Why is this medication prescribed?

Eribulin injection, marketed under the brand name Halaven, is prescribed for the treatment of certain types of cancer, primarily:

• Metastatic breast cancer: Eribulin is used to treat metastatic breast cancer, particularly in patients who have previously received at least two other types of chemotherapy medications.
• Liposarcoma: Eribulin is also indicated for the treatment of liposarcoma, a type of soft tissue sarcoma, in patients who have previously received chemotherapy.

Eribulin works by inhibiting the growth of cancer cells, thereby slowing down or halting the progression of the disease.

How should this medicine be used?

When it comes to how Eribulin injection should be used, it’s crucial to follow the specific instructions provided by a healthcare professional. Generally, Eribulin is administered intravenously (into a vein) over a period of time. The dosage and frequency of administration will depend on various factors such as the type and stage of cancer, the patient’s overall health, and any other ongoing treatments.

Before administering Eribulin, healthcare providers will assess the patient’s blood cell counts and overall health to ensure they are suitable candidates for treatment. Throughout the course of treatment, patients will be monitored closely for any signs of adverse reactions or side effects.

It’s important for patients to attend all scheduled appointments and follow-up visits with their healthcare providers to ensure the effectiveness of treatment and to manage any potential side effects. If a patient has any questions or concerns about using Eribulin injection, they should discuss them with their healthcare provider for clarification and guidance.

Other uses for this medicine

While Eribulin injection is primarily prescribed for the treatment of metastatic breast cancer and liposarcoma, it may sometimes be used off-label or investigational for other types of cancer. Off-label use refers to the use of a medication for a purpose other than what it is approved for by regulatory agencies like the FDA. Some healthcare providers may consider Eribulin for certain patients with other types of advanced or metastatic cancers, but this decision should be made on a case-by-case basis and carefully weighed against potential risks and benefits.

What special precautions should I follow?

As for special precautions to follow when using Eribulin injection, it’s essential to adhere to the following:

• Administration by healthcare professionals: Eribulin is administered intravenously by a healthcare provider in a clinical setting, such as a hospital or infusion center. Patients should not attempt to administer the medication themselves.
• Regular monitoring: Patients receiving Eribulin should undergo regular monitoring of their blood cell counts, liver function, and overall health status to detect any potential adverse effects or toxicities early on.
• Pre-existing conditions: Patients should inform their healthcare provider about any pre-existing medical conditions, especially heart disease, liver disease, or any nerve-related disorders, as these may affect the suitability of Eribulin treatment.
• Pregnancy and breastfeeding: Eribulin may cause harm to a developing fetus, so it is not recommended for use during pregnancy. Patients of childbearing potential should use effective contraception during treatment and for some time after the last dose. It is also not known whether Eribulin passes into breast milk, so breastfeeding is not recommended while receiving treatment.
• Allergic reactions: Patients should inform their healthcare provider of any known allergies to medications, especially if they have had a previous allergic reaction to Eribulin or any of its components.
• Medication interactions: Patients should disclose all medications, supplements, and herbal products they are taking to their healthcare provider to avoid potential interactions with Eribulin.
• Handling precautions: Healthcare providers should follow proper handling and disposal procedures for Eribulin injection to minimize the risk of exposure to the medication.

By following these precautions and working closely with their healthcare provider, patients can maximize the benefits of Eribulin treatment while minimizing potential risks and complications.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Eribulin injection. However, maintaining a balanced diet and staying hydrated can support overall health during cancer treatment. Your healthcare provider may recommend dietary changes or supplements based on your individual needs and any side effects you experience.

What should I do if I forget a dose?

If you miss a scheduled dose of Eribulin, contact your healthcare provider immediately for guidance. Depending on the timing and circumstances, they may advise you on whether to reschedule the missed dose or adjust your treatment plan accordingly. It’s essential to follow their instructions carefully and not try to make up for the missed dose without consulting them first.

What side effects can this medication cause?

Eribulin injection, like many chemotherapy medications, can cause various side effects. It’s important to note that not all patients will experience these side effects, and their severity can vary from person to person. Common side effects of Eribulin injection may include:

• Bone marrow suppression: Eribulin can lower the production of blood cells in the bone marrow, leading to anemia (low red blood cell count), leukopenia (low white blood cell count), and thrombocytopenia (low platelet count). This can increase the risk of infections, fatigue, and bleeding.
• Peripheral neuropathy: Eribulin may cause damage to the nerves outside the brain and spinal cord, resulting in symptoms such as numbness, tingling, weakness, and pain in the hands and feet.
• Fatigue: Many patients experience fatigue or weakness during Eribulin treatment.
• Nausea and vomiting: Eribulin can cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation.
• Hair loss: Some patients may experience hair loss or thinning while receiving Eribulin treatment.
• Muscle and joint pain: Eribulin may cause muscle and joint pain, which can range from mild to moderate in severity.
• Liver toxicity: In rare cases, Eribulin may lead to liver damage, resulting in elevated liver enzymes and jaundice.
• Heart problems: There have been reports of heart-related side effects such as abnormal heart rhythms and heart failure in patients receiving Eribulin, particularly those with pre-existing heart conditions.
• Allergic reactions: Some individuals may experience allergic reactions to Eribulin, which can manifest as rash, itching, swelling, or difficulty breathing.

It’s important for patients to report any side effects they experience to their healthcare provider promptly. Depending on the severity and nature of the side effects, adjustments to the treatment plan may be necessary to manage symptoms effectively. Healthcare providers can provide supportive care and medications to alleviate side effects and improve the patient’s quality of life during Eribulin treatment.

What should I know about storage and disposal of this medication?

Storage and disposal of Eribulin Injection:

• Storage: Eribulin Injection should be stored in its original packaging at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F). Protect the vials from light by keeping them in the original carton until ready for use. Do not freeze Eribulin Injection.
• Disposal: Properly dispose of any unused Eribulin Injection or empty vials according to local regulations for hazardous waste disposal. Do not dispose of medications in wastewater (e.g., down the sink or toilet) unless instructed to do so by a healthcare professional or pharmacist.

In case of emergency/overdose

In the event of an overdose or accidental exposure to a higher dose of Eribulin Injection than prescribed, seek immediate medical attention or contact a poison control center. Symptoms of overdose may include increased severity of side effects such as bone marrow suppression, peripheral neuropathy, gastrointestinal symptoms, and allergic reactions. Treatment of overdose will typically involve supportive measures to manage symptoms.

What other information should I know?

• Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Eribulin treatment and manage any side effects.
• Blood tests: Your healthcare provider may perform regular blood tests to monitor blood cell counts and liver function during Eribulin treatment. Inform your healthcare provider if you notice any signs of infection, bleeding, or jaundice.
• Avoid pregnancy: Eribulin may harm a developing fetus, so it’s important to use effective contraception during treatment and for some time after the last dose. Discuss family planning options with your healthcare provider.
• Inform healthcare providers: Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are receiving Eribulin treatment. This is important for potential interactions with other medications or procedures.
• Support services: Take advantage of support services available to cancer patients, such as counseling, support groups, and resources provided by healthcare facilities or cancer organizations. Managing cancer treatment can be challenging, and support services can provide valuable assistance and emotional support.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about the storage, disposal, administration, or potential side effects of Eribulin Injection.