Chemical Name: COLCHICINE (KOL-chi-seen) and PROBENECID (proe-BEN-e-sid)
Probenecid/Colchicine is a combination antigout and uric acid lowering agent used to treat gout and gouty arthritis. Probenecid/Colchicine may be used also be used to treat other conditions as determined by your doctor.
Some medicines or medical conditions may interact with Probenecid/Colchicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE Probenecid/Colchicine if you are also taking aspirin or other salicylates on a regular basis. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking fluvastatin, ganciclovir, macrolide antibiotics (such as clarithromycin or erythromycin), methotrexate, theophylline medicines (such as dyphylline), or zidovudine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including ulcers, kidney problems, allergies, pregnancy, or breast-feeding. USE OF Probenecid/Colchicine IS NOT RECOMMENDED if you have a history of blood problems or a history of uric acid kidney stones. Use of Probenecid/Colchicine in children under 2 years of age is not recommended. Discuss with your doctor the risks and benefits of giving Probenecid/Colchicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Follow the directions for using Probenecid/Colchicine provided by your doctor. Probenecid/Colchicine MAY BE TAKEN WITH FOOD if it upsets your stomach. DRINKING EXTRA FLUIDS while you are taking Probenecid/Colchicine is recommended. Check with your doctor or nurse for instructions. STORE Probenecid/Colchicine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly-closed container, away from heat and light. IF YOU MISS A DOSE OF Probenecid/Colchicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
DO NOT TAKE Probenecid/Colchicine if you have had an allergic reaction to it or are allergic to any ingredient in this product. IF YOU EXPERIENCE difficulty breathing; tightness of chest; swelling of eyelids, face, or lips; or if you develop a rash or hives, tell your doctor immediately. Do not take any more of Probenecid/Colchicine unless your doctor tells you to do so. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using Probenecid/Colchicine. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor. This includes aspirin or non-steroidal anti-inflammatory products (such as ibuprofen, ketoprofen, or naproxen). FOR WOMEN: Probenecid/Colchicine HAS BEEN SHOWN TO CAUSE HARM to the human fetus. IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using Probenecid/Colchicine during pregnancy. Probenecid/Colchicine IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using Probenecid/Colchicine, check with your doctor or pharmacist to discuss the risks to your baby. IF YOU HAVE DIABETES MELLITUS, Probenecid/Colchicine may cause false test results with some urine glucose tests. Check with your doctor before adjusting the dose of your diabetes medicine or changing your diet.
Possible side effects
SIDE EFFECTS that may occur while taking Probenecid/Colchicine include headache, dizziness, nausea, or vomiting. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience loss of appetite, sore gums, sore throat, fever, severe diarrhea, severe vomiting, stomach pain, unusual tiredness or weakness, numbness or tingling, unusual bleeding or bruising, or changes in urine production. An allergic reaction to Probenecid/Colchicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
If you take too much
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea; vomiting; diarrhea; stomach pain; burning pain in throat, stomach, and skin; blood in urine; and muscle weakness.
IT MAY TAKE SEVERAL MONTHS for Probenecid/Colchicine to work. Do not stop using Probenecid/Colchicine without checking with your doctor. DO NOT SHARE Probenecid/Colchicine with others for whom it was not prescribed. DO NOT USE Probenecid/Colchicine for other health conditions. KEEP Probenecid/Colchicine out of the reach of children. IF USING Probenecid/Colchicine FOR AN EXTENDED PERIOD OF TIME, be sure to obtain refills before your supply runs out.