Why is this medication prescribed?

Isavuconazonium sulfate (brand name Isavuconazonium Injection) is prescribed primarily for the treatment of invasive aspergillosis and invasive mucormycosis, which are serious fungal infections. It belongs to a class of medications known as azole antifungals.

Isavuconazonium Injection is prescribed when other antifungal treatments may not be suitable or have been ineffective. It is used in cases where the fungal infections are severe and potentially life-threatening, particularly in patients who are immunocompromised or have conditions that predispose them to fungal infections.

How should this medicine be used?

Here’s how Isavuconazonium Injection should typically be used:

• Administration: Isavuconazonium Injection is given intravenously (IV), meaning it is administered directly into the bloodstream through a vein. This is typically done in a hospital setting under the supervision of healthcare professionals.
• Dosage: The dosage of Isavuconazonium Injection depends on several factors, including the type and severity of the fungal infection, the patient’s weight, and overall health condition. It is important to follow the dosage instructions provided by the healthcare provider to ensure effective treatment.
• Treatment Course: The duration of treatment with Isavuconazonium Injection varies based on the specific fungal infection being treated and the patient’s response to the medication. Treatment may continue for several weeks or even months in some cases.
• Monitoring: Patients receiving Isavuconazonium Injection are usually monitored closely for any signs of adverse reactions or complications related to the medication or the underlying fungal infection.
• Precautions: It is important for patients to inform their healthcare provider about any other medications they are taking, including over-the-counter drugs, supplements, and herbal products, to avoid potential drug interactions.
• Completion of Treatment: Even if symptoms improve, it is crucial to complete the entire course of Isavuconazonium Injection as prescribed by the healthcare provider to ensure that the infection is fully treated and does not recur.

Overall, Isavuconazonium Injection is a potent antifungal medication used specifically for serious fungal infections where other treatment options may be limited or ineffective. Its use should be closely monitored by healthcare professionals to ensure safety and efficacy.

Other uses for this medicine

In some cases, healthcare providers may prescribe Isavuconazonium Injection for fungal infections that are resistant to other antifungal agents or for conditions not officially approved by regulatory authorities. This is known as off-label use and should be done with caution and consideration of available evidence.

What special precautions should I follow?

When using Isavuconazonium Injection, certain precautions should be followed to ensure safe and effective treatment:

• Allergies: Patients should inform their healthcare provider about any known allergies to Isavuconazonium or any other medications, particularly azole antifungals.
• Liver Function: Isavuconazonium can affect liver function, so patients with pre-existing liver disease or elevated liver enzymes should be monitored closely during treatment.
• Kidney Function: Renal function should also be monitored, as Isavuconazonium can potentially cause kidney problems in some patients.
• Drug Interactions: Isavuconazonium Injection can interact with other medications, including certain antibiotics, anticonvulsants, and immunosuppressants. It is important for healthcare providers to review the patient’s current medications to avoid harmful interactions.
• Pregnancy and Breastfeeding: The safety of Isavuconazonium Injection in pregnant or breastfeeding women has not been established. Therefore, it should only be used if the potential benefits outweigh the risks and under the guidance of a healthcare provider.
• Monitoring: Regular monitoring of kidney function, liver function, and electrolyte levels is recommended during treatment with Isavuconazonium Injection to detect any potential adverse effects early.
• Administration: Isavuconazonium Injection should be administered by healthcare professionals in a hospital or clinical setting where patients can be monitored for any adverse reactions.

Overall, Isavuconazonium Injection is a potent antifungal agent that requires careful monitoring and consideration of individual patient factors to ensure safe and effective treatment.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Isavuconazonium Injection. However, it’s generally advisable to maintain a healthy, balanced diet to support overall health and recovery from any illness. If you have any concerns about diet or nutrition while receiving this medication, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you miss a dose of Isavuconazonium Injection, contact your healthcare provider or healthcare team immediately for guidance. It’s important not to double the dose to make up for a missed one, as this can increase the risk of side effects or complications. Your healthcare provider will advise you on the appropriate next steps based on your specific treatment plan and condition.

What side effects can this medication cause?

Isavuconazonium Injection, like any medication, can cause side effects. It’s important to be aware of these potential side effects and to notify your healthcare provider if you experience any symptoms while receiving this medication. Common side effects and less common but serious side effects of Isavuconazonium Injection include:

Common Side Effects:

• Nausea
• Vomiting
• Headache
• Abnormal liver function tests (elevated liver enzymes)
• Diarrhea
• Increased blood pressure
• Peripheral edema (swelling of the hands, feet, or ankles)
• Cough
• Fatigue
• Decreased appetite

Less Common but Serious Side Effects:

• Severe allergic reactions (symptoms may include rash, itching/swelling, severe dizziness, trouble breathing)
• Liver problems (symptoms may include yellowing of the skin or eyes, dark urine, persistent nausea/vomiting, stomach/abdominal pain)
• Kidney problems (symptoms may include change in the amount of urine)
• Serious skin reactions (such as Stevens-Johnson syndrome or toxic epidermal necrolysis)
• Heart problems (such as abnormal heart rhythm)
• Severe gastrointestinal problems (such as severe abdominal pain, persistent nausea/vomiting, diarrhea)
• Pancreatitis (symptoms may include severe abdominal/stomach pain)
• Monitoring: Your healthcare provider will monitor you closely for any signs of these side effects during treatment with Isavuconazonium Injection.
• Reporting: If you experience any unusual or severe symptoms, notify your healthcare provider immediately.
• Allergies: Inform your healthcare provider about any known allergies to medications, especially azole antifungals.

If you experience side effects while receiving Isavuconazonium Injection, it’s important to follow these steps:

• Contact Healthcare Provider: Notify your healthcare provider promptly. They may recommend adjusting your treatment plan or providing supportive care to manage side effects.
• Emergency: Seek immediate medical attention if you experience symptoms of a severe allergic reaction, such as rash, itching/swelling, severe dizziness, or trouble breathing.

By being informed about the potential side effects of Isavuconazonium Injection and closely monitoring your symptoms, you can work with your healthcare team to ensure safe and effective treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal of Isavuconazonium Injection:

• Storage: Isavuconazonium Injection should be stored according to the manufacturer’s instructions, typically at controlled room temperature. It should be protected from light and freezing.
• Handling: Healthcare professionals should handle Isavuconazonium Injection with care to prevent accidental exposure. Proper aseptic techniques should be followed during preparation and administration to minimize contamination.
• Disposal: Unused Isavuconazonium Injection and materials used for preparation should be disposed of properly according to local regulations for hazardous waste disposal. Your healthcare provider or pharmacist can provide guidance on safe disposal practices.

In case of emergency/overdose

• Symptoms of Overdose: If an overdose of Isavuconazonium Injection is suspected, symptoms may include severe nausea, vomiting, diarrhea, or other severe adverse reactions.
• Seek Immediate Medical Attention: In case of overdose or emergency, contact your local poison control center (in the US, call 1-800-222-1222) or seek emergency medical assistance immediately. Provide as much information as possible about the medication and the amount ingested.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Always follow your healthcare provider’s instructions regarding the dosage, schedule, and administration of Isavuconazonium Injection.
• Regular Monitoring: Your healthcare provider will monitor your response to treatment and may perform tests to check liver function, kidney function, and other parameters periodically.
• Avoiding Interactions: Inform your healthcare provider about all medications you are currently taking, including prescription medications, over-the-counter drugs, vitamins, and herbal supplements, to avoid potential interactions.
• Medical Alert Bracelet: If you have a history of severe allergic reactions or other medical conditions that may require emergency treatment, consider wearing a medical alert bracelet or pendant.
• Pregnancy/Breastfeeding: Discuss with your healthcare provider the risks and benefits of Isavuconazonium Injection if you are pregnant, planning to become pregnant, or breastfeeding.
• Follow-up Care: Attend all scheduled appointments and follow-up visits as recommended by your healthcare provider to monitor your progress and manage any potential side effects.

By understanding and adhering to these guidelines, you can help ensure safe and effective treatment with Isavuconazonium Injection under the supervision of your healthcare provider. Prompt action in case of emergencies or overdose is crucial for managing potential complications effectively.