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Bisoprolol/HCTZ 10-6.25mg Tablet - Generic Ziac
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30 tablets $9.99  
90 tablets $28.47  
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Bisoprolol/Hydrochlorothiazide is used for:

Treating high blood pressure.

Bisoprolol/Hydrochlorothiazide is a beta-blocker and diuretic combination. Bisoprolol/Hydrochlorothiazide works by slowing down the heartbeat, helping the heart beat more regularly, and reducing the amount of work the heart has to do. Bisoprolol/Hydrochlorothiazide also increases the elimination of excess fluid, which helps to decrease blood pressure.

Do NOT use Bisoprolol/Hydrochlorothiazide if:

  • you are allergic to any ingredient in Bisoprolol/Hydrochlorothiazide or to a sulfonamide medicine (eg, sulfamethoxazole, probenecid, glyburide)
  • you have uncontrolled heart failure, heart block, a very slow heart rate, or low blood pressure
  • you are unable to urinate
  • you are taking another beta-blocker (eg, propranolol), dofetilide, or mibefradil

Before using Bisoprolol/Hydrochlorothiazide :

Some medical conditions may interact with Bisoprolol/Hydrochlorothiazide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have asthma, bronchitis, lung disease (eg, chronic obstructive pulmonary disease [COPD]), diabetes, gout, an overactive thyroid, low blood levels of potassium or sodium, heart problems (eg, congestive heart failure), blood vessel problems, pheochromocytoma, lupus, liver disease, or kidney problems
  • if you are having surgery or receiving anesthesia

Some MEDICINES MAY INTERACT with Bisoprolol/Hydrochlorothiazide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, disopyramide), calcium channel blockers (eg, verapamil, diltiazem), or cimetidine because side effects, such as slow or irregular heart beat or low blood pressure, may occur
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), barbiturates (eg, phenobarbital), clonidine, diazoxide, flecainide, mefloquine, mibefradil, narcotics (eg, codeine), or nifedipine because the actions and side effects of Bisoprolol/Hydrochlorothiazide and these medicines may be increased
  • Other beta-blockers (eg, propranolol), clonidine, corticosteroids (eg, prednisone), guanethidine, or reserpine because they may increase the risk of Bisoprolol/Hydrochlorothiazide 's side effects
  • Anionic exchange resins (eg, cholestyramine, colestipol) and nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because they may decrease Bisoprolol/Hydrochlorothiazide 's effectiveness
  • Allopurinol, amantadine, digitalis (eg, digoxin), dofetilide, insulin, ketanserin, lithium, or medicines for diabetes (eg, glyburide) because their actions and the risk of their side effects may be increased

How to use Bisoprolol/Hydrochlorothiazide :

Use Bisoprolol/Hydrochlorothiazide as directed by your doctor. Check the label on Bisoprolol/Hydrochlorothiazide exact dosing instructions.

  • Take Bisoprolol/Hydrochlorothiazide by mouth with or without food.
  • Bisoprolol/Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Bisoprolol/Hydrochlorothiazide , take the missed dose if you remember the same day. Skip the missed dose if you do not remember the same day. Do not take 2 doses at once.

Important safety information:

  • Bisoprolol/Hydrochlorothiazide may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Bisoprolol/Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Bisoprolol/Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • If you stop taking Bisoprolol/Hydrochlorothiazide suddenly, you may have WITHDRAWAL symptoms. These may include sharp chest pain, fast or irregular heartbeat, and heart attack. When stopping treatment with Bisoprolol/Hydrochlorothiazide , your doctor will need to slowly decrease your dose over a period of 1 to 2 weeks and will watch you closely for side effects, especially if you have certain kinds of heart disease. If chest pain becomes more severe or a heart problem develops, Bisoprolol/Hydrochlorothiazide should be restarted at once, at least temporarily, and other measures to help unstable chest pain should be taken. Because heart artery disease is common and you may not know you have it, it may be safer not to stop Bisoprolol/Hydrochlorothiazide quickly even if you are only being treated for high blood pressure.
  • Bisoprolol/Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Bisoprolol/Hydrochlorothiazide . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Bisoprolol/Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Diabetes patients - Bisoprolol/Hydrochlorothiazide may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood pressure, heart rate, and blood electrolytes, may be performed while you use Bisoprolol/Hydrochlorothiazide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Bisoprolol/Hydrochlorothiazide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Bisoprolol/Hydrochlorothiazide can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bisoprolol/Hydrochlorothiazide while you are pregnant. Bisoprolol/Hydrochlorothiazide is found in breast milk. Do not breast-feed while taking Bisoprolol/Hydrochlorothiazide .

Possible side effects of Bisoprolol/Hydrochlorothiazide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; dizziness; headache; lightheadedness; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; chills, fever, or sore throat; fainting; mood or mental changes (eg, anxiety, decreased concentration, decreased memory, depression, hallucinations, restlessness); muscle pain or weakness; red, swollen, blistered, or peeling skin; ringing in the ears or decreased hearing; severe dizziness; slow or irregular heartbeat; swelling of the ankles or feet; unusual bruising or bleeding; unusual thirst or fatigue; vision changes or blurred vision; yellowing of the skin or eyes.

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