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Ceftazidime and Avibactam Injection

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Why is this medication prescribed?

To treat abdominal (stomach area) infections, ceftazidime and avibactam injection is used with metronidazole (Flagyl). Moreover, it is used to treat renal and urinary tract infections as well as pneumonia that developed in patients who were hospitalised or on ventilators. Ceftazidime belongs to the group of drugs known as cephalosporin antibiotics. It eliminates bacteria to operate. The drug avibactam belongs to the group of drugs known as beta-lactamase inhibitors. It functions by stopping bacteria from metabolising ceftazidime.

Colds, the flu, and other viral diseases cannot be treated with antibiotics such ceftazidime and avibactam. Antibiotic overuse raises the likelihood that you’ll get an infection later on that is resistant to antibiotic therapy.

How should this medicine be used?

The combination of ceftazidime and avibactam injection comes as a powder to be added to fluid and injected intravenously (into a vein). It is usually infused (injected slowly) intravenously over a period of 2 hours every 8 hours. The length of your treatment depends on your general health, the type of infection you have and how well you respond to the medication. Your doctor will tell you how long to use ceftazidime and avibactam injection. You may receive ceftazidime and avibactam injection in a hospital or you may administer the medication at home. If you will be receiving ceftazidime and avibactam injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Be sure you comprehend these instructions, and if you have any concerns, consult your healthcare practitioner.

After the first several days of treatment with ceftazidime and avibactam injection, you should start to feel better. Inform your doctor if your symptoms do not get better or worsen. After finishing the ceftazidime and avibactam injection, let your doctor know if you continue to experience signs of infection.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using ceftazidime and avibactam injection,

  • Inform your doctor and pharmacist if you have any allergies to the following medications: ceftazidime and avibactam injection, carbapenem antibiotics such as doripenem (Doribax), imipenem and cilastatin (Primaxin), or meropenem (Merrem); cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin (Ancef, Kefzol), cef (Maxipime), cefixime (Suprax), cefotaxime (Claforan), cefoxitin, cefpodoxime, cefprozil, ceftazidime (Fortaz, Tazicef, in Avycaz), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Ceftin, Zinacef), and cephalexin (Keflex); penicillin; any other medications, or any of the ingredients in ceftazidime and avibactam injection. Get an ingredient list from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: probenecid (Probalan, in Col-Probenecid) (Probalan, in Col-Probenecid). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have renal illness now or ever have, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking ceftazidime and avibactam injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

There may be negative effects from using ceftazidime and avibactam injection. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Vomiting
  • Nausea
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Dizziness
  • Headache

Some adverse effects may be severe. Call your doctor right away or seek emergency medical attention if you have any of these symptoms:

  • Hives, trouble breathing or swallowing, rash, itching, or a rash
  • Severe diarrhoea with faeces that are red or watery (up to 2 months after your treatment)
  • Seizures
  • Confusion
  • Quick, uncontrollable muscle twitching or jerking
  • Hand trembling
  • Seeing or hearing things or voices that are not there
  • Coma (loss of consciousness for a period of time)

Such negative effects could result from using ceftazidime and avibactam injection. If you have any strange side effects while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how your body is responding to the ceftazidime and avibactam injection, your doctor may request specific lab tests.

Ceftazidime with avibactam injection can skew the findings of some urine glucose tests if you have diabetes. Discuss with your doctor which glucose tests you can use while receiving ceftazidime and avibactam injectable treatment.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Avycaz®
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