WARNING

Estraderm is a medication containing estradiol, a form of estrogen hormone, typically used in hormone replacement therapy (HRT) to alleviate symptoms of menopause, such as hot flashes and vaginal dryness. Like any medication, it carries certain risks, including:

• Increased Risk of Blood Clots: Estrogen therapy, including Estraderm, may increase the risk of blood clots, which can lead to conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE).
• Increased Risk of Stroke and Heart Attack: Estrogen use may slightly increase the risk of stroke and heart attack, particularly in women who have other risk factors such as smoking, obesity, or a history of cardiovascular disease.
• Increased Risk of Endometrial Cancer: Women who have an intact uterus and take estrogen without a progestin (another hormone) are at an increased risk of developing endometrial cancer.
• Breast Cancer Risk: Some studies suggest that long-term use of estrogen therapy may be associated with a slightly increased risk of breast cancer.
• Gallbladder Disease: Estrogen therapy may increase the risk of developing gallbladder disease, such as gallstones.
• Other Side Effects: Common side effects of Estraderm and other estrogen therapies may include breast tenderness, nausea, bloating, headaches, mood changes, and vaginal bleeding.

It’s essential for individuals considering Estraderm or any estrogen therapy to discuss the potential risks and benefits with their healthcare provider, especially considering their individual medical history and risk factors. Hormone replacement therapy should be used at the lowest effective dose for the shortest duration necessary to achieve treatment goals. Regular monitoring and follow-up with a healthcare provider are crucial for managing potential risks associated with Estraderm use.

Why is this medication prescribed?

Estraderm is prescribed primarily for the management of symptoms associated with menopause, such as hot flashes, vaginal dryness, and other symptoms related to estrogen deficiency. It contains estradiol, which is a form of estrogen hormone. Estraderm is typically used as hormone replacement therapy (HRT) in menopausal women to supplement the declining levels of estrogen in the body.

How should this medicine be used?

The dosage and administration of Estraderm may vary depending on individual factors such as the severity of symptoms, medical history, and response to treatment. However, general guidelines for using Estraderm are as follows:

• Patch Application: Estraderm is available as a transdermal patch, which is applied to clean, dry skin on the lower abdomen or buttocks. It should not be applied to the breasts or any area that may be rubbed by tight clothing. Rotate application sites to minimize skin irritation.
• Frequency: The patch is typically worn continuously, with one patch applied and replaced every 7 days (weekly). Some healthcare providers may prescribe a cyclic regimen, where the patch is worn for 3 weeks followed by 1 week without a patch.
• Dosage: The dosage of Estraderm varies depending on the individual’s needs and medical condition. It’s important to use the lowest effective dose for the shortest duration necessary to achieve treatment goals. Dosage adjustments may be made by the healthcare provider based on response to treatment and monitoring of symptoms.
• Avoidance of Sun Exposure: Avoid exposing the application site to direct sunlight or extreme heat sources such as saunas or hot tubs while wearing the patch, as this may increase the absorption of estradiol and lead to adverse effects.
• Regular Monitoring: It’s essential to follow up with a healthcare provider regularly while using Estraderm to monitor response to treatment, assess any side effects, and adjust dosage if necessary.

It’s important to read the patient information leaflet provided with the medication and follow the instructions provided by the healthcare provider for the safe and effective use of Estraderm. If there are any questions or concerns about its use, it’s advisable to consult a healthcare professional.

Other uses for this medicine

Some alternative uses for Estraderm include:

• Hypoestrogenism: Estraderm may be used in women with ovarian failure or other conditions causing low estrogen levels.
• Osteoporosis Prevention: Estrogen therapy, including Estraderm, may be prescribed to prevent osteoporosis in postmenopausal women who are at risk of bone loss.
• Hormone Replacement in Transgender Care: Estraderm may be part of hormone replacement therapy for transgender individuals undergoing feminizing hormone therapy.

What special precautions should I follow?

As for special precautions to take while using Estraderm:

• Medical History: Before starting Estraderm, inform your healthcare provider about any medical conditions you have, especially if you have a history of breast cancer, blood clots, heart disease, stroke, liver disease, or gallbladder disease.
• Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some medications may interact with Estraderm.
• Regular Check-ups: Attend regular follow-up appointments with your healthcare provider for monitoring of your response to Estraderm and any potential side effects.
• Breast Examinations: Perform regular breast self-examinations and attend recommended mammograms as directed by your healthcare provider.
• Limitations: Estraderm should not be used by women who are pregnant or breastfeeding. It is also not indicated for use in individuals with a history of hormone-sensitive cancers.
• Smoking: If you smoke, discuss smoking cessation strategies with your healthcare provider, as smoking while using estrogen therapy may increase the risk of certain side effects such as blood clots and cardiovascular events.

Always follow your healthcare provider’s instructions and consult them with any questions or concerns about using Estraderm.

What special dietary instructions should I follow?

Special dietary instructions for Estraderm are generally not required. However, maintaining a healthy and balanced diet is important for overall health, especially during menopause. Your healthcare provider may recommend dietary changes or supplements based on your individual needs.

What should I do if I forget a dose?

If you forget to apply a dose of Estraderm, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra patches to make up for the missed dose. If you are unsure about what to do, consult your healthcare provider or pharmacist for advice.

What side effects can this medication cause?

Estraderm, like any medication, can cause side effects. Common side effects of Estraderm and other estrogen therapies may include:

• Breast Tenderness: Some individuals may experience breast tenderness or swelling.
• Nausea: Feeling nauseous or experiencing an upset stomach is a common side effect.
• Bloating: Some people may experience abdominal bloating or discomfort.
• Headaches: Headaches, including migraines, can occur as a side effect.
• Mood Changes: Mood swings, irritability, or changes in emotional state may occur.
• Vaginal Bleeding: Spotting or breakthrough bleeding may occur, particularly during the first few months of treatment.
• Skin Irritation: Irritation or redness at the patch application site is possible.
• Fluid Retention: Some individuals may experience fluid retention, leading to swelling in the hands, feet, or ankles.
• Increased Risk of Blood Clots: Estrogen therapy, including Estraderm, may increase the risk of blood clots, which can lead to conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE).
• Increased Risk of Stroke and Heart Attack: Estrogen use may slightly increase the risk of stroke and heart attack, particularly in women who have other risk factors such as smoking, obesity, or a history of cardiovascular disease.
• Increased Risk of Endometrial Cancer: Women who have an intact uterus and take estrogen without a progestin (another hormone) are at an increased risk of developing endometrial cancer.
• Breast Cancer Risk: Some studies suggest that long-term use of estrogen therapy may be associated with a slightly increased risk of breast cancer.
• Gallbladder Disease: Estrogen therapy may increase the risk of developing gallbladder disease, such as gallstones.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects not listed here. If you experience any persistent or severe side effects while using Estraderm, it’s important to contact your healthcare provider for further evaluation and guidance.

What should I know about storage and disposal of this medication?

Here’s what you should know about storage and disposal of Estraderm:

• Storage: Store Estraderm patches at room temperature away from moisture, heat, and light. Keep them out of reach of children and pets.
• Disposal: Dispose of used or expired Estraderm patches properly. Fold the patch in half with the sticky sides together, and discard it in a sealed container or pouch. Do not flush patches down the toilet.

In case of emergency/overdose

In case of emergency or overdose of Estraderm:

• Seek Medical Help: If you suspect an overdose or experience severe symptoms such as difficulty breathing, fainting, or chest pain, seek immediate medical attention by calling emergency services or going to the nearest emergency room.
• Poison Control: Contact a poison control center at 1-800-222-1222 (in the United States) or your local poison control center for guidance on what to do next.

What other information should I know?

• Follow Instructions: Use Estraderm patches exactly as prescribed by your healthcare provider. Do not use more patches or use them more frequently than recommended.
• Regular Monitoring: Attend regular follow-up appointments with your healthcare provider to monitor your response to Estraderm and any potential side effects.
• Inform Healthcare Providers: Inform other healthcare providers, such as dentists or specialists, that you are using Estraderm, as it may interact with other medications or affect certain medical procedures.
• Blood Clot Risk: Estrogen therapy, including Estraderm, may increase the risk of blood clots, especially in individuals with other risk factors such as obesity, smoking, or a history of blood clots.
• Breast Cancer Screening: Attend recommended breast cancer screenings such as mammograms as directed by your healthcare provider while using Estraderm.
• Skin Sensitivity: If you experience skin irritation or allergic reactions at the application site, contact your healthcare provider for guidance.
• Review Medication List: Periodically review your medication list with your healthcare provider to ensure the safe and appropriate use of all medications.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about using Estraderm.