WARNING

Brintellix, also known as vortioxetine, is a medication primarily used to treat major depressive disorder. Like any medication, it comes with potential risks and side effects. Here’s a brief overview of some common risks associated with taking Brintellix:

• Side Effects: Brintellix can cause side effects such as nausea, vomiting, diarrhea, constipation, dizziness, and sexual dysfunction. These side effects can vary in severity and may impact individuals differently.
• Serotonin Syndrome: Brintellix affects serotonin levels in the brain. In rare cases, it can lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as confusion, rapid heart rate, high blood pressure, fever, sweating, tremors, and seizures.
• Withdrawal Symptoms: Abruptly stopping Brintellix can lead to withdrawal symptoms such as headache, dizziness, nausea, fatigue, irritability, and flu-like symptoms. It’s important to gradually taper off the medication under medical supervision to minimize these effects.
• Increased Suicide Risk: Like many antidepressants, Brintellix may initially increase the risk of suicidal thoughts or behaviors, especially in young adults under 25. Patients should be closely monitored, especially when starting the medication or adjusting the dosage.
• Interactions with Other Medications: Brintellix can interact with other medications, including other antidepressants, migraine medications, and certain supplements. These interactions can increase the risk of side effects or reduce the effectiveness of either medication.
• Bleeding Risk: Brintellix may increase the risk of bleeding, especially when used with other medications that also affect bleeding, such as blood thinners or nonsteroidal anti-inflammatory drugs (NSAIDs).

It’s essential for individuals considering Brintellix to discuss the potential risks and benefits with their healthcare provider. They can provide personalized guidance based on the individual’s medical history and current medications to help make an informed decision.

Why is this medication prescribed?

Brintellix, also known by its generic name vortioxetine, is prescribed primarily for the treatment of major depressive disorder (MDD) in adults. It belongs to a class of medications called serotonin reuptake inhibitors and receptor modulators (SSRIs/SNRIs), which work by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter involved in regulating mood, emotions, and behavior.

How should this medicine be used?

Here’s how Brintellix is typically used:

• Dosage: The usual starting dose of Brintellix for adults is 10 milligrams (mg) once daily. Your healthcare provider may adjust the dosage based on your response to the medication and any side effects experienced. The maximum recommended dose is 20 mg per day.
• Administration: Brintellix is usually taken orally, with or without food. It’s essential to take the medication exactly as prescribed by your healthcare provider. Do not take more or less than the prescribed dose, and do not stop taking Brintellix abruptly without consulting your doctor.
• Duration of Treatment: The duration of treatment with Brintellix varies depending on the individual’s response to the medication. It may take several weeks for the full therapeutic effect to be achieved. Your healthcare provider will monitor your progress and adjust the treatment plan as needed.
• Missed Dose: If you miss a dose of Brintellix, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
• Discontinuation: If you and your healthcare provider decide to stop treatment with Brintellix, it’s important to gradually taper off the medication under medical supervision to minimize the risk of withdrawal symptoms.
• Monitoring: Your healthcare provider will monitor your response to Brintellix regularly, especially during the initial weeks of treatment. They may also conduct periodic assessments to evaluate the need for continued treatment.

It’s crucial to follow your healthcare provider’s instructions carefully when using Brintellix to ensure its safe and effective use in treating major depressive disorder. If you have any questions or concerns about your medication regimen, don’t hesitate to discuss them with your healthcare provider.

Other uses for this medicine

Buprenorphine injection is primarily used for opioid addiction treatment and pain management, but it may also be used off-label for other purposes under the guidance of a healthcare professional. Off-label uses may include managing certain types of chronic pain or as part of anesthesia for surgical procedures.

What special precautions should I follow?

Regarding precautions for Brintellix, it’s crucial to follow your healthcare provider’s guidance closely. Here are some general precautions:

• Medical History: Inform your doctor about your medical history, especially regarding any past or present psychiatric conditions, liver problems, seizures, or bleeding disorders.
• Drug Interactions: Brintellix may interact with other medications or supplements, including certain antidepressants, migraine medications, and blood thinners. Make sure your doctor is aware of all the medications you’re taking.
• Pregnancy and Breastfeeding: If you’re pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of taking Brintellix with your doctor. It’s essential to weigh the potential risks to the fetus or infant against the benefits of treatment.
• Suicidal Thoughts: Like many antidepressants, Brintellix may increase the risk of suicidal thoughts, especially in young adults. Be vigilant for any changes in mood or behavior and report them to your doctor immediately.
• Side Effects: Be aware of potential side effects such as nausea, diarrhea, dry mouth, dizziness, and sexual dysfunction. If you experience any severe or persistent side effects, inform your doctor promptly.
• Dosage: Take Brintellix exactly as prescribed by your doctor. Do not increase or decrease the dosage without consulting your healthcare provider.
• Alcohol and Other Substances: Avoid alcohol and recreational drugs while taking Brintellix, as they can worsen side effects and potentially interact with the medication.

Always remember to attend regular follow-up appointments with your doctor to monitor your progress and discuss any concerns or changes in your condition.

What special dietary instructions should I follow?

As for special dietary instructions, there aren’t specific dietary restrictions associated with taking Brintellix. However, maintaining a healthy, balanced diet can support your overall well-being and complement your treatment for depression or other conditions.

What should I do if I forget a dose?

If you forget to take a dose of Brintellix, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Brintellix (vortioxetine) can cause various side effects, though not everyone will experience them. Common side effects may include:

• Nausea: Feeling sick to your stomach or the urge to vomit.
• Diarrhea: Frequent loose or watery bowel movements.
• Dry Mouth: A lack of moisture in the mouth, often accompanied by thirst.
• Dizziness: Feeling lightheaded or unsteady.
• Headache: Aching or discomfort in the head.
• Insomnia: Difficulty falling asleep or staying asleep.
• Sexual Dysfunction: Problems with sexual desire, arousal, or performance.
• Fatigue: Feeling tired or lacking energy.
• Constipation: Difficulty passing stool, often with infrequent bowel movements.
• Sweating: Increased perspiration, especially at night.

Less common but potentially more serious side effects of Brintellix may include:

• Serotonin Syndrome: A potentially life-threatening condition characterized by high levels of serotonin in the body, which can cause symptoms such as agitation, hallucinations, rapid heartbeat, high blood pressure, fever, excessive sweating, shivering, tremors, muscle twitching, and in severe cases, loss of consciousness or seizures. This is rare but requires immediate medical attention if suspected.
• Suicidal Thoughts or Behavior: Antidepressants like Brintellix may increase the risk of suicidal thoughts or behavior, particularly in children, adolescents, and young adults. Close monitoring by a healthcare professional is essential, especially at the beginning of treatment or when the dosage is adjusted.
• Bleeding: Brintellix may increase the risk of bleeding, especially when taken with other medications that also increase bleeding risk, such as blood thinners. Inform your doctor if you notice any unusual bleeding or bruising.
• Hyponatremia: A potentially dangerous drop in sodium levels in the blood, which can cause symptoms like headache, confusion, weakness, seizures, and coma. Seek medical attention if you experience these symptoms.

It’s important to report any side effects you experience while taking Brintellix to your healthcare provider. They can help assess the severity of the side effects and determine whether any adjustments to your treatment are necessary.

What should I know about storage and disposal of this medication?

Here’s what you should know about storage and disposal of Brintellix:

• Storage: Store Brintellix tablets at room temperature away from light and moisture. Avoid storing them in the bathroom or near the kitchen sink. Keep the medication out of reach of children and pets.
• Disposal: Dispose of unused or expired Brintellix tablets properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so. Instead, consult your pharmacist or local waste disposal company for guidance on how to safely dispose of medications.

In case of emergency/overdose

• Seek Medical Attention: If you or someone else has overdosed on Brintellix or is experiencing severe symptoms such as loss of consciousness, seizures, difficulty breathing, or irregular heartbeat, call emergency services immediately.
• Poison Control: You can also contact your local poison control center or the National Poison Control hotline (1-800-222-1222 in the United States) for guidance on what to do next.

What other information should I know?

• Follow Instructions: Take Brintellix exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider.
• Regular Monitoring: Attend regular follow-up appointments with your doctor to monitor your progress and discuss any concerns or changes in your condition.
• Avoid Alcohol and Drugs: Avoid alcohol and recreational drugs while taking Brintellix, as they can worsen side effects and potentially interact with the medication.
• Driving and Operating Machinery: Brintellix may cause dizziness or drowsiness in some people. Use caution when driving or operating machinery until you know how the medication affects you.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care that you are taking Brintellix, including dentists and emergency medical personnel.
• Patient Education: Educate yourself about Brintellix, including its uses, side effects, and precautions. Ask your doctor or pharmacist if you have any questions or concerns.

By following these guidelines and staying informed about Brintellix, you can use the medication safely and effectively as part of your treatment plan.