction with other medications: Before using estrogen vaginal, inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, herbal supplements, and vitamins, to avoid potential drug interactions.
• Routine screenings: Estrogen therapy may increase the risk of certain health conditions, such as breast cancer, endometrial cancer, and blood clots. Therefore, your doctor may recommend regular screenings and monitoring to assess your overall health and detect any potential complications early.

Always follow your healthcare provider’s instructions and guidance regarding the use of estrogen vaginal, and do not hesitate to ask any questions or seek clarification if needed.

What special dietary instructions should I follow?

As for special dietary instructions for estrogen vaginal, there are typically no specific dietary restrictions associated with its use. However, maintaining a balanced and healthy diet is always beneficial for overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of estrogen vaginal, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Estrogen vaginal, like any medication, can cause side effects, although not everyone will experience them. Some potential side effects of estrogen vaginal may include:

• Vaginal irritation: This may manifest as itching, burning, or redness in the vaginal area.
• Vaginal discharge: You may experience changes in vaginal discharge, including an increase or a change in consistency.
• Breast tenderness: Some individuals may experience tenderness or swelling of the breasts.
• Headache: Headaches can occur as a side effect of estrogen therapy.
• Nausea: Some people may experience feelings of nausea or an upset stomach.
• Fluid retention: Estrogen therapy can sometimes cause fluid retention, leading to swelling in the hands, feet, or ankles.
• Mood changes: Mood swings or changes in emotional state may occur in some individuals.
• Spotting or breakthrough bleeding: Estrogen vaginal therapy may cause irregular vaginal bleeding or spotting, especially during the first few months of treatment.
• Allergic reactions: Although rare, some individuals may experience allergic reactions to estrogen vaginal products, which can manifest as itching, rash, hives, or difficulty breathing.
• Increased risk of certain health conditions: Long-term use of estrogen therapy may be associated with an increased risk of certain health conditions, such as breast cancer, endometrial cancer, blood clots, and cardiovascular events.

It’s essential to discuss any potential side effects with your healthcare provider before starting estrogen vaginal therapy. If you experience any bothersome or persistent side effects while using this medication, contact your doctor for further evaluation and guidance. Additionally, seek immediate medical attention if you experience symptoms of a severe allergic reaction or other serious side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Store estrogen vaginal products at room temperature away from moisture, heat, and light. Follow the specific storage instructions provided with the product.
• Keep estrogen vaginal medications out of reach of children and pets.
• Do not flush estrogen vaginal products down the toilet or pour them into a drain unless instructed to do so. Dispose of unused or expired medications properly according to local regulations. You can consult your pharmacist or local waste disposal authority for guidance on how to dispose of medications safely.

In case of emergency/overdose

• In case of an emergency or overdose, such as accidental ingestion or excessive use of estrogen vaginal products, seek medical attention immediately.
• If possible, bring the medication container or packaging to the healthcare provider or emergency room to aid in treatment.
• Symptoms of estrogen overdose may include nausea, vomiting, vaginal bleeding, breast tenderness, and fluid retention. Prompt medical attention is essential to manage these symptoms effectively.

What other information should I know?

• Inform all healthcare providers involved in your care, including doctors, dentists, and pharmacists, about your use of estrogen vaginal products. This includes both prescription and over-the-counter medications, as well as any herbal supplements or vitamins.
• Attend regular follow-up appointments with your healthcare provider to monitor your response to treatment and discuss any concerns or changes in symptoms.
• Be aware of the signs and symptoms of potential side effects or complications associated with estrogen vaginal therapy. If you experience any unusual or bothersome symptoms, contact your doctor for evaluation and guidance.
• Follow the prescribed dosage and administration instructions provided by your healthcare provider. Do not use more or less of the medication than prescribed, and do not stop using it without consulting your doctor.
• If you have any questions or concerns about estrogen vaginal therapy, including its use, side effects, or storage, consult your healthcare provider or pharmacist for assistance and clarification.