Isavuconazonium injection is used to treat severe fungi infections such invasive mucormycosis and invasive aspergillosis, which start in the lungs and spread through the bloodstream to other organs (a fungal infection that usually begins in the sinuses, brain, or lungs). Isavuconazonium injection belongs to the group of drugs known as azole antifungals. It functions by inhibiting the development of infection-causing fungus.

The powder form of isavuconazonium injection is combined with fluids before being administered intravenously (into a vein). For the first six doses, it is typically administered over at least an hour every eight hours, and subsequently only once per day. Your general health, the sort of infection you have, and how well you respond to the medication will all influence how long it takes for you to complete your treatment. You can administer isavuconazonium injection at home or receive it at a hospital. When you receive isavuconazonium injection at home, your doctor will demonstrate how to administer the drug. Make sure you comprehend these instructions, and if you have any issues, consult your healthcare professional.

When receiving an injection of isavuconazonium, a response could occur. Upon receiving an isavuconazonium injection, report any of the following symptoms to your doctor right away: dizziness, trouble breathing, chills, altered sense of touch, or numbness or tingling of the skin. Until your symptoms are better, your doctor may decide to discontinue the infusion.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving isavuconazonium injection,

• Isavuconazonium, fluconazole (Diflucan), itraconazole (Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), voriconazole (Vfend), any other drugs, or any of the constituents in isavuconazonium injection should not be taken if you have any of these allergies. Get a list of the components from your pharmacist.
• Inform your physician if you are taking any of the following medications: phenobarbital, rifampin (Rifadin, Rifamate), carbamazepine (Carbatrol, Tegretol), ketoconazole (Nizoral), ritonavir (Norvir, in Kaletra), or St. John’s wort. If you take one or more of these drugs, your doctor will likely advise you not to use isavuconazonium injection.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: midazolam, mycophenolate mofetil (CellCept), sirolimus (Rapamune), bupropion (Aplenzin, Forfivo XL, Wellbutrin, in Contrave), cyclosporine (Gengraf, Neoral, Sandimmune), atorvastatin (Lipitor, in Caduet), sirolimus (Aplenzin, Forfivo XL, Wellbutrin, in Contra (Astagraf, Prograf). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of the medications you are taking, even any not on this list, since many other drugs may also interact with isavuconazonium.
• Inform your physician if you or any family members currently or in the past have short QT syndrome (condition that increases the risk of irregular heartbeat, dizziness, fainting, or sudden death). Most likely, your doctor will advise against getting an injection of isavuconazonium.
• Inform your physician if you now experience or have ever experienced an irregular heartbeat, low potassium levels, other cardiac issues, or liver issues.
• If you are pregnant or plan to become pregnant, let your doctor know. Throughout your isavuconazonium injectable treatment and for 28 days following your last dose, you should take birth control to avoid becoming pregnant. Discuss the various birth control methods that will work for you with your doctor. Call your doctor if you conceive while having isavuconazonium injection.The foetus could suffer from isavuconazonium.
• If you are breastfeeding, let your doctor know.

If you plan to consume grapefruit or grapefruit juice while taking this medicine, consult your doctor.

The injection of isavuconazonium might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Diarrhea
• Constipation
• Headache
• Back ache
• Cough
• Having trouble falling or staying asleep
• Anxiety
• Agitation
• Confusion
• Reduction in appetite

Certain adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

• Hives, face, tongue, or throat swelling, chest pain, a rapid heartbeat, dizziness or fainting, sweating, or trouble breathing or swallowing
• Blistered or flaking skin
• Symptoms of the flu such as yellowing of the skin or eyes, upper right stomach ache, nausea, vomiting, itching, and extreme exhaustion
• Unsteady heartbeat
• Swelling of the arms, legs, feet, or hands

Further negative consequences of isavuconazonium injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

• Headache
• Dizziness
• Hands or feet tingling, burning, or pain
• Drowsiness
• Having trouble focusing
• Alterations in taste
• Mouth ache
• Tingling in the mouth
• Diarrhea
• Vomiting
• Abrupt facial, upper chest, or neck redness
• Anxiety
• Restlessness
• Rapid or hammering heartbeat
• Light sensitivity of the eyes
• Joints hurt

Keep all of your appointments with your physician and the lab. To determine how well your body has responded to the injection of isavuconazonium, your doctor could conduct a few lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.