Why is this medication prescribed?

Eluxadoline is a medication primarily prescribed for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. IBS-D is a gastrointestinal disorder characterized by abdominal pain or discomfort and frequent episodes of diarrhea.

Eluxadoline works by targeting certain receptors in the gastrointestinal tract, reducing bowel contractions and decreasing secretion of fluids into the intestines, which helps to alleviate diarrhea and associated symptoms.

How should this medicine be used?

Here are some guidelines for using Eluxadoline:

• Dosage: The typical dosage of Eluxadoline is usually 100 mg taken orally twice daily, with food.
• Follow Doctor’s Instructions: Always follow the dosage instructions provided by your doctor. Do not alter the dosage or stop taking the medication without consulting your healthcare provider.
• With Food: Eluxadoline should be taken with food to help reduce the risk of side effects and improve absorption.
• Swallow Whole: Swallow the tablets whole with water. Do not crush, chew, or break the tablets.
• Regular Use: It is important to take Eluxadoline regularly to experience its full benefits. Do not skip doses.
• Monitor Side Effects: Be aware of potential side effects such as constipation, nausea, abdominal pain, and pancreatitis. If you experience severe or persistent side effects, contact your doctor.
• Avoid Alcohol: It is recommended to avoid alcohol while taking Eluxadoline as it may increase the risk of side effects.
• Inform Healthcare Provider: Before starting Eluxadoline, inform your healthcare provider about any other medications, supplements, or medical conditions you have, as they may interact with Eluxadoline or affect its effectiveness.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Eluxadoline with your doctor.
• Storage: Store Eluxadoline at room temperature away from moisture and heat.

Always consult your healthcare provider for personalized advice regarding the appropriate use of Eluxadoline, as individual circumstances may vary.

Other uses for this medicine

Eluxadoline is primarily indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults, and its usage for other conditions is not common. However, there are no significant alternative uses for Eluxadoline beyond its approved indication for IBS-D.

What special precautions should I follow?

Regarding special precautions for Eluxadoline, here are some important points to consider:

• Medical History: Before taking Eluxadoline, inform your healthcare provider about your complete medical history, especially if you have a history of pancreatitis, liver problems, alcohol abuse, gallbladder problems, or any other gastrointestinal disorders.
• Allergies: Inform your doctor if you are allergic to Eluxadoline or any other medications.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Eluxadoline with your doctor. It is essential to weigh the potential risks to the fetus or infant against the benefits of treatment.
• Alcohol Consumption: Avoid alcohol consumption while taking Eluxadoline, as it may increase the risk of side effects such as pancreatitis.
• Driving and Operating Machinery: Eluxadoline may cause dizziness or drowsiness in some individuals. If you experience these side effects, avoid driving, operating heavy machinery, or engaging in activities that require alertness until you know how Eluxadoline affects you.
• Drug Interactions: Before starting Eluxadoline, inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking, as certain medications may interact with Eluxadoline and affect its effectiveness or increase the risk of side effects.
• Pancreatitis Risk: Eluxadoline has been associated with an increased risk of pancreatitis, a serious condition characterized by inflammation of the pancreas. If you experience symptoms such as severe abdominal pain that may radiate to your back, nausea, vomiting, or fever, seek immediate medical attention.
• Constipation Risk: Eluxadoline can cause constipation as a side effect. If you experience severe or persistent constipation while taking Eluxadoline, inform your doctor.
• Monitoring: Your healthcare provider may recommend regular monitoring of liver function tests while you are taking Eluxadoline.

Always follow your healthcare provider’s instructions and guidelines for the safe and effective use of Eluxadoline. If you have any questions or concerns about Eluxadoline or its precautions, consult your doctor or pharmacist for personalized advice.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Eluxadoline. However, taking Eluxadoline with food may help reduce the risk of side effects and improve absorption. It is generally recommended to take Eluxadoline with food to minimize the risk of gastrointestinal upset.

What should I do if I forget a dose?

If you forget to take a dose of Eluxadoline, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Eluxadoline, like any medication, can cause side effects, although not everyone experiences them. Common side effects of Eluxadoline may include:

• Constipation
• Nausea
• Abdominal pain or discomfort
• Headache
• Vomiting
• Gas or bloating
• Fatigue
• Dizziness

Less common but more serious side effects of Eluxadoline may include:

• Pancreatitis: Symptoms may include severe abdominal pain, especially if it radiates to the back, nausea, vomiting, or fever. Seek immediate medical attention if you experience these symptoms.
• Hypersensitivity reactions: This may include rash, itching, hives, swelling of the face, lips, tongue, throat, or difficulty breathing. Seek immediate medical attention if you experience any signs of a severe allergic reaction.
• Sphincter of Oddi spasm: This can cause symptoms such as severe abdominal pain or back pain. If you experience these symptoms, contact your healthcare provider.

It’s essential to report any side effects you experience while taking Eluxadoline to your healthcare provider. They can help determine if the side effects are manageable or if any adjustments to your treatment plan are necessary. Additionally, if you experience any severe or persistent side effects, seek medical attention promptly.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal of Eluxadoline:

Storage:

• Keep Eluxadoline tablets in the original container or packaging provided by the pharmacist.
• Store Eluxadoline at room temperature, away from moisture, heat, and direct light.
• Keep Eluxadoline out of reach of children and pets.
• Do not store Eluxadoline in the bathroom or near the kitchen sink where it might get wet.

Disposal:

• Dispose of any unused or expired Eluxadoline tablets properly.
• Do not flush Eluxadoline down the toilet or pour it down the drain unless instructed to do so.
• Consult your pharmacist or local waste disposal company for proper disposal guidelines. They may offer medication take-back programs or provide information on how to safely dispose of medications.

In case of emergency/overdose

• Contact emergency medical services immediately by calling your local emergency number (e.g., 911 in the United States) or go to the nearest emergency room.
• If possible, provide information about the amount of Eluxadoline ingested, when it was taken, and any symptoms experienced.
• Do not attempt to treat an overdose of Eluxadoline at home without medical supervision.

What other information should I know?

• Follow your healthcare provider’s instructions carefully regarding the use of Eluxadoline, including dosage, frequency, and duration of treatment.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with Eluxadoline.
• Attend all scheduled appointments with your healthcare provider for monitoring and follow-up.
• Keep a list of all medications you are taking, including prescription and over-the-counter medications, and share it with your healthcare provider.
• Be aware of potential side effects of Eluxadoline and report any new or worsening symptoms to your healthcare provider promptly.
• Avoid alcohol consumption while taking Eluxadoline, as it may increase the risk of side effects.
• If you have any questions or concerns about Eluxadoline or its use, consult your healthcare provider or pharmacist for further information and guidance.