Why is this medication prescribed?

Bendamustine injection is typically prescribed for the treatment of certain types of cancer, including chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). It belongs to a class of medications called alkylating agents, which work by interfering with the growth and spread of cancer cells in the body.

How should this medicine be used?

The specific dosage and administration of bendamustine injection depend on factors such as the type of cancer being treated, the patient’s overall health, and other medications they may be taking. Typically, it is administered intravenously (IV) by a healthcare professional in a hospital or clinic setting.

The dosage and frequency of bendamustine injections are determined by the prescribing doctor based on the individual patient’s condition. It’s essential to follow the doctor’s instructions carefully and attend all scheduled appointments for treatment.

Before starting bendamustine treatment, patients should discuss any existing medical conditions and medications with their healthcare provider to ensure the safe and effective use of this medication. Additionally, they should report any side effects or concerns experienced during treatment promptly.

Other uses for this medicine

Some off-label uses of bendamustine injection may include:

• Multiple myeloma: Bendamustine may be used in combination with other medications to treat multiple myeloma, a type of cancer that affects plasma cells in the bone marrow.
• Hodgkin’s lymphoma: It may be used as part of a chemotherapy regimen for Hodgkin’s lymphoma, a cancer of the lymphatic system.
• Soft tissue sarcoma: Bendamustine may be used off-label in the treatment of certain types of soft tissue sarcoma, although its efficacy in this context is still being studied.
• Chronic myeloid leukemia (CML): In some cases, bendamustine may be used off-label in the treatment of chronic myeloid leukemia, a type of cancer that affects the blood and bone marrow.

What special precautions should I follow?

As for special precautions when using bendamustine injection, several key considerations include:

• Pregnancy and breastfeeding: Bendamustine may cause harm to a developing fetus, so it is not recommended during pregnancy. Similarly, it may pass into breast milk and could harm a nursing infant.
• Bone marrow suppression: Bendamustine can suppress bone marrow function, leading to low blood cell counts (anemia, neutropenia, and thrombocytopenia). Regular blood tests are necessary to monitor blood cell counts during treatment.
• Infections: Patients receiving bendamustine may be at increased risk of infections due to suppressed immune function. Precautions to avoid infections, such as frequent hand washing and avoiding contact with sick individuals, are important.
• Liver and kidney function: Bendamustine is metabolized by the liver and excreted by the kidneys. Patients with impaired liver or kidney function may require dose adjustments or closer monitoring during treatment.
• Allergic reactions: Some patients may experience allergic reactions to bendamustine, which can be severe. Signs of an allergic reaction include rash, itching, swelling, dizziness, or difficulty breathing. Prompt medical attention is necessary if an allergic reaction occurs.
• Other medications: Patients should inform their healthcare provider about all medications, supplements, and herbal remedies they are taking, as some may interact with bendamustine and affect its effectiveness or increase the risk of side effects.

Overall, bendamustine should be used with caution and under the supervision of a qualified healthcare professional who can monitor for potential complications and adjust treatment as needed.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with bendamustine injection. However, it is essential to maintain a balanced diet and stay hydrated during treatment to support overall health and well-being. If you have any concerns about your diet or nutritional needs during treatment, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget a dose of bendamustine injection, it is crucial to contact your healthcare provider or treatment team for guidance. Do not try to make up for the missed dose by taking extra medication unless instructed to do so by your healthcare provider. They will advise you on the appropriate course of action based on your treatment schedule and medical condition. It’s important to adhere to the prescribed dosing schedule as closely as possible to ensure the effectiveness of the medication.

What side effects can this medication cause?

Bendamustine injection, like many chemotherapy medications, can cause various side effects. It’s essential to understand that not all individuals will experience these side effects, and the severity can vary from person to person. Common side effects of bendamustine injection may include:

• Nausea and vomiting: These symptoms are common during chemotherapy treatment. Your healthcare provider can prescribe medications to help manage nausea and vomiting.
• Fatigue: Feeling tired or weak is a common side effect of chemotherapy. It’s essential to get plenty of rest and conserve your energy during treatment.
• Low blood cell counts: Bendamustine can cause bone marrow suppression, leading to low levels of red blood cells (anemia), white blood cells (neutropenia), and platelets (thrombocytopenia). This can increase the risk of infection, bleeding, and fatigue.
• Hair loss: Some individuals may experience hair thinning or hair loss while receiving bendamustine treatment. Hair loss is usually temporary and will grow back after treatment ends.
• Injection site reactions: Pain, redness, or swelling at the injection site may occur with bendamustine injection. These symptoms are typically mild and resolve on their own.
• Increased risk of infections: Due to the suppression of the immune system, patients receiving bendamustine may be more susceptible to infections. It’s important to take precautions to avoid exposure to infectious agents and to report any signs of infection to your healthcare provider promptly.
• Numbness or tingling in the hands or feet (peripheral neuropathy): This side effect may occur with bendamustine treatment and can cause sensations of numbness, tingling, or pain in the hands and feet.
• Digestive issues: Diarrhea, constipation, and abdominal pain are possible side effects of bendamustine treatment.
• Allergic reactions: Some individuals may experience allergic reactions to bendamustine, which can be severe. Signs of an allergic reaction include rash, itching, swelling, dizziness, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.
• Liver toxicity: Bendamustine can affect liver function in some patients, leading to elevated liver enzymes. Your healthcare provider will monitor your liver function regularly during treatment.

These are not all possible side effects of bendamustine injection. Some individuals may experience other side effects not listed here. It’s essential to communicate any concerns or symptoms you experience during treatment with your healthcare provider, as they can provide guidance and support to manage side effects effectively.

What should I know about storage and disposal of this medication?

Storage and disposal of Benralizumab injection:

• Storage: Bendamustine injection should be stored at room temperature, away from light and moisture. Do not freeze the medication. Keep it out of reach of children and pets. Follow any specific storage instructions provided by your healthcare provider or pharmacist.
• Disposal: Unused or expired bendamustine injection should be disposed of properly according to local regulations. Do not dispose of it in household trash or flush it down the toilet unless instructed to do so by your healthcare provider or pharmacist. Instead, consult your local pharmacy, healthcare facility, or waste disposal authority for guidance on safe disposal methods.

In case of emergency/overdose

In case of emergency or overdose of bendamustine injection, it’s essential to seek immediate medical attention. Symptoms of overdose may include severe nausea, vomiting, diarrhea, fever, chills, or signs of allergic reaction. Contact your healthcare provider, local emergency services, or go to the nearest emergency room for evaluation and treatment.

What other information should I know?

• Follow-up appointments: Attend all scheduled appointments with your healthcare provider for blood tests and monitoring during treatment. These appointments are essential for assessing your response to treatment and managing any side effects or complications.
• Avoid live vaccines: During bendamustine treatment, avoid receiving live vaccines, as they may pose a risk of infection. Discuss vaccination schedules and recommendations with your healthcare provider before starting treatment.
• Inform healthcare providers: Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are receiving bendamustine treatment. They should be aware of your medication regimen to provide appropriate care and avoid potential drug interactions or complications.
• Patient support resources: Consider seeking support from patient advocacy groups, support groups, or counseling services to help cope with the emotional and practical challenges of cancer treatment. Your healthcare provider or local cancer center may be able to provide information about available resources.
• Medication adherence: Take bendamustine injection exactly as prescribed by your healthcare provider. Do not change the dosage or frequency of administration without consulting them first. If you have any questions or concerns about your treatment regimen, discuss them with your healthcare provider.

By following these guidelines and staying informed about bendamustine injection treatment, you can help ensure its safe and effective use as part of your cancer therapy.