WARNING

Evamist is a prescription medication used to treat symptoms of menopause, such as hot flashes and vaginal dryness, by delivering estrogen through a spray applied to the skin. Like any medication, Evamist carries certain risks, including:

• Increased risk of blood clots: Estrogen therapy, including Evamist, may increase the risk of blood clots, which can lead to serious conditions like stroke, heart attack, or pulmonary embolism.
• Increased risk of certain cancers: Long-term use of estrogen-alone therapy, like Evamist, has been associated with a slightly increased risk of endometrial cancer. Combining estrogen with progestin may reduce this risk. Additionally, some studies suggest a slightly increased risk of breast cancer with estrogen therapy.
• Stroke and heart attack: Estrogen therapy may increase the risk of stroke and heart attack, particularly in women with pre-existing risk factors such as high blood pressure, diabetes, or smoking.
• Gallbladder disease: Estrogen therapy, including Evamist, may increase the risk of gallbladder disease, especially in women already at risk.
• Other side effects: Evamist may cause side effects such as headache, breast pain, vaginal bleeding, nausea, and skin irritation at the application site.

It’s essential for individuals considering Evamist or any hormone replacement therapy to discuss the potential risks and benefits with their healthcare provider, especially considering their individual medical history and risk factors. Hormone replacement therapy should be used at the lowest effective dose for the shortest duration necessary to manage symptoms. Regular follow-ups with a healthcare provider are also important to monitor for any adverse effects.

Why is this medication prescribed?

Evamist is prescribed to alleviate symptoms associated with menopause, particularly hot flashes and vaginal dryness. It contains estradiol, a form of estrogen hormone, which is delivered through a spray applied to the skin.

How should this medicine be used?

Here’s how Evamist is typically used:

• Application: Evamist comes in the form of a spray, usually in a pump bottle. It is applied to clean, dry skin on the inside of the forearm. Alternate application sites include the outside of the forearm or the inner thigh.
• Dosage: The dosage of Evamist varies depending on the individual’s symptoms and response to treatment. Your healthcare provider will determine the appropriate dosage for you.
• Administration: Before using Evamist, shake the bottle well. Hold the bottle upright and spray onto the skin as directed by your healthcare provider. Allow the spray to dry completely before dressing.
• Timing: Evamist is typically applied once daily, preferably at the same time each day. It’s important to use it regularly to experience its full benefits.
• Follow instructions: Follow the instructions provided by your healthcare provider and those included with the medication carefully. Do not exceed the prescribed dosage or alter the frequency of use without consulting your healthcare provider.
• Regular monitoring: Your healthcare provider may recommend periodic check-ups to monitor your response to Evamist and assess any potential side effects.

It’s important to note that Evamist should only be used by women who have undergone menopause and are experiencing symptoms that significantly affect their quality of life. Additionally, hormone replacement therapy, including Evamist, should be used at the lowest effective dose for the shortest duration necessary to manage symptoms.

Other uses for this medicine

As for other uses for Evamist, it is primarily indicated for the treatment of menopausal symptoms such as hot flashes. However, healthcare providers may sometimes prescribe it for other off-label uses, such as treating certain symptoms of vaginal atrophy (thin, dry vaginal walls) or osteoporosis prevention in certain women.

What special precautions should I follow?

When using Evamist, it’s essential to follow special precautions to minimize risks and optimize benefits. Here are some important precautions to consider:

• Medical history: Before starting Evamist, inform your healthcare provider about your complete medical history, including any past or present medical conditions, allergies, surgeries, medications (including over-the-counter and herbal supplements), and family history of breast cancer, blood clots, or other relevant conditions.
• Regular check-ups: Attend regular check-ups with your healthcare provider to monitor your response to Evamist, assess any side effects, and adjust the dosage if necessary. These check-ups also allow your healthcare provider to evaluate your overall health and determine the continued need for treatment.
• Risk factors: Discuss with your healthcare provider any risk factors that may increase your susceptibility to potential side effects of Evamist, such as a history of blood clots, stroke, heart disease, liver disease, gallbladder disease, or breast cancer. Your healthcare provider may recommend alternative treatment options or adjust the dosage accordingly.
• Breast health: Regularly perform breast self-examinations and undergo mammograms as recommended by your healthcare provider. Report any breast changes, lumps, or abnormalities to your healthcare provider promptly.
• Smoking: If you smoke, discuss smoking cessation strategies with your healthcare provider. Smoking while using Evamist may increase the risk of serious cardiovascular side effects, such as blood clots, stroke, and heart attack.
• Drug interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as they may interact with Evamist and affect its effectiveness or increase the risk of side effects.
• Pregnancy and breastfeeding: Evamist is not indicated for use during pregnancy. If you become pregnant while using Evamist, discontinue use immediately and consult your healthcare provider. It is also not recommended to use Evamist while breastfeeding, as estrogen can pass into breast milk and may harm the nursing infant.

By following these precautions and working closely with your healthcare provider, you can minimize risks and maximize the benefits of using Evamist for the management of menopausal symptoms.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with the use of Evamist. However, maintaining a balanced and healthy diet is generally recommended for overall health and well-being.

What should I do if I forget a dose?

If you miss a dose of estradiol topical, apply it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not apply extra medication to make up for a missed dose.

What side effects can this medication cause?

Evamist, like any medication, can cause side effects. Common side effects of Evamist may include:

• Headache
• Breast tenderness or pain
• Vaginal bleeding or spotting
• Nausea
• Irritation or redness at the application site
• Stomach cramps
• Bloating
• Mood changes
• Fluid retention
• Joint pain

Less common but more severe side effects of Evamist may include:

• Blood clots: Estrogen therapy, including Evamist, may increase the risk of blood clots, which can lead to serious conditions such as stroke, heart attack, or pulmonary embolism.
• Stroke or heart attack: Estrogen therapy may increase the risk of stroke or heart attack, particularly in women with pre-existing risk factors such as high blood pressure, diabetes, or smoking.
• Endometrial cancer: Long-term use of estrogen-alone therapy, like Evamist, has been associated with a slightly increased risk of endometrial cancer. Combining estrogen with progestin may reduce this risk.
• Breast cancer: Some studies suggest a slightly increased risk of breast cancer with estrogen therapy.
• Gallbladder disease: Estrogen therapy, including Evamist, may increase the risk of gallbladder disease, especially in women already at risk.

It’s essential to discuss any potential side effects or concerns with your healthcare provider before starting Evamist or any hormone replacement therapy. Additionally, seek medical attention if you experience severe or persistent side effects while using Evamist. Your healthcare provider can provide guidance on managing side effects and adjusting your treatment as needed.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Store Evamist at room temperature, away from heat, moisture, and direct light.
• Keep Evamist out of reach of children and pets.
• Do not puncture or incinerate the Evamist canister, even if it’s empty.
• Dispose of unused or expired Evamist properly according to local regulations or guidelines. You can consult your pharmacist or healthcare provider for advice on safe disposal methods.

In case of emergency/overdose

• In case of accidental ingestion or overdose of Evamist, seek emergency medical attention or contact a poison control center immediately.
• Symptoms of overdose may include nausea, vomiting, breast tenderness, vaginal bleeding, and other estrogen-related side effects.
• Be prepared to provide information about the amount of Evamist ingested and any symptoms experienced to medical professionals.

What other information should I know?

• Keep all appointments with your healthcare provider for regular check-ups and monitoring while using Evamist.
• Inform all healthcare providers involved in your care, including dentists and surgeons, about your use of Evamist.
• Avoid using Evamist if you have a known allergy to any of its ingredients.
• Inform your healthcare provider if you become pregnant or plan to become pregnant while using Evamist.
• Avoid applying Evamist to damaged, irritated, or sunburned skin.
• Do not apply Evamist to the breasts or genital area.
• Follow the instructions provided by your healthcare provider and those included with the medication carefully.
• Report any new or worsening symptoms to your healthcare provider promptly.

By following these guidelines and staying informed about the proper use, storage, and disposal of Evamist, you can help ensure its safe and effective use for managing menopausal symptoms.