Olanzapine is an antipsychotic. Olanzapine may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Olanzapine is not approved to treat mental problems caused by dementia.
Olanzapine is used for: Treating schizophrenia or bipolar disorder. Olanzapine is also used along with another medicine (fluoxetine) to treat certain types of depression. Olanzapine may also be used for other conditions as determined by your doctor. Olanzapine is an atypical antipsychotic. Exactly how it works is not known. Olanzapine is thought to affect certain substances in the brain. Do NOT use Olanzapine if:
- you are allergic to any ingredient in Olanzapine
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of seizures, heart problems (eg, heart failure; fast, slow, or irregular heartbeat), abnormal electrocardiogram (ECG), heart attack, stroke or mini-stroke, blood vessel problems, high blood cholesterol levels, high or low blood pressure, or low white blood cell levels
- if you have a history of liver problems, stomach or bowel problems (eg, decreased muscle movement), enlarged prostate, narrow-angle glaucoma, neuroleptic malignant syndrome (NMS), aspiration pneumonia, or suicidal thoughts or attempts
- if you have Alzheimer disease, bowel blockage, dementia, or trouble swallowing
- if you have diabetes or are very overweight, or if a family member has had diabetes
- if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary), or if you are at risk for breast cancer
- if you are dehydrated, drink alcohol, smoke, or you will be exposed to high temperatures
- Alpha blockers (eg, doxazosin), diazepam, or medicine for high blood pressure because the risk of low blood pressure and fainting may be increased
- Anticholinergics (eg, scopolamine), benzodiazepines (eg, lorazepam), or fluvoxamine because they may increase the risk of Olanzapine 's side effects
- Carbamazepine, HIV protease inhibitors (eg, ritonavir), omeprazole, or rifampin because they may decrease Olanzapine 's effectiveness
- Dopamine receptor agonists (eg, pramipexole) or levodopa because their effectiveness may be decreased by Olanzapine
- Olanzapine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Olanzapine refilled.
- Take Olanzapine by mouth with or without food.
- Drinking extra fluids while you are taking Olanzapine is recommended. Check with your doctor for instructions.
- Continue to take Olanzapine even if you feel well. Do not miss any doses.
- If you miss a dose of Olanzapine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
- Olanzapine may cause dizziness, drowsiness, or decreased vision. These effects may be worse if you take it with alcohol or certain medicines. Use Olanzapine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol while you are taking Olanzapine .
- Talk with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Olanzapine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Olanzapine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do not suddenly stop taking Olanzapine without checking with your doctor.
- Do not become overheated in hot weather or while you are being active; heatstroke may occur.
- Olanzapine may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Olanzapine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- NMS is a possibly fatal syndrome that can be caused by Olanzapine . Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
- Some patients who take Olanzapine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Olanzapine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Olanzapine .
- Lab tests, including fasting blood glucose, cholesterol, complete blood cell counts, and liver function, may be performed while you take Olanzapine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Olanzapine with caution in the ELDERLY; they may be more sensitive to its effects, especially uncontrolled muscle movements.
- Caution is advised when using Olanzapine in CHILDREN; they may be more sensitive to its effects, especially drowsiness, increased cholesterol and lipid levels, increased levels of prolactin (a hormone), and weight gain. Children may need regular weight checks while they take Olanzapine .
- Olanzapine should be used with extreme caution in CHILDREN younger than 13 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Olanzapine while you are pregnant. Olanzapine is found in breast milk. Do not breast-feed while taking Olanzapine .