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Tranylcypromine Sulfate 10mg Tablet – Generic Parnate

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Antidepressants may increase the risk of suicidal thoughts
or actions in children, teenagers, and young adults. However, depression and
certain other mental problems may also increase the risk of suicide. Talk with
the patient’s doctor to be sure that the benefits of using Tranylcypromine
outweigh the risks.

Family and caregivers must closely watch patients who take
Tranylcypromine . It is important to keep in close contact with the patient’s
doctor. Tell the doctor right away if the patient has symptoms like worsened
depression, suicidal thoughts, or changes in behavior. Discuss any questions
with the patient’s doctor.

Tranylcypromine is used for:

Treating depression. It may also be used for other conditions
as determined by your doctor.

Tranylcypromine is a monoamine oxidase inhibitor (MAOI). It
works by blocking the action of the enzyme (monoamine oxidase) that breaks down
the body’s
mood-elevating chemicals (dopamine, norepinephrine, and serotonin). This
produces an increase in the activity of these mood-elevating chemicals.

Do NOT use Tranylcypromine if:

  • you are allergic to any
    ingredient in Tranylcypromine

  • you have a history of stroke, heart
    disease
    , congestive heart failure, a brain disease, headaches,
    liver disease or abnormal liver function tests, high blood pressure, or an
    adrenal gland tumor (pheochromocytoma)

  • you will be having surgery
  • you eat foods
    with a high tyramine content (eg, aged cheeses, sour cream, red wines, beer,
    bologna, pepperoni, salami, summer sausage, pickled herring, liver, meat
    prepared with tenderizers, canned figs, raisins, bananas, avocados, soy
    sauce, fava beans, yeast extracts). Ask your health care provider for a
    complete list of foods you should avoid.

  • you drink alcohol or consume
    large quantities of caffeine (coffee, tea, chocolate, or cola)

  • you are taking an amphetamine (eg,
    methylphenidate), an anesthetic, an antihistamine (eg, loratadine),
    apraclonidine, brimonidine, bupropion, buspirone, carbamazepine, certain
    herbal products (eg, ma huang), cyclobenzaprine, dextromethorphan,
    dibenzazepine, a diuretic (eg, hydrochlorothiazide), entacapone, indoramin,
    medicines for Parkinson disease (eg, levodopa), meperidine, a narcotic (eg,
    codeine), nefazodone, papaverine, a selective serotonin reuptake inhibitor (SSRI)
    (eg, fluoxetine, citalopram), a serotonin norepinephrine reuptake inhibitor
    (SNRI) (eg, duloxetine, venlafaxine), a sedative, sibutramine, a
    sympathomimetic (eg, pseudoephedrine), tolcapone, tramadol, a tricyclic
    antidepressant (eg, amitriptyline, doxepin), a triptan (eg, sumatriptan,
    zolmitriptan), or another MAOI (eg, phenelzine)

Before using Tranylcypromine :

Some medical conditions may interact with Tranylcypromine .
Tell your doctor or pharmacist if you have any medical conditions, especially if
any of the following apply to you:

  • if you are pregnant, planning to
    become pregnant, or are breast-feeding

  • if you are taking any
    prescription or nonprescription medicine, herbal preparation, or dietary
    supplement

  • if you have allergies to
    medicines, foods, or other substances

  • if you have asthma, diabetes,
    bipolar mood disorder, bronchitis, an irregular heartbeat, diabetes,
    epilepsy, an overactive thyroid, Parkinson disease, the blood disease
    porphyria, kidney problems, heart
    problems
    , or a history of suicidal thoughts or behaviors

  • if you have a history of
    substance or alcohol abuse or dependence

Some MEDICINES MAY INTERACT with Tranylcypromine . Tell your
health care provider if you are taking any other medicines, especially any of
the following:

  • Many prescription and
    nonprescription medicines (eg, used for diabetes, depression, Parkinson
    disease, headaches, pain, cold and flu, high blood pressure, seizures) may
    interact with Tranylcypromine and increase the risk of serious,
    life-threatening side effects

How to use Tranylcypromine :

Use Tranylcypromine as directed by your doctor. Check the
label on the medicine for exact dosing instructions.

  • Tranylcypromine comes with an
    extra patient information sheet called a Medication Guide. Read it
    carefully. Read it again each time you get Tranylcypromine refilled.

  • Take Tranylcypromine by mouth
    with or without food.

  • Continue to take Tranylcypromine
    even if you feel well. Do not miss any doses.

  • If you miss a dose of
    Tranylcypromine , take it as soon as possible. If it is almost time for your
    next dose, skip the missed dose and go back to your regular dosing schedule.
    Do not take 2 doses at once.

Important safety information:

  • Tranylcypromine may cause
    drowsiness or dizziness. These effects may be worse if you take it with
    alcohol or certain medicines. Use Tranylcypromine with caution. Do not drive
    or perform other possibly unsafe tasks until you know how you react to it.

  • Eating
    foods high in tyramine (eg, aged cheeses, red wines, beer, certain meats and
    sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while
    you use an MAOI may cause severe high blood pressure. This could occur for
    up to 2 weeks after you stop taking an MAOI. Do not eat foods high in
    tyramine while you take Tranylcypromine . Ask your health care provider for
    a complete list of foods you should avoid. Seek medical attention at once if
    symptoms of severe high blood pressure occur. These may include severe
    headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting,
    sweating, enlarged pupils, or sensitivity to light.

  • Avoid large amounts of food or
    drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).

  • Do not drink alcohol or use
    medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while
    you are using Tranylcypromine ; it may add to their effects. Ask your
    pharmacist if you have questions about which medicines may cause drowsiness.

  • Tranylcypromine may cause
    dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or
    fever may increase these effects. To prevent them, sit up or stand slowly,
    especially in the morning.
    Sit or lie down at the first sign of any of these effects.

  • Children and teenagers who take
    Tranylcypromine may be at increased risk for suicidal thoughts or actions.
    Adults may also be affected. The risk may be greater in patients who have
    had suicidal thoughts or actions in the past. The risk may also be greater
    in patients who have had bipolar (manic-depressive) illness, or if their
    family members have had it. Watch patients who take Tranylcypromine closely.
    Contact the doctor at once if new, worsened, or sudden symptoms such as
    depressed mood; anxious, restless, or irritable behavior; panic attacks; or
    any unusual change in mood or behavior occur. Contact the doctor right away
    if any signs of suicidal thoughts or actions occur.

  • Tranylcypromine may cause you to
    become sunburned more easily. Avoid the sun, sunlamps, or tanning booths
    until you know how you react to Tranylcypromine . Use a sunscreen or wear
    protective clothing if you must be outside for more than a short time.

  • Tell your doctor or dentist that
    you take Tranylcypromine before you receive any medical or dental
    care
    , emergency care, or surgery.

  • Before you begin taking any new
    medicine, either prescription or nonprescription, check with your doctor or
    pharmacist.

  • Diabetes patients –
    Tranylcypromine may affect your blood sugar. Check blood sugar levels
    closely. Ask your doctor before you change the dose of your diabetes
    medicine.

  • Lab tests, including blood
    pressure monitoring, may be performed while you use Tranylcypromine . These
    tests may be used to monitor your condition or check for side effects. Be
    sure to keep all doctor and lab appointments.

  • Use Tranylcypromine with caution
    in the ELDERLY; they may be more sensitive to its effects, especially
    difficulty sleeping and enlarged prostate.

  • Tranylcypromine should be used
    with extreme caution in CHILDREN; safety and effectiveness in children have
    not been confirmed. CHILDREN taking Tranylcypromine may be at increased risk
    of suicidal thoughts and behaviors.

  • PREGNANCY and BREAST-FEEDING: If
    you become pregnant, contact your doctor. You will need to discuss the
    benefits and risks of using Tranylcypromine while you are pregnant.
    Tranylcypromine is found in breast milk. Do not breast-feed while taking
    Tranylcypromine .

If you stop taking Tranylcypromine suddenly, you may have
WITHDRAWAL symptoms. These may include restlessness, anxiety, depression,
confusion, hallucinations, headache, weakness, and diarrhea.

Possible side effects of Tranylcypromine :

All medicines may cause side effects, but many people have
no, or minor, side effects. Check with your doctor if any
of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation;
diarrhea; drowsiness; dry mouth; stomach pain; tremors; upset stomach;
weakness.

Seek medical attention right away if any of these SEVERE
side effects occur:

Severe allergic reactions (rash; hives; difficulty
breathing; tightness in the chest; swelling of the mouth, face, lips, or
tongue); agitation or anxiety; bizarre behavior; blurred vision; chest
pain
; difficulty sleeping; dilated pupils; dizziness; fainting;
fast, slow, or irregular heartbeat; feelings of irritability and hostility;
fever; headache; impulsive behavior or other unusual changes in behavior;
nausea; panic attacks; pounding in the chest; sensitivity to light; severe
nervousness or anxiety; severe restlessness; sleeplessness; sore or stiff
neck; sweating (sometimes with fever or cold, clammy skin); thoughts of
suicide; vomiting; worsening feelings of depression.

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