Why is this medication prescribed?

Cabometyx (cabozantinib) is prescribed primarily for the treatment of two types of cancer:

• Renal Cell Carcinoma (RCC): This is the most common type of kidney cancer in adults. Cabometyx is used to treat advanced RCC, particularly in cases where the cancer has spread to other parts of the body.
• Hepatocellular Carcinoma (HCC): This is the most common type of liver cancer. Cabometyx is also approved for the treatment of advanced HCC in patients who have previously received sorafenib, another medication used to treat liver cancer.

In both types of cancer, Cabometyx works by inhibiting the activity of certain proteins that are involved in the growth and spread of cancer cells. By targeting these proteins, Cabometyx can help slow down the progression of the disease and improve outcomes for patients.

How should this medicine be used?

Cabometyx (cabozantinib) is an oral medication typically taken once daily. Here’s how it is generally used:

• Dosage: The recommended dosage of Cabometyx can vary depending on the type of cancer being treated, your body weight, and other individual factors. Your doctor will prescribe the appropriate dosage for you.
• Administration: Cabometyx is usually taken orally, in the form of tablets. You should swallow the tablets whole with a glass of water. Do not crush, chew, or break the tablets.
• Timing: Cabometyx can be taken with or without food. You should take it at the same time each day to maintain a consistent level of the medication in your body.
• Follow your doctor’s instructions: It’s crucial to follow your doctor’s instructions precisely when taking Cabometyx. Do not change your dose or stop taking the medication without consulting your doctor first, as this can affect its effectiveness and potentially lead to adverse effects.
• Monitoring: Your doctor will monitor your progress regularly while you are taking Cabometyx. This may involve blood tests and other medical assessments to check how well the medication is working and to monitor for any potential side effects.
• Side effects: Be aware of possible side effects of Cabometyx, and report any unusual symptoms to your doctor promptly. Common side effects may include diarrhea, fatigue, decreased appetite, high blood pressure, and hand-foot syndrome. Your doctor can provide guidance on managing side effects and may adjust your dosage or treatment plan as needed.
• Storage: Store Cabometyx tablets at room temperature, away from moisture and heat. Keep them in the original container with the lid tightly closed.

Always communicate openly with your healthcare team about any questions or concerns you have about taking Cabometyx. They are there to help you navigate your treatment and ensure the best possible outcome.

Other uses for this medicine

While Cabometyx (cabozantinib) is primarily prescribed for the treatment of renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC), there may be instances where it is used “off-label” for other types of cancer or conditions. However, the off-label use of Cabometyx should only be determined by your doctor based on individual circumstances and clinical judgment.

What special precautions should I follow?

Special precautions should be observed when taking Cabometyx to ensure safety and effectiveness. Here are some important considerations:

• Medical History: Before starting Cabometyx, inform your doctor about your complete medical history, including any allergies, pre-existing conditions, previous treatments, and current medications (both prescription and over-the-counter).
• Pregnancy and Breastfeeding: Cabometyx can cause harm to an unborn baby and is not recommended during pregnancy. If you are pregnant or planning to become pregnant, discuss the risks and benefits of Cabometyx with your doctor. It is also not known whether Cabometyx passes into breast milk, so breastfeeding is not recommended while taking this medication.
• Liver Function: Cabometyx may affect liver function, so your doctor may perform regular liver function tests during treatment. Inform your doctor if you have a history of liver disease or if you experience symptoms such as yellowing of the skin or eyes, dark urine, or persistent nausea.
• High Blood Pressure: Cabometyx can increase blood pressure, so your doctor will monitor your blood pressure regularly during treatment. If you have a history of high blood pressure or are currently taking medications for hypertension, it’s essential to inform your doctor.
• Wound Healing: Cabometyx may impair wound healing, so it’s important to inform your doctor if you have any scheduled surgeries or if you experience any unusual or persistent wound healing issues during treatment.
• Thyroid Function: Cabometyx can affect thyroid function, leading to symptoms such as fatigue, weight changes, and changes in mood. Your doctor may monitor your thyroid function and may prescribe thyroid replacement therapy if necessary.
• Bone Health: Cabometyx may cause bone-related side effects, such as bone pain or fractures. Your doctor may recommend measures to support bone health, such as calcium and vitamin D supplements or medications to prevent bone loss.
• Driving and Machinery: Cabometyx may cause fatigue or dizziness, which can impair your ability to drive or operate machinery. Use caution when engaging in activities that require alertness until you know how Cabometyx affects you.

Always follow your doctor’s instructions and guidance when taking Cabometyx, and don’t hesitate to ask any questions or express any concerns you may have about your treatment. Your healthcare team is there to support you throughout your treatment journey.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Cabometyx. However, maintaining a balanced and nutritious diet can support overall health during cancer treatment. Your doctor or a registered dietitian may provide personalized dietary advice based on your individual needs and treatment regimen.

What should I do if I forget a dose?

If you forget to take a dose of Cabometyx, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and take your next dose at the regular time. Do not take a double dose to make up for a missed one. If you have any concerns about missed doses or need further guidance, consult your doctor or healthcare provider.

What side effects can this medication cause?

Cabometyx (cabozantinib) can cause a variety of side effects, which can vary in severity from person to person. Some common side effects include:

• Fatigue: Feeling tired or weak is a common side effect of Cabometyx.
• Diarrhea: Cabometyx can cause diarrhea, which may be mild to severe.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting while taking Cabometyx.
• Decreased Appetite: Cabometyx may reduce appetite in some patients.
• High Blood Pressure (Hypertension): Cabometyx can increase blood pressure. Regular monitoring of blood pressure is typically recommended during treatment.
• Hand-Foot Syndrome: This condition can cause redness, swelling, pain, or blisters on the palms of the hands and/or the soles of the feet.
• Weight Loss: Some individuals may experience weight loss while taking Cabometyx.
• Proteinuria: Cabometyx may cause increased levels of protein in the urine.
• Hair Color Changes: Cabometyx may cause changes in hair color, typically turning it lighter.
• Changes in Taste: Some individuals may experience alterations in taste perception while taking Cabometyx.
• Muscle Pain and Weakness: Cabometyx can cause muscle pain and weakness.
• Headache: Headaches are a common side effect of Cabometyx.
• Difficulty Breathing: Some individuals may experience difficulty breathing while taking Cabometyx.
• Abdominal Pain: Cabometyx may cause abdominal pain or discomfort.
• Joint Pain: Joint pain is another potential side effect of Cabometyx.

It’s essential to report any side effects to your healthcare provider, as they can provide guidance on managing symptoms and may adjust your treatment regimen if necessary. Additionally, some side effects may require immediate medical attention, so it’s important to seek help if you experience severe or concerning symptoms while taking Cabometyx.

What should I know about storage and disposal of this medication?

Storage and disposal of Cabometyx:

• Storage: Store Cabometyx tablets at room temperature, away from moisture and heat. Keep them in the original container with the lid tightly closed.
• Disposal: Dispose of any unused or expired Cabometyx tablets properly according to local regulations or guidelines. Do not flush them down the toilet or pour them down the drain unless instructed to do so. Instead, consult your pharmacist or local waste disposal facility for proper disposal instructions.

In case of emergency/overdose

• Seek Medical Help: If you suspect an overdose or experience severe symptoms such as difficulty breathing, severe dizziness, fainting, or loss of consciousness, seek immediate medical attention by calling emergency services or going to the nearest emergency room.
• Poison Control Center: You can also contact your local poison control center for guidance on what to do in case of an overdose. They can provide information on potential symptoms and advise on the appropriate steps to take.

What other information should I know?

• Regular Monitoring: Your doctor will monitor your progress regularly while taking Cabometyx. This may involve blood tests, imaging tests, and other medical assessments to check how well the medication is working and to monitor for any potential side effects.
• Follow-up Appointments: Attend all scheduled follow-up appointments with your doctor to assess your response to treatment and make any necessary adjustments to your treatment plan.
• Patient Assistance Programs: Some pharmaceutical companies offer patient assistance programs to help individuals afford their medications, including Cabometyx. If you’re having trouble paying for your medication, ask your healthcare provider or pharmacist about available assistance programs.
• Drug Interactions: Inform your doctor about all medications, supplements, and herbal products you are taking, as Cabometyx may interact with other drugs. Your doctor can advise you on potential interactions and adjust your treatment regimen accordingly.
• Pregnancy and Breastfeeding: Cabometyx can cause harm to an unborn baby and is not recommended during pregnancy. If you are pregnant or planning to become pregnant, discuss the risks and benefits of Cabometyx with your doctor. It is also not known whether Cabometyx passes into breast milk, so breastfeeding is not recommended while taking this medication.
• Driving and Machinery: Cabometyx may cause fatigue or dizziness, which can impair your ability to drive or operate machinery. Use caution when engaging in activities that require alertness until you know how Cabometyx affects you.

Always follow your doctor’s instructions and guidance when taking Cabometyx, and don’t hesitate to ask any questions or express any concerns you may have about your treatment. Your healthcare team is there to support you throughout your treatment journey.