Warning

Collagenase Clostridium Histolyticum (CCH) injection is primarily used to treat Dupuytren’s contracture and Peyronie’s disease. Like all medications, it carries potential risks and side effects. Here are some of the risks associated with Collagenase Clostridium Histolyticum:

• Allergic Reactions: Some individuals may experience allergic reactions to the injection, which can range from mild itching and rash to more severe symptoms like difficulty breathing.
• Injection Site Reactions: Common side effects include swelling, bruising, pain, and itching at the injection site. These reactions are usually mild to moderate in severity.
• Tendon Rupture or Damage: In some cases, the enzyme can affect nearby tendons, leading to tendon rupture or damage. This risk is higher if the injection is not properly administered or if the affected area is strained or stressed soon after treatment.
• Nerve Injury: There is a potential risk of nerve injury, which can cause numbness, tingling, or weakness in the affected area.
• Hematoma: Sometimes, bleeding can occur at the injection site, leading to the formation of a hematoma (collection of blood outside blood vessels).
• Infection: Although rare, there is a risk of infection at the injection site. Signs of infection include increased pain, swelling, redness, or drainage from the injection site.
• Other Systemic Effects: In rare cases, Collagenase Clostridium Histolyticum can cause systemic reactions such as fever, malaise, or flu-like symptoms.

It’s essential to discuss these risks with a healthcare provider before starting treatment with Collagenase Clostridium Histolyticum. They can help assess whether the benefits outweigh the potential risks for your specific medical condition.

Why is this medication prescribed?

Collagenase Clostridium Histolyticum (CCH) injection is prescribed primarily for two conditions:

• Dupuytren’s Contracture: This condition involves the thickening and tightening of tissue under the skin of the palm and fingers, causing one or more fingers to bend into the palm and impairing hand function. CCH injection helps break down the excess collagen in the affected tissue, allowing for improved finger movement and function.
• Peyronie’s Disease: This condition is characterized by the formation of fibrous scar tissue inside the penis, causing curved or bent erections that can be painful or make sexual intercourse difficult. CCH injection is used to break down the collagen buildup in the scar tissue, potentially reducing penile curvature and improving symptoms.

How should this medicine be used?

Usage of Collagenase Clostridium Histolyticum (CCH) injection:

• Administration: The injection is administered directly into the affected tissue or scar by a healthcare professional.
• Treatment Schedule: The treatment typically involves a series of injections over several weeks, depending on the severity of the condition and the response to treatment.
• Post-Injection Care: After each injection, the affected area may be wrapped or splinted as directed by the healthcare provider to protect the area and optimize the effect of the medication.
• Monitoring: Regular follow-up visits are essential to monitor the progress of treatment and assess any adverse effects or complications.

It’s crucial to follow the healthcare provider’s instructions carefully regarding the administration and care after receiving Collagenase Clostridium Histolyticum injections. This helps ensure the treatment is effective and minimizes the risk of complications. If you have any questions or concerns about the treatment, always consult your healthcare provider for guidance.

Other uses for this medicine

Some potential other uses include:

• Ledderhose Disease: Similar to Dupuytren’s contracture but affecting the feet, causing thickened nodules in the plantar fascia.
• Cellulite: Some studies have investigated the use of CCH for breaking down collagen in cellulite.
• Adhesive Capsulitis (Frozen Shoulder): Investigational use to help improve shoulder mobility by breaking down collagen adhesions.

What special precautions should I follow?

Now, regarding special precautions for Collagenase Clostridium Histolyticum Injection:

• Allergic Reactions: Inform your healthcare provider about any allergies you have, particularly to collagenase or any other ingredients in the medication. Allergic reactions, though rare, can occur and may require immediate medical attention.
• Injection Site Care: Follow your healthcare provider’s instructions carefully regarding post-injection care. This may include using ice packs, elevating the injected area, and avoiding strenuous activities that could strain the treated area.
• Tendon and Nerve Safety: Since CCH can affect nearby tendons and nerves, it’s important to avoid excessive stress or strain on the treated area immediately after injection. Your healthcare provider will provide guidance on how to protect the area during recovery.
• Infection Risk: Monitor the injection site for signs of infection, such as increased pain, swelling, redness, or drainage. Promptly report any such symptoms to your healthcare provider.
• Systemic Effects: While uncommon, systemic reactions such as fever or malaise have been reported. If you experience any unusual symptoms after receiving the injection, inform your healthcare provider.
• Pregnancy and Breastfeeding: The safety of Collagenase Clostridium Histolyticum during pregnancy and breastfeeding has not been established. Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Collagenase Clostridium Histolyticum.

Always adhere to your healthcare provider’s instructions and attend scheduled follow-up appointments to monitor your response to treatment and address any concerns or side effects promptly.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with Collagenase Clostridium Histolyticum injection. However, maintaining a balanced diet and staying hydrated can support overall health and recovery.

What should I do if I forget a dose?

Since Collagenase Clostridium Histolyticum is administered by a healthcare professional as a series of injections, there is generally no concern about forgetting a dose in the same way you might with an oral medication. Each injection is administered as scheduled based on your treatment plan.

If you are unable to attend a scheduled injection appointment, it’s important to contact your healthcare provider as soon as possible to reschedule. Consistency in the treatment schedule is essential for achieving the desired therapeutic effect.

What side effects can this medication cause?

Collagenase Clostridium Histolyticum (CCH) injection, like any medication, can cause side effects. These side effects can vary in severity and frequency. Here are some of the potential side effects associated with Collagenase Clostridium Histolyticum:

• Common Injection Site Reactions:
  • Pain or discomfort at the injection site
  • Swelling
  • Bruising
  • Itching
  • Redness
• Tendon and Ligament Injuries:
  • Tendonitis
  • Tendon rupture (rare but serious)
  • Ligament damage
• Nerve Injuries:
  • Numbness or tingling at or near the injection site
  • Weakness
• Allergic Reactions:
  • Rash
  • Itching or hives
  • Swelling of the face, lips, tongue, or throat (which may cause difficulty breathing)
• Systemic Effects:
  • Fever
  • Malaise (feeling generally unwell)
  • Flu-like symptoms
• Hematoma: A collection of blood outside of blood vessels, which can occur at the injection site.
• Infection: Although rare, there is a risk of infection at the injection site.
• Other:
  • Headache
  • Fatigue
  • Dizziness

It’s important to note that not all individuals will experience these side effects, and their severity can vary. Some side effects may require medical attention, especially severe allergic reactions, signs of infection, or significant pain and swelling at the injection site.

If you experience any unusual symptoms or side effects after receiving Collagenase Clostridium Histolyticum injection, it’s crucial to inform your healthcare provider promptly. They can provide guidance on managing these effects and determine if any further medical intervention is necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Collagenase Clostridium Histolyticum injections are typically stored by healthcare providers or pharmacies. They should be kept in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). Protect the medication from light.
• Handling: Always handle Collagenase Clostridium Histolyticum with care to avoid accidental exposure. It should only be administered by healthcare professionals trained in its use.
• Disposal: Unused or expired Collagenase Clostridium Histolyticum should be disposed of properly according to local regulations or guidelines provided by your healthcare provider or pharmacist. Do not dispose of medications in wastewater or household waste unless specifically instructed to do so.

In case of emergency/overdose

• Emergency Situations: In case of a severe allergic reaction (anaphylaxis) or any other medical emergency after receiving Collagenase Clostridium Histolyticum injection, seek immediate medical assistance by calling emergency services (e.g., 911 in the United States) or going to the nearest emergency room.
• Overdose: Since Collagenase Clostridium Histolyticum is administered by healthcare professionals, overdose is unlikely. However, if you suspect an overdose or excessive exposure to the medication, contact your healthcare provider, Poison Control Center (1-800-222-1222 in the United States), or seek emergency medical attention.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. These visits are essential to monitor your response to treatment, assess any side effects, and adjust your treatment plan if necessary.
• Pregnancy and Breastfeeding: The safety of Collagenase Clostridium Histolyticum during pregnancy and breastfeeding has not been established. Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Informing Healthcare Providers: Always inform your healthcare provider about all medications (prescription and over-the-counter), supplements, and herbal products you are taking. Some medications or substances may interact with Collagenase Clostridium Histolyticum.
• Patient Education: Understand the purpose of Collagenase Clostridium Histolyticum treatment, potential side effects, and what to expect during and after the injection. If you have any questions or concerns, do not hesitate to discuss them with your healthcare provider.

By following these guidelines and staying informed about Collagenase Clostridium Histolyticum injection, you can help ensure safe and effective treatment for conditions such as Dupuytren’s contracture or Peyronie’s disease. Always rely on the guidance of your healthcare provider regarding the use and management of this medication.