Why is this medication prescribed?

Extavia is prescribed primarily for the treatment of multiple sclerosis (MS), particularly for individuals with relapsing forms of the disease. MS is a chronic autoimmune disorder where the immune system attacks the protective covering of nerve fibers in the brain and spinal cord, leading to communication problems between the brain and the rest of the body.

Extavia belongs to a class of medications called interferon beta-1b, which are considered disease-modifying therapies (DMTs). Disease-modifying therapies work by modifying the immune system’s response to reduce inflammation, decrease the frequency and severity of MS relapses, and slow down the progression of disability associated with the disease.

Extavia is specifically indicated for reducing the frequency of relapses and delaying the accumulation of physical disability in patients with relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. It is not a cure for MS, but it can help manage symptoms and improve overall quality of life for many individuals living with the condition.

How should this medicine be used?

Extavia is typically administered as a subcutaneous injection. Here are general guidelines on how it should be used:

• Preparation: Wash your hands thoroughly with soap and water. Gather all the necessary supplies, including the Extavia vial, syringe, needle, alcohol wipes, and a puncture-resistant disposal container.
• Vial Preparation: Check the expiration date on the vial. If the medication is cloudy or contains particles, do not use it. Clean the rubber stopper of the vial with an alcohol wipe. Allow it to dry before proceeding.
• Drawing Up the Medication: Use a syringe and needle provided by your healthcare provider. Remove the needle cover, and draw air into the syringe equal to the amount of Extavia prescribed. Insert the needle into the vial, and inject the air. Turn the vial and syringe upside down, making sure the needle tip is below the fluid level. Draw the prescribed dose of Extavia into the syringe.
• Injection Site Preparation: Choose a clean, dry injection site, such as the thigh, abdomen, or upper arm. Avoid injecting into areas with broken or irritated skin, scars, or areas with visible veins. Rotate injection sites to minimize discomfort and tissue damage.
• Injection: Pinch the skin at the injection site. Insert the needle into the skin at a 45 to 90-degree angle, depending on the thickness of the skin and the length of the needle. Push the plunger to inject the medication slowly. Once the medication is injected, remove the needle and release the pinch on the skin. Dispose of the needle and syringe in a puncture-resistant container.
• Aftercare: Apply gentle pressure to the injection site with a cotton ball or gauze pad if there is any bleeding. Do not rub the injection site. Dispose of all used materials properly.

It’s essential to follow the specific instructions provided by your healthcare provider, as dosing and injection techniques may vary based on individual factors. They can also provide guidance on managing any side effects and how to properly store Extavia.

Other uses for this medicine

Extavia (interferon beta-1b) is primarily prescribed for the treatment of multiple sclerosis (MS), particularly for individuals with relapsing forms of the disease. However, it’s worth noting that Extavia is not approved for other uses beyond MS treatment. Its effectiveness and safety for other conditions have not been established.

What special precautions should I follow?

As for special precautions to follow when using Extavia:

• Allergies: Inform your healthcare provider if you are allergic to interferon beta-1b or any other medications. It’s crucial to disclose any known allergies to ensure the medication is safe for you.
• Medical History: Provide your healthcare provider with a comprehensive medical history, including any previous or current medical conditions, especially if you have a history of depression, liver disease, thyroid problems, or seizures.
• Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, discuss the risks and benefits of using Extavia with your healthcare provider. It is not recommended during pregnancy unless the potential benefits outweigh the risks. Similarly, it’s important to consult with your healthcare provider if you are breastfeeding, as it’s unclear whether Extavia passes into breast milk.
• Infections: Extavia may increase the risk of certain infections, including serious infections such as progressive multifocal leukoencephalopathy (PML). Inform your healthcare provider if you develop symptoms of infection, such as fever, chills, sore throat, or flu-like symptoms.
• Liver Function: Regular monitoring of liver function tests may be necessary while taking Extavia, as it may cause liver problems. Inform your healthcare provider if you experience symptoms such as yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unusual tiredness.
• Mental Health: Interferon beta-1b medications, including Extavia, may exacerbate or cause depression, suicidal thoughts, or mood changes. Inform your healthcare provider if you experience mood changes, depression, or suicidal thoughts while taking Extavia.
• Other Medications: Inform your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking, as they may interact with Extavia.

Always follow your healthcare provider’s instructions and guidance when using Extavia, and do not hesitate to ask questions or seek clarification about any concerns you may have regarding its use.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Extavia. However, maintaining a healthy and balanced diet is generally recommended to support overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of Extavia, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure about what to do, contact your healthcare provider or pharmacist for guidance. It’s important to try to maintain a consistent dosing schedule to maximize the effectiveness of the medication.

What side effects can this medication cause?

Extavia, like any medication, can cause side effects, although not everyone will experience them. Some common side effects of Extavia include:

• Injection site reactions: These can include redness, pain, swelling, itching, or bruising at the injection site.
• Flu-like symptoms: These may include fever, chills, muscle aches, fatigue, and headache. These symptoms often occur after starting treatment but may decrease over time.
• Fatigue: Feeling tired or exhausted is a common side effect of Extavia.
• Nausea: Some individuals may experience nausea or vomiting as a side effect of the medication.
• Muscle and joint pain: Extavia may cause muscle or joint pain in some individuals.
• Fever: Elevated body temperature can occur as a side effect of Extavia.
• Headache: Headaches are a common side effect of interferon beta medications like Extavia.
• Depression or mood changes: Some individuals may experience changes in mood or symptoms of depression while taking Extavia.
• Liver problems: Extavia can affect liver function in some people, leading to elevated liver enzymes or other liver-related issues.
• Blood disorders: Rarely, Extavia may cause changes in blood cell counts, such as decreased white blood cell count or decreased platelet count.

It’s essential to report any side effects you experience to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment regimen if necessary. Additionally, seek medical attention if you experience severe or persistent side effects, such as signs of liver problems or severe depression.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal of Extavia:

• Storage: Extavia should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). Do not freeze. Keep the medication in its original carton to protect it from light. Do not use Extavia if it has been frozen or if the expiration date has passed.
• Unused Medication: If you have any unused Extavia or syringes, dispose of them properly according to local regulations or as instructed by your healthcare provider or pharmacist.
• Disposal: Used needles and syringes should be placed in a puncture-resistant container and disposed of properly. Do not throw them in the household trash. Your healthcare provider or pharmacist can provide guidance on proper disposal methods.

In case of emergency/overdose

In case of emergency or overdose of Extavia, seek medical attention immediately. Symptoms of an overdose may include severe flu-like symptoms, such as high fever, severe muscle aches, or extreme fatigue. It’s important to inform emergency medical personnel that you are taking Extavia so they can provide appropriate treatment.

What other information should I know?

• Keep all appointments with your healthcare provider for regular monitoring and evaluation of your condition while taking Extavia.
• Inform all healthcare providers involved in your care that you are taking Extavia, especially if you are scheduled for surgery or any medical procedures.
• Do not share your Extavia medication or syringes with others, even if they have the same condition.
• Keep Extavia and all medications out of the reach of children and pets.
• Follow your healthcare provider’s instructions carefully for proper injection technique and dosage administration.
• Contact your healthcare provider if you have any questions or concerns about your treatment with Extavia.

By following these guidelines and staying informed about your medication, you can help ensure safe and effective use of Extavia for the management of your condition.