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Clozaril (Clozapine) – 25mg Generic Tablet

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This is a summary of the most important information about Clozaril. For details, talk to your healthcare professional.

What is Clozaril?

Clozaril is a prescription medicine used to treat people with severe forms of schizophrenia that have not responded to or cannot take other treatments.
Clozaril is also used to lower the risk of suicidal behavior in people with schizophrenia or schizoaffective disorder.
Clozaril is not approved for use in children.

Who Should Not Take Clozaril?

You should not take Clozaril if:

  • You are taking other medicines that can cause the same serious bone marrow side effects as
  • You can ask your healthcare professional for a complete list of these medications.

What are The Risks?

The following are the risks and potential side effects of
Clozaril therapy. However, this list is not complete.

  • Increased chance of death in elderly persons.
    Elderly patients treated with atypical antipsychotics, such as
    Clozaril, for dementia had a higher chance for death than patients
    who did not take the medicine. Clozaril is not approved for
  • Agranulocytosis, a potentially life-threatening
    reaction where the body’s bone marrow does not produce enough
    white blood cells. Because of this risk, your healthcare
    professional must monitor your blood while you are taking Clozaril.
  • Seizures. The risk of seizure is increased in
    people who have a history of seizures or other predisposing
    factors. Because of this risk you should not engage in any
    activity where you may suddenly lose consciousness, such as
    operating complex machinery, driving, swimming, climbing, etc.
  • Heart problems. Clozaril can cause a condition
    called myocarditis, or swelling of the heart muscle. Some of the
    warning signs of myocarditis are tiredness, shortness of breath,
    rapid breathing, fever, chest pain, and irregular heart beat. If
    these happen, call your healthcare professional right away.
  • Lowering of blood pressure when you stand up.
    This may also lead to fainting. In rare instances, this has been
    associated with lung and/or heart collapse.

Clozaril and other antipsychotic medications can cause serious problems such as:

  • A life-threatening nervous system problem called neuroleptic malignant syndrome (NMS). NMS can cause a high fever, stiff muscles, sweating, a fast or irregular heart beat, change in blood pressure, and confusion. NMS can affect your kidneys. NMS is a medical emergency. Call your healthcare professional right away if you experience these symptoms.
  • A movement problem called tardive dyskinesia (TD). Call your healthcare professional right away if you get muscle movements that cannot be stopped.
  • High blood sugar and diabetes. Patients with diabetes or who have a higher chance for diabetes should have their blood sugar checked often.
  • Other serious side effects may include fever, blood clots in the lung, increased blood sugar, and liver disease.
  • The most common side effects include drowsiness, increased salivation, rapid heart beat, dizziness, constipation, headache, shaking, and lightheadedness.

What Should I Tell My Healthcare Professional?

Before you start using Clozaril, tell your healthcare professional if you:

  • have or had heart or lung problems
  • have or had seizures
  • have or had blood clots
  • have or had diabetes or increased blood sugar
  • have or had liver disease
  • have or had glaucoma
  • have or had stomach problems
  • have or had prostate enlargement
  • are trying to become pregnant, are already pregnant, or are breast-feeding.
  • drink alcohol
  • smoke

Are There Any Interactions With Drugs or Foods?

Because certain other medications can interact with Clozaril, review all medications that you are taking with your health care professional, including those that you take without a prescription. You should not take
Clozaril if you are taking other medicines that can cause the same serious bone marrow side effects as

Your healthcare professional may have to adjust your dose or watch you more closely if you take the following medications:

  • certain medicines used to treat anxiety, called benzodiazepines
  • certain medicines used to clear thoughts, called psychotropic drugs
  • epinephrine
  • phenytoin
  • rifampin
  • cimetidine
  • erythromycin
  • carbamazepine
  • fluvoxamine
  • paroxetine

Avoid drinking alcohol while taking Clozaril.

Is There Anything Else I Need to Know?

  • Dizziness, and sometimes fainting, caused by a drop in blood pressure may happen with
    Clozaril, especially when you first start taking this medicine or when the dose is increased.
  • Clozaril may impair judgment, thinking, or motor skills. You should be careful in operating machinery, including automobiles, until you know how
    Clozaril affects you.
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