Spironolactone is used for:
Treating swelling and fluid retention in patients with congestive heart failure, liver cirrhosis, or kidney problems (nephrotic syndrome). It is also used for treatment of high blood pressure. Spironolactone may also be used to treat or prevent low blood potassium. It may also be used to treat excess secretion of the hormone aldosterone by the adrenal gland.
Spironolactone is a potassium-sparing diuretic. It works by blocking the hormone aldosterone, causing the kidney to eliminate excess water, save potassium, and lower blood pressure
Do NOT use Spironolactone if:
- you are allergic to any ingredient in Spironolactone
- you are unable to urinate, have severe kidney problems, or have high blood potassium levels
- you are taking a potassium supplement, another potassium-sparing diuretic (eg, amiloride, triamterene), or another aldosterone-blocker (eg, eplerenone)
Some MEDICINES MAY INTERACT with Spironolactone . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Adrenocorticotropic hormone (corticotropin) (ACTH) or corticosteroids (eg, prednisone) or because low blood electrolyte levels may occur
- Barbiturates (eg, phenobarbital) or narcotics (eg, morphine) because dizziness upon standing may occur
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin II receptor antagonists (eg, valsartan), cyclosporine, macrolide immunosuppressives (eg, tacrolimus), other aldosterone-blockers (eg, eplerenone), other potassium sparing diuretics (eg, amiloride, triamterene), or potassium supplements because high blood potassium levels may occur (eg, listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, potentially life-threatening slow or irregular heartbeat)
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Spironolactone 's effectiveness and increase the risk of kidney problems and high blood potassium
- Digoxin, digitoxin, lithium, nondepolarizing muscle relaxants (eg, tubocurarine), or quinidine because the risk of their side effects and toxicity may be increased by Spironolactone
- Pressor amines (eg, norepinephrine) because their effectiveness may be decreased by Spironolactone
How to use Spironolactone :
Use Spironolactone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Spironolactone by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Spironolactone may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
- If you miss a dose of Spironolactone , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, restart the medication and advise your doctor or pharmacist at your next appointment
Possible side effects of Spironolactone :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; drowsiness; headache; nausea; stomach cramping; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; change in the amount of urine produced; confusion; dark urine; decreased sexual ability; enlarged breasts in men; irregular or missed menstrual periods; pale stools; severe or persistent stomach pain; symptoms of abnormal fluid or electrolyte levels (eg, fast, slow, or irregular heartbeat; increased thirst; muscle weakness; severe or persistent dry mouth, nausea, or vomiting; severe or persistent dizziness or drowsiness; unusual fatigue or sluggishness; tingling sensation); yellowing of the skin or eyes.