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Zoladex (Goserelin) – 10.8mg Depot Syringe

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Goserelin injection

What are goserelin
GOSERELIN (Zoladex® 3.6 mg Implant, Zoladex® 3-month Implant) is a man-made protein that is
like a hormone in the body called gonadotropin-releasing
hormone (GnRH). Regular injections of goserelin decrease the levels of testosterone in men and
estrogen in women. Goserelin can be used for the
relief of endometriosis, or for the treatment of prostate cancer and breast
cancer. Women receive the Zoladex® 3.6 mg implant
only, and injections are given every 4 weeks. Men may receive the Zoladex® 3.6 mg implant every 4 weeks, or may receive a
Zoladex® 3-month implant instead. Generic goserelin implants are not yet available.

What should I tell my health care
provider before I take this medicine?
They need to know if you have any of these conditions (some only apply to
•menstrual bleeding problems
•osteoporosis or low bone density
•pain or difficulty passing urine
•spinal cord injury
•vaginal bleeding
•an unusual or allergic reaction to goserelin,
other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant

How should I use this medicine?
Goserelin implant is for injection subcutaneously
(injection under the skin) into the upper abdominal wall. It is only
administered under the supervision of a health care professional. You will need
one injection a month, or one injection every three months (for men only)
depending on the strength of implant used.

Contact your pediatrician or health care professional regarding the use of this
medicine in children. Special care may be needed.

What if I miss a dose?
It is important not to miss a dose. Call your prescriber or health care
professional if you are unable to keep an appointment. You should receive your
dosage within the specified time (every 4 weeks or every 3 months, depending on
the implant strength)

What drug(s) may interact with goserelin?
•herbal or dietary supplements, like black cohosh,
chasteberry, or DHEA
•female hormones, like estrogen
•male hormones, like testosterone
•some medicines for mood or mental problems

Tell your prescriber or other health care professional about all other
medicines you are taking including nonprescription medicines, nutritional
supplements, or herbal products. Also, tell your prescriber or health care
professional if you are a frequent user of drinks with caffeine or alcohol, if
you smoke or if you use illegal drugs. These may affect the way your medicine works.
Check before stopping or starting any of your medications.

What side effects may I notice
from receiving goserelin?
Side effects that you should report to your prescriber or health care
professional as soon as possible (some only apply to women):
•difficulty breathing
•chest pain
•pain in your legs or groin
•numbness in your legs
•pain, redness or irritation at the injection site
•continue to have a regular menstrual cycle
•breakthrough menstrual bleeding
•difficulty passing urine
•severe headache
•visual changes

Side effects that usually do not require medical attention (report to your
prescriber or health care professional if they continue or are bothersome)
(some only apply to women):
•breast swelling or tenderness, or decrease in breast size
•decreased sexual desire or ability (impotence)
•depression, or mood changes
•dizziness or drowsiness
•hot flashes (sudden feelings of warmth or sweating)
•loss of appetite
•muscle and joint, or bone pains
•pain during sexual intercouse
•skin problems (acne)
•swelling of the feet and legs
•vaginal dryness

What should I watch for while
taking goserelin?
Visit your prescriber or health care professional for regular checks on your
progress. During the first week your symptoms may get worse; check with your
prescriber or health care professional if they do not improve after 2 weeks.

If you are a pre-menopausal female, notify your prescriber or health care
professional if your period continues to occur. Goserelin
therapy will normally stop menstruation. However, goserelin
is not certain to work as a contraceptive, and you
should use non-hormonal methods of contraception while you receive goserelin treatment in order to avoid pregnancy. If you
think you might be pregnant, contact your health care professional. After your
treatment with goserelin is finished there may be a
delay before the return of regular menstrual periods. Check with your
prescriber or health care professional if menstruation does not restart in a
few months.

Goserelin can cause decreased bone mineral density
with prolonged use. If you smoke or frequently drink alcohol, you may increase
your risk of bone loss. A family history of osteoporosis, chronic use of drugs
for seizures (convulsions), or corticosteroids can also increase the risk of
bone loss. Talk to your prescriber regarding things you can do to help maintain
strong bones.

Where can I keep my medicine?
This does not apply. You will receive goserelin in a
hospital or clinic setting by a trained health care professional and will not
usually need to store this medication at home.


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