Why is this medication prescribed?

Bavencio (avelumab) is a prescription medication used to treat certain types of cancer. It belongs to a class of drugs known as immune checkpoint inhibitors, which work by helping the immune system recognize and attack cancer cells.

Bavencio is typically prescribed for the following conditions:

• Merkel cell carcinoma (MCC): Bavencio is used for the treatment of adults and pediatric patients 12 years and older with metastatic MCC, a rare and aggressive type of skin cancer.
• Urothelial carcinoma: Bavencio may be used to treat locally advanced or metastatic urothelial carcinoma, which is cancer of the bladder or urinary tract.
• Renal cell carcinoma (RCC): It may also be prescribed for advanced renal cell carcinoma, a type of kidney cancer.

How should this medicine be used?

Bavencio (avelumab) is typically administered intravenously (IV), meaning it’s given directly into a vein. Here’s a general overview of how Bavencio is typically used:

• Administration: Bavencio is given by a healthcare professional in a clinic or hospital setting. It is not taken orally as a pill or capsule.
• Dosage: The dosage of Bavencio and the frequency of administration can vary depending on factors such as the type of cancer being treated, the patient’s weight, overall health, and individual response to the medication. Your doctor will determine the appropriate dosage for you.
• Frequency: Bavencio is usually administered every 2 weeks. However, the specific dosing schedule may vary based on your treatment plan.
• Duration of Treatment: Treatment with Bavencio may continue for as long as it is providing clinical benefit or until unacceptable toxicity occurs.
• Monitoring: During treatment with Bavencio, your healthcare provider will monitor you closely for any signs of side effects or adverse reactions. They may also perform regular tests to assess the response to treatment and adjust the dosage or frequency of administration as needed.
• Precautions: Before starting treatment with Bavencio, it’s important to inform your healthcare provider about any other medications you are taking, as well as any medical conditions you have. This will help ensure that Bavencio is safe and appropriate for you.
• Side Effects: Like all medications, Bavencio can cause side effects. Common side effects may include fatigue, nausea, diarrhea, rash, and infusion-related reactions. Be sure to report any side effects or concerns to your healthcare provider.

It’s essential to follow your doctor’s instructions carefully regarding the use of Bavencio. If you have any questions or concerns about your treatment, don’t hesitate to discuss them with your healthcare provider. They can provide you with personalized guidance and support throughout your treatment journey.

Other uses for this medicine

Bavencio (avelumab) is primarily used for the treatment of certain types of cancer, including Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. However, like many medications, there may be off-label uses that are not officially approved by regulatory agencies but are prescribed by healthcare providers based on clinical judgment and research findings.

What special precautions should I follow?

As for special precautions to follow when using Bavencio, here are some important considerations:

• Inform your healthcare provider: Before starting treatment with Bavencio, inform your doctor about all other medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. This is important to avoid potential drug interactions.
• Medical history: Provide your doctor with a detailed medical history, including any previous treatments for cancer, autoimmune diseases, organ transplantation, or immune system disorders. Bavencio may not be suitable for individuals with certain medical conditions.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Bavencio with your doctor. It’s essential to weigh the potential risks to the fetus or nursing infant against the benefits of treatment.
• Infusion reactions: Bavencio is administered intravenously, and infusion-related reactions, such as fever, chills, flushing, rash, or difficulty breathing, can occur. Your healthcare provider will monitor you closely during the infusion and may provide premedication to reduce the risk of these reactions.
• Immune-related adverse events: Bavencio works by stimulating the immune system, which can lead to immune-related adverse events, such as pneumonitis, colitis, hepatitis, endocrinopathies, and dermatologic reactions. Report any new or worsening symptoms to your doctor promptly.
• Regular monitoring: Your healthcare provider will monitor you closely for any signs of side effects or complications during treatment with Bavencio. This may involve regular blood tests, imaging studies, and clinical assessments.
• Follow-up care: Attend all scheduled appointments with your healthcare provider and follow their recommendations for follow-up care, including any additional treatments or supportive therapies that may be needed.

Always follow your doctor’s instructions carefully and communicate openly about any concerns or questions you may have regarding Bavencio treatment. Your healthcare team is there to support you throughout your treatment journey.

What special dietary instructions should I follow?

As for special dietary instructions, there are no specific dietary restrictions associated with Bavencio. However, maintaining a healthy and balanced diet can support overall health and well-being during cancer treatment. If you have any dietary concerns or specific dietary needs, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget a dose of Bavencio, contact your healthcare provider or treatment team as soon as possible for guidance. They can advise you on the best course of action, which may include rescheduling the missed dose or adjusting your treatment schedule. It’s important not to double up on doses unless instructed to do so by your healthcare provider.

What side effects can this medication cause?

Bavencio (avelumab) can cause a range of side effects, some of which may be serious. It’s important to be aware of these potential side effects and to promptly report any new or worsening symptoms to your healthcare provider. Common side effects of Bavencio include:

• Fatigue: Feeling tired or weak is a common side effect of Bavencio treatment.
• Nausea and vomiting: Some people may experience nausea and vomiting during treatment with Bavencio.
• Diarrhea: Diarrhea is another common side effect that may occur with Bavencio.
• Rash: Skin rash or itching may occur as a side effect of Bavencio.
• Infusion-related reactions: These reactions can occur during or shortly after the infusion of Bavencio and may include symptoms such as fever, chills, flushing, rash, or difficulty breathing.
• Decreased appetite: Some people may experience a decrease in appetite while receiving Bavencio treatment.
• Muscle or joint pain: Pain or discomfort in the muscles or joints may occur as a side effect of Bavencio.
• Fever: Fever is another possible side effect of Bavencio treatment.
• Headache: Some people may experience headaches during treatment with Bavencio.
• Changes in blood tests: Bavencio can affect certain blood tests, including tests that measure liver function, kidney function, and blood cell counts.

In addition to these common side effects, Bavencio can also cause more serious side effects, including immune-related adverse events such as pneumonitis (inflammation of the lungs), colitis (inflammation of the colon), hepatitis (inflammation of the liver), endocrinopathies (disorders of the endocrine glands), and dermatologic reactions. These serious side effects require prompt medical attention.

It’s essential to discuss any concerns or questions about side effects with your healthcare provider before starting treatment with Bavencio. They can provide guidance on how to manage side effects and monitor your health during treatment.

What should I know about storage and disposal of this medication?

Storage and disposal of Bavencio:

• Storage: Bavencio is typically stored by healthcare providers or pharmacies. However, if you have Bavencio at home, it should be stored according to the instructions provided by your healthcare provider or pharmacist. Generally, Bavencio should be stored at room temperature away from light and moisture. Do not freeze Bavencio.
• Disposal: Any unused Bavencio or materials used to prepare and administer the medication should be disposed of properly. Your healthcare provider or pharmacist can provide guidance on how to dispose of Bavencio safely. This may involve returning unused medication to the pharmacy or following specific disposal instructions provided by your healthcare provider.

In case of emergency/overdose

In case of an emergency or suspected overdose with Bavencio, seek medical attention immediately. Contact your healthcare provider, local emergency services, or go to the nearest emergency room. It’s important to report any symptoms or concerns to healthcare professionals promptly.

What other information should I know?

• Follow all instructions provided by your healthcare provider for the preparation, administration, and monitoring of Bavencio.
• Keep all appointments for follow-up visits and laboratory tests as recommended by your healthcare provider.
• Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.
• Report any new or worsening symptoms to your healthcare provider promptly, as they may be signs of side effects or complications.
• Be aware of the potential risks and benefits of Bavencio treatment, and discuss any concerns or questions with your healthcare provider.

It’s important to communicate openly with your healthcare provider throughout your treatment with Bavencio. They can provide personalized guidance and support to help ensure the safe and effective use of the medication.