WARNING

Camptosar, also known as Generic Irinotecan Injection, is a chemotherapy medication used primarily in the treatment of various cancers, including colorectal cancer. Like many chemotherapy drugs, it comes with several potential risks and side effects:

• Bone marrow suppression: Camptosar can reduce the production of blood cells in the bone marrow, leading to low white blood cell counts (neutropenia), low platelet counts (thrombocytopenia), and low red blood cell counts (anemia). This can increase the risk of infections, bleeding, and fatigue.
• Gastrointestinal toxicity: Common side effects include diarrhea, which can be severe and lead to dehydration and electrolyte imbalances. Other gastrointestinal issues may include nausea, vomiting, and abdominal pain.
• Liver toxicity: Camptosar can cause liver enzyme abnormalities and in severe cases, liver damage. Monitoring of liver function is typically required during treatment.
• Allergic reactions: Some individuals may experience allergic reactions ranging from mild rash to severe anaphylaxis. It’s important for healthcare providers to monitor patients closely during infusion.
• Delayed diarrhea: One of the notable side effects of Camptosar is delayed-onset diarrhea, which can occur several days after treatment. It can be severe and may require aggressive management to prevent dehydration and complications.
• Increased risk of infections: Due to its effects on white blood cell production, patients on Camptosar are more susceptible to infections. Precautions to avoid infections and prompt treatment of any infections that develop are essential.
• Other potential side effects: These may include fatigue, hair loss, mouth sores, loss of appetite, and changes in taste sensation.

Patients receiving Camptosar are closely monitored by healthcare providers to manage and mitigate these risks. The benefits of treatment with Camptosar are weighed against these potential risks based on the individual patient’s condition and cancer type.

Why is this medication prescribed?

Camptosar (Generic Irinotecan Injection) is prescribed primarily for the treatment of various cancers, most notably colorectal cancer. It is used in combination with other chemotherapy medications or alone, depending on the specific treatment plan devised by oncologists. Here are some key reasons why Camptosar may be prescribed:

• Colorectal Cancer: Camptosar is commonly used in the treatment of advanced colorectal cancer, either as a first-line treatment or in later stages when the cancer has spread (metastatic).
• Other Cancers: It may also be used for other types of cancers such as small cell lung cancer and certain types of gastrointestinal cancers.

How should this medicine be used?

How Camptosar should be used:

• Administration: Camptosar is typically administered intravenously (IV) by healthcare professionals in a clinical setting such as a hospital or outpatient clinic.
• Dosage: The dosage of Camptosar varies based on factors such as the type of cancer being treated, the patient’s overall health, and other medications being used concurrently. The specific dosage regimen will be determined by the oncologist.
• Schedule: Camptosar is often given in cycles, with a period of treatment followed by a rest period to allow the body to recover. The exact schedule of administration (frequency and duration) will be determined by the oncologist based on the individual patient’s response and tolerance to the medication.
• Monitoring: Patients receiving Camptosar require close monitoring during treatment. This includes regular blood tests to check blood cell counts, liver function tests, and monitoring for any signs of allergic reactions or severe side effects like diarrhea.
• Management of side effects: Given the potential for severe diarrhea, patients are often prescribed medications to manage and prevent diarrhea. It’s crucial for patients to communicate any side effects or concerns to their healthcare team promptly.
• Compliance: It is essential for patients to follow the prescribed treatment schedule and attend all scheduled appointments to optimize the effectiveness of the treatment and manage potential side effects effectively.

Overall, Camptosar is used as part of a comprehensive treatment plan for cancer, and its use is carefully monitored to balance therapeutic benefits with potential risks and side effects.

Other uses for this medicine

• Pancreatic Cancer: It may be used in combination with other chemotherapy drugs for the treatment of pancreatic cancer.
• Ovarian Cancer: Sometimes used in combination therapies for advanced ovarian cancer.
• Brain Tumors: In certain cases, Camptosar may be used in the treatment of brain tumors, particularly glioblastoma multiforme.

What special precautions should I follow?

When using Camptosar, several special precautions should be followed to ensure its safe and effective use:

• Medical History: Before starting Camptosar treatment, inform your healthcare provider about any medical conditions you have, especially liver disease, kidney disease, or any history of severe allergic reactions.
• Pregnancy and Breastfeeding: Camptosar can cause harm to unborn babies, so it should not be used during pregnancy unless clearly necessary. It is also not recommended during breastfeeding due to potential harm to the infant.
• Blood Counts: Regular blood tests are necessary to monitor blood cell counts (especially white blood cells and platelets) during treatment. This helps detect and manage potential bone marrow suppression.
• Liver Function: Monitoring of liver function through blood tests is important, as Camptosar can affect liver enzymes and function.
• Diarrhea Management: Due to the risk of severe diarrhea, patients are often prescribed medications (such as loperamide) to manage diarrhea during and after treatment. It’s crucial to follow your healthcare provider’s instructions for managing diarrhea and staying hydrated.
• Allergic Reactions: Inform your healthcare team immediately if you experience any signs of an allergic reaction during or after Camptosar infusion, such as rash, itching, swelling, or difficulty breathing.
• Infections: Due to the potential for lowered immune function (neutropenia), take precautions to avoid infections, such as practicing good hygiene and avoiding close contact with sick individuals.
• Other Medications: Inform your healthcare provider about all medications (including over-the-counter drugs, vitamins, and supplements) you are taking, as they may interact with Camptosar.
• Driving and Activities: Camptosar can cause fatigue and dizziness, which may impair your ability to drive or operate machinery. Exercise caution until you know how Camptosar affects you.
• Follow-up: Attend all scheduled appointments with your healthcare provider for monitoring and assessment of treatment effectiveness and any potential side effects.

Following these precautions helps ensure that Camptosar is used safely and effectively as part of your cancer treatment plan. Always communicate openly with your healthcare team about any concerns or questions you may have during your treatment.

What special dietary instructions should I follow?

• Hydration: Drink plenty of fluids to stay hydrated, especially during episodes of diarrhea or if instructed by your healthcare provider.
• Nutrition: Eat a well-balanced diet that includes foods rich in electrolytes (like potassium and sodium) to help maintain electrolyte balance. Your healthcare provider may recommend specific dietary changes based on your individual needs and side effects.

What should I do if I forget a dose?

If you miss a dose of Camptosar, it’s important to contact your healthcare provider or clinic immediately for guidance. The steps to take can vary depending on how close you are to your next scheduled dose and the specific treatment regimen. Your healthcare provider may decide to adjust your treatment schedule or dosage to ensure continuity of therapy.

What side effects can this medication cause?

Camptosar (irinotecan) is a chemotherapy medication used to treat various types of cancer, including colorectal cancer. It can cause several side effects, which can vary in severity from mild to potentially severe. Common side effects of Camptosar include:

• Digestive system issues: Diarrhea is a significant side effect, which can sometimes be severe and lead to dehydration if not managed properly. Other digestive problems may include nausea, vomiting, abdominal pain, and loss of appetite.
• Low blood cell counts: Camptosar can lower the number of white blood cells, red blood cells, and platelets in your blood, leading to increased risk of infections, anemia, and bleeding.
• Fatigue: Feeling tired or weak is a common side effect of chemotherapy, including Camptosar.
• Hair loss: Temporary hair loss is possible with Camptosar treatment.
• Mouth sores: Some people may develop sores or ulcers in the mouth or on the lips.
• Injection site reactions: If Camptosar is given intravenously, there may be reactions at the injection site such as pain, redness, or swelling.
• Allergic reactions: While rare, allergic reactions including rash, itching, swelling, dizziness, or difficulty breathing can occur.
• Other side effects: These may include muscle cramps, headache, fever, changes in taste, and changes in skin or nail color.

It’s important for patients receiving Camptosar to be closely monitored by their healthcare team for these potential side effects. Management strategies, such as medications to prevent or control diarrhea, can often help mitigate these effects and improve quality of life during treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal of Camptosar:

• Storage: Camptosar (Generic Irinotecan Injection) should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F). It should be protected from light and kept in its original packaging until ready for use.
• Handling: Camptosar is a cytotoxic medication, meaning it can be harmful if it comes into direct contact with skin or mucous membranes. Healthcare providers who handle Camptosar should use gloves and take precautions to avoid exposure.
• Disposal: Unused or expired Camptosar should be disposed of properly according to local regulations for hazardous waste disposal. Do not dispose of Camptosar in household trash. Your healthcare provider or pharmacist can provide guidance on how to safely dispose of unused medications.

In case of emergency/overdose

• Seek Immediate Medical Attention: Contact emergency medical services (911) or your local poison control center (1-800-222-1222) for advice and assistance.
• Symptom Management: If you or someone else has taken too much Camptosar or is experiencing severe side effects, medical professionals will provide supportive care and manage symptoms accordingly.
• Inform Healthcare Provider: After emergency treatment, inform your healthcare provider or oncologist about the incident. They can assess any potential complications and adjust your treatment plan as needed.

What other information should I know?

• Follow-Up Care: Attend all scheduled appointments with your healthcare provider for monitoring and assessment during and after Camptosar treatment.
• Pregnancy and Contraception: Camptosar can harm unborn babies. Use effective contraception during treatment and discuss family planning with your healthcare provider.
• Driving and Activities: Camptosar may cause fatigue or dizziness. Use caution when driving or operating machinery until you know how Camptosar affects you.
• Diet and Hydration: Stay hydrated and follow any dietary recommendations provided by your healthcare team to help manage side effects like diarrhea and maintain overall health.
• Medication Interactions: Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, to avoid interactions with Camptosar.
• Support Resources: Consider seeking support from oncology nurses, support groups, or counseling services to help manage the emotional and psychological aspects of cancer treatment.

By following these guidelines and staying informed about Camptosar, you can help ensure safe and effective treatment as part of your cancer care plan. Always communicate openly with your healthcare team about any concerns or questions you may have during your treatment journey.