Why is this medication prescribed?

Belimumab injection, sold under the brand name Benlysta, is prescribed for the treatment of systemic lupus erythematosus (SLE), commonly referred to as lupus. Lupus is an autoimmune disease where the immune system mistakenly attacks healthy tissues in various parts of the body, leading to inflammation, pain, and organ damage. Belimumab works by inhibiting a protein called B-lymphocyte stimulator (BLyS), which is involved in the activation of B cells, a type of immune cell that plays a role in the development of lupus.

Belimumab is typically prescribed for adults with active, autoantibody-positive SLE who are receiving standard therapy but continue to experience symptoms such as joint pain, fatigue, skin rashes, and inflammation affecting internal organs. It is usually used in combination with other lupus medications and is not intended for use in patients with severe active lupus nephritis or severe active central nervous system lupus.

How should this medicine be used?

Belimumab injection is typically administered intravenously (into a vein) by a healthcare professional. Here’s a general guideline on how belimumab injection is commonly used:

• Dosage: The dosage of belimumab injection is determined by factors such as the patient’s weight and response to treatment. The standard dosage for adults is typically 10 mg per kilogram (kg) of body weight, administered over a period of one hour. The dosage may be adjusted based on individual response to treatment.
• Administration: Belimumab injection is given intravenously, usually through a needle inserted into a vein in the arm. It is typically administered in a healthcare setting such as a hospital, clinic, or infusion center by trained medical personnel.
• Frequency: The frequency of belimumab injections depends on the treatment regimen prescribed by the healthcare provider. In general, belimumab is given once a week for the first three doses, then once every four weeks thereafter. It’s important to adhere to the prescribed dosing schedule and not miss any doses unless instructed by your healthcare provider.
• Monitoring: During belimumab treatment, your healthcare provider may monitor you closely for any signs of improvement in lupus symptoms or any potential side effects or adverse reactions. Regular follow-up appointments may be scheduled to assess your response to treatment and adjust the dosage or frequency of injections if necessary.
• Duration of treatment: The duration of belimumab treatment may vary depending on individual response and disease activity. Some patients may experience significant improvement in symptoms with belimumab and continue treatment long-term, while others may require additional therapies or adjustments to their treatment regimen.

It’s important to follow your healthcare provider’s instructions and guidance regarding the use of belimumab injection. They will provide specific recommendations tailored to your individual needs and monitor you closely throughout the course of treatment to ensure its effectiveness and safety. If you have any questions or concerns about belimumab injection or its administration, don’t hesitate to discuss them with your healthcare provider.

Other uses for this medicine

Belimumab (Benlysta) is primarily used for the treatment of systemic lupus erythematosus (SLE), as I mentioned earlier. However, it’s important to note that it is not approved for use in other conditions.

What special precautions should I follow?

Regarding special precautions for Belimumab injection, here are some important points to consider:

• Allergies: Inform your healthcare provider if you have any allergies to belimumab or any other medications.
• Infections: Belimumab can increase the risk of infections, including serious infections. Before starting treatment, inform your healthcare provider if you have any existing infections or a history of recurrent infections. During treatment, report any signs of infection promptly.
• Vaccinations: Avoid live vaccines while receiving belimumab treatment. Speak to your healthcare provider about appropriate vaccination schedules.
• Pregnancy and breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of belimumab during pregnancy and breastfeeding is not well-established, so your healthcare provider will weigh the potential risks and benefits.
• Interactions with other medications: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some medications may interact with belimumab, affecting its effectiveness or increasing the risk of side effects.
• Monitoring: Your healthcare provider may need to monitor you closely during belimumab treatment, including regular blood tests to check for signs of infection or other side effects.
• Hypersensitivity reactions: Belimumab can sometimes cause hypersensitivity reactions, including anaphylaxis. Seek medical attention immediately if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe itching.
• Liver function: Belimumab may affect liver function, so your healthcare provider may monitor your liver enzymes during treatment.

Always follow your healthcare provider’s instructions and guidance regarding the use of belimumab injection, and don’t hesitate to ask any questions or raise any concerns you may have about your treatment.

What special dietary instructions should I follow?

Regarding special dietary instructions for Belimumab Injection, there aren’t specific dietary restrictions associated with belimumab. However, maintaining a balanced and healthy diet can support overall health and well-being, which can be beneficial for managing lupus and other conditions.

What should I do if I forget a dose?

If you forget a dose of Belimumab Injection, contact your healthcare provider for guidance. They may advise you on the appropriate course of action, such as rescheduling the missed dose or adjusting your dosing schedule. It’s essential to follow their instructions closely to ensure the effectiveness of your treatment. Avoid doubling up on doses unless specifically instructed by your healthcare provider.

What side effects can this medication cause?

Belimumab (Benlysta) may cause side effects in some individuals. Common side effects include:

• Nausea and vomiting: Some people may experience nausea or vomiting after receiving belimumab injection.
• Diarrhea: Diarrhea is another common side effect that may occur with belimumab treatment.
• Fever: Belimumab can sometimes cause fever or an elevated body temperature.
• Headache: Headaches are a common side effect reported by some individuals receiving belimumab.
• Fatigue: Feeling tired or fatigued may occur as a side effect of belimumab treatment.
• Injection site reactions: Pain, redness, or swelling at the injection site may occur.
• Upper respiratory tract infections: Some individuals may experience upper respiratory tract infections, such as colds or sinus infections, while receiving belimumab.
• Allergic reactions: Although rare, belimumab can cause allergic reactions, including anaphylaxis. Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe itching.
• Depression: In some cases, belimumab may worsen or trigger depression or mood changes.
• Decreased white blood cell count: Belimumab may reduce the number of white blood cells in the body, increasing the risk of infections.

It’s essential to discuss any concerns about potential side effects with your healthcare provider before starting belimumab treatment. They can provide personalized guidance and monitor you for any adverse reactions during treatment. If you experience severe or persistent side effects, contact your healthcare provider promptly.

What should I know about storage and disposal of this medication?

Storage and disposal of Belimumab Injection:

• Storage: Belimumab injection should be stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). Do not freeze the medication. Protect the vials from light by keeping them in the original carton until use. Avoid storing belimumab in the refrigerator door or near the freezer compartment, as temperature fluctuations may occur.
• Disposal: Properly dispose of any unused or expired belimumab injection according to local regulations or guidelines provided by your healthcare provider or pharmacist. Do not dispose of medications in household trash or wastewater unless instructed to do so.

In case of emergency/overdose

In case of emergency or overdose of belimumab injection, seek immediate medical attention or contact a poison control center. Symptoms of overdose may include severe allergic reactions, worsening side effects, or other adverse reactions. It’s essential to follow your healthcare provider’s instructions regarding the administration of belimumab and report any concerns or adverse events promptly.

What other information should I know?

• Monitoring: Your healthcare provider may monitor you regularly during belimumab treatment, including blood tests to check for signs of infection or other side effects.
• Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to assess your response to belimumab treatment and address any concerns or questions you may have.
• Support resources: Seek support from healthcare professionals, support groups, or patient advocacy organizations for additional information, guidance, and emotional support related to living with lupus and managing your treatment.
• Keep records: Keep a record of your belimumab injections, including dates, dosages, and any side effects or symptoms experienced. This information can be helpful for discussions with your healthcare provider and tracking your treatment progress.

Always follow your healthcare provider’s instructions and guidance regarding the use of belimumab injection, and do not hesitate to reach out if you have any questions or concerns about your treatment.